Drug fever attributable to Calcium Dobesilate.

Many drugs may cause fever through different mechanisms, the most frequent being hypersensitivity. We are reporting on two cases of drug fever attributable to Calcium Dobesilate, a drug used for treating chronic venous insufficiency and other vascular disturbances. The diagnosis was made by oral challenge with the drug. It reproduced the clinical picture referred to in the anamnesis, including hyperthermia. In patient 2 the challenge proved to be useful though she was being treated with oral corticosteroids for systemic lupus erythematosus (SLE). Cutaneous tests (PRICK and patch tests) were negative with the suspected drug; however we think that an immunological mechanism could be responsible for the reactions.