A long-period radio transient active for three decades.

Several long-period radio transients have recently been discovered, with strongly polarized coherent radio pulses appearing on timescales between tens to thousands of seconds1,2. In some cases, the radio pulses have been interpreted as coming from rotating neutron stars with extremely strong magnetic fields, known as magnetars; the origin of other, occasionally periodic and less-well-sampled radio transients is still debated3. Coherent periodic radio emission is usually explained by rotating dipolar magnetic fields and pair-production mechanisms, but such models do not easily predict radio emission from such slowly rotating neutron stars and maintain it for extended times. On the other hand, highly magnetic isolated white dwarfs would be expected to have long spin periodicities, but periodic coherent radio emission has not yet been directly detected from these sources. Here we report observations of a long-period (21 min) radio transient, which we have labelled GPM J1839-10. The pulses vary in brightness by two orders of magnitude, last between 30 and 300 s and have quasiperiodic substructure. The observations prompted a search of radio archives and we found that the source has been repeating since at least 1988. The archival data enabled constraint of the period derivative to <3.6 × 10-13 s s-1, which is at the very limit of any classical theoretical model that predicts dipolar radio emission from an isolated neutron star.

A radio transient with unusually slow periodic emission.

The high-frequency radio sky is bursting with synchrotron transients from massive stellar explosions and accretion events, but the low-frequency radio sky has, so far, been quiet beyond the Galactic pulsar population and the long-term scintillation of active galactic nuclei. The low-frequency band, however, is sensitive to exotic coherent and polarized radio-emission processes, such as electron-cyclotron maser emission from flaring M dwarfs1, stellar magnetospheric plasma interactions with exoplanets2 and a population of steep-spectrum pulsars3, making Galactic-plane searches a prospect for blind-transient discovery. Here we report an analysis of archival low-frequency radio data that reveals a periodic, low-frequency radio transient. We find that the source pulses every 18.18 min, an unusual periodicity that has, to our knowledge, not been observed previously. The emission is highly linearly polarized, bright, persists for 30-60 s on each occurrence and is visible across a broad frequency range. At times, the pulses comprise short-duration (<0.5 s) bursts; at others, a smoother profile is observed. These profiles evolve on timescales of hours. By measuring the dispersion of the radio pulses with respect to frequency, we have localized the source to within our own Galaxy and suggest that it could be an ultra-long-period magnetar.

Entirely reflective slit spatial filter for high-energy laser systems.

An entirely reflective slit spatial filter is proposed to provide spatial filtering, gain isolation, and ASE mitigation for high-energy laser systems. The traditional circular pinhole is replaced by two orthogonal slits, which lowers the intensity at the spatial filter plane by up to two orders of magnitude, and by using reflective optics we reduce spatial dispersion and eliminate B-integral effects. A ray trace model of the spatial filter shows excellent transmitted wavefront, but also indicates aberrations at the foci from using cylindrical optics at 45°. It is expected that the use of off-axis parabolic mirrors would mitigate this issue but comes at the cost of more complicated, expensive optics and more complex alignment. We created a numerical model based on Fourier optics to explain this effect and guide design requirements to mitigate it. High-quality imaging and filtering capabilities are demonstrated experimentally.

Markov-Airy description of optical scattering, waveguides, and resonators.

Representing the reflection and transmission of light by multilayer dielectric structures in terms of Markov chains provides an intuitive, precise, and computationally efficient framework for calculating the dispersive properties (group delay, group delay dispersion, and higher order phase derivatives) of ultrafast laser mirrors and other broadband optical components. The theoretical basis for the Markov-Airy formalism is described, and its ability to precisely determine the dispersive characteristics of multilayer dielectric structures is demonstrated here. Exact expressions for the three lowest order phase derivatives for a dielectric mirror and waveguide are derived, and Markov-Airy-based numerical simulations of specific mirror designs are compared with results obtained with the conventional transition matrix formalism.

Interruption of electronically excited Xe dimer formation by the photoassociation of Xe(6s[3/2]2)-Xe(5p(6) (1)S0) thermal collision pairs.

The diatomic collisional intermediate responsible for the formation of an electronically excited molecule by teratomic recombination has been observed in both the spectral and temporal domains by laser spectroscopy. We report experiments demonstrating thermal Xe(6s[3/2]2)-Xe(5p(6) (1)S0) atomic collision pairs to be the immediate precursor to the formation of Xe2 (∗)(a(3)Σu (+),A(1)Σu (+)) by the three body process: Xe(∗)(6s) + 2Xe ⟶ Xe2 (∗) + Xe, where the asterisk denotes an excited electronic state. Photoassociating Xe(6s)-Xe atomic pairs by free ⟵ free transitions of the collision complex interrupts the production of the electronically excited Xe dimer, thereby suppressing Xe2 spontaneous emission in the vacuum ultraviolet (VUV, λ ∼ 172 nm, A(1)Σu (+)→X(1)Σg (+)). Intercepting Xe(6s)-Xe pairs before the complex is stabilized by the arrival of the third atom in the teratomic collision process selectively depletes the pair population in a specific Franck-Condon region determined by the probe laser wavelength (λ). Measurements of the variation of VUV emission suppression with λ provide a spectral signature of the [Xe(6s[3/2]2) - Xe((1)S0)](∗) complex and map the probe laser wavelength onto the thermal energy (ϵ″) of the incoming collision pairs.

GaLactic and Extragalactic All-sky Murchison Widefield Array survey eXtended (GLEAM-X) I: Survey Description and Initial Data Release.

We describe a new low-frequency wideband radio survey of the southern sky. Observations covering 72-231MHz and Declinations south of +30° have been performed with the Murchison Widefield Array "extended" Phase I I configuration over 2018-2020 and will be processed to form data products including continuum and polarisation images and mosaics, multi-frequency catalogues, transient search data, and ionospheric measurements. From a pilot field described in this work, we publish an initial data release covering 1,447 deg2 over 4 h≤ RA≤ 13 h, -32.7° ≤ Dec ≤ -20.7°. We process twenty frequency bands sampling 72-231 MHz, with a resolution of 2'-45″, and produce a wideband source-finding image across 170-231MHz with a root-mean-square noise of 1.27 ± 0.15 mJy beam-1. Source-finding yields 79,124 components, of which 71,320 are fitted spectrally. The catalogue has a completeness of 98% at ~ 50 mJy, and a reliability of 98.2% at 5σ rising to 99.7% at 7σ. A catalogue is available from Vizier; images are made available on the GLEAM-X VO server and SkyView. This is the first in a series of data releases from the GLEAM-X survey.

Xe2 gerade Rydberg states observed in the afterglow of a microplasma by laser spectroscopy of a(3)Σ(+)(u)(1(u), O(-)(u)) absorption in the green (545-555 nm) and near-infrared (675-800 nm).

Bound←bound transitions of the Xe dimer at small internuclear separation (R < 4.0 Å) have been observed in the 545-555 nm and 675-800 nm spectral regions by laser spectroscopy in the afterglow of a pulsed Xe microplasma with a volume of ∼160 nl. Transient suppression of Xe2 A(1)Σ(+)(u)(O(+)(u)) --> X(1)Σ(+)(g)(O(+)(g)) emission in the vacuum ultraviolet (∼172 nm), induced by laser excitation of Ω(g) ← a(3)Σ(+)(u)(1(u), O(-)(u)) [Rydberg←Rydberg] transitions of the molecule, has confirmed the existence of structure between 720 and 770 nm (reported by Killeen and Eden [J. Chem. Phys. 84, 6048 (1986)]) but also reveals red-degraded vibrational bands extending to wavelengths beyond 800 nm. Spectral simulations based on calculations of Franck-Condon factors for assumed Ω(g) ← a(3)Σ(+)(u) transitions involving Ω = 0(±),1 gerade Rydberg states suggest that the upper level primarily responsible for the observed spectrum is an Ω = 1 state correlated, in the separated atom limit, with Xe(5p(6) (1)S0) + Xe(5p(5) 6p) and built on a predominantly A(2)Π3/2g molecular ion core. Specifically, the spectroscopic constants for the upper state of the 1(g) ← 1(u), O(±)(u) absorptive transitions are determined to be Te = 13,000 ± 150 cm(-1), ω'(e) = 120 ± 10 cm(-1), ω'(e)x'(e) = 1.1 ± 0.4 cm(-1), De = 3300 ± 300 cm(-1), and ΔR(e) = R'(e) = R''(e) = 0.3 ± 0.1 Å which are in general agreement with the theoretical predictions of the pseudopotential hole-particle formalism, developed by Jonin and Spiegelmann [J. Chem. Phys. 117, 3059 (2002)], for both the (5)1g and (3)O(+)(g) states of Xe2. These spectra exhibit the most extensive vibrational development, and provide evidence for the first molecular core-switching transition, observed to date for any of the rare gas dimers at small R (<4 Ǻ). Experiments in the green (545-555 nm) also provide improved absorption spectra, relative to data reported in 1986 and 1999, associated with Xe2 Rydberg states derived from the Xe(7p) orbital.

Linkage of oxygen deficiency defects and rare earth concentrations in silica glass optical fiber probed by ultraviolet absorption and laser excitation spectroscopy.

Ultraviolet absorption measurements and laser excitation spectroscopy in the vicinity of 248 nm provide compelling evidence for linkages between the oxygen deficiency center (ODC) and rare earth concentrations in Yb and Er-doped glass optical fibers. Investigations of YAG-derived and solution-doped glass fibers are described. For both Yb and Er-doped fibers, the dependence of Type II ODC absorption on the rare earth number density is approximately linear, but the magnitude of the effect is greater for Yb-doped fibers. Furthermore, laser excitation spectra demonstrate unambiguously the existence of an energy transfer mechanism coupling an ODC with Yb(3+). Photopumping glass fibers with a Ti:sapphire laser/optical parametric amplifier system, tunable over the 225-265 nm region, or with a KrF laser at 248.4 nm show: 1) emission features in the 200-1100 nm interval attributable only to the ODC (Type II) defect or Yb(3+), and 2) the excitation spectra for ODC (II) emission at ~280 nm and Yb(3+) fluorescence (λ ~1.03 µm) to be, within experimental uncertainty, identical. The latter demonstrates that, when irradiating Yb-doped silica fibers between ~240 and 255 nm, the ODC (II) defect is at least the primary precursor to Yb(3+) emission. Consistent with previous reports in the literature, the data show the ODC (II) absorption spectrum to have a peak wavelength and breadth of ~246 nm and ~19 nm (FWHM). Experiments also reveal that, in the absence of Yb, incorporating either Al(2)O(3) or Y(2)O(3) into glass fibers has a negligible impact on the ODC concentration. Not only do the data reported here demonstrate the relationship between the ODC (II) number density and the Yb doping concentration, but they also suggest that the appearance of ODC defects in the fiber is associated with the introduction of Yb and the process by which the fiber is formed.

Effect of different promoters on immune responses elicited by HIV-1 gag/env multigenic DNA vaccine in Macaca mulatta and Macaca nemestrina.

pCMV-NL(Deltapol) and pAKV-NL(Deltapol) expressed human immunodeficiency virus type 1 (HIV-1) gag and env under the regulation of the human cytomegalovirus (CMV) immediate-early (IE) promoter/enhancer and the endogenous AKV murine leukemia viral long terminal repeat (LTR), respectively. Analysis of the immune responses elicited by direct DNA injection of pCMV-NL(Deltapol) and pAKV-NL(Deltapol) in macaques indicated that generation of the humoral and T-cell proliferative responses correlated directly with the promoter strength of the vaccine DNAs. In Macaca mulatta, pCMV-NL(Deltapol) generated stronger humoral responses and T-cell proliferative responses to Gag and Env using less DNA and fewer number of injections than pAKV-NL(Deltapol). Similarly, in Macaca nemestrina pCMV-NL(Deltapol) elicited high humoral responses, which persisted long-term and were boostable. Injection of large amounts of pAKV-NL(Deltapol), in general, failed to produce antibody levels comparable to pCMV-NL(Deltapol). However, injection of a control animal with large amounts of vector DNA produced a generalized enzyme-linked immunosorbent assay (ELISA) reactivity to HIV-1. The results indicated that generation of high immune responses to HIV-1 cannot be achieved by increasing the vaccine DNA dose and may require high protein expression from the DNA by including a strong promoter or by the use of other boosting agents. Furthermore, safety concerns may arise with increasing the DNA dose that could need additional investigation.

The hyperalimentation treatment of peptic ulcer with amino acids (protein hydrolysate) and dextri-maltose

1. A hyperalimentation treatment with a high caloric and high amino acid (protein hydrolysate) mixture has been found to be efficacious in promptly bringing acute peptic ulcers to a state of quiescence2. It is also a prompt method of simultaneously rehabilitating the strength and body weight of the ulcer patient3. The prompt improvement appears to be due to the giving of a substance (protein hydrolysate) that is simultaneously an antacid and an easily assimilable food which can be built into tissues4. The treatment does not insure against recurrences when the patient reverts to old dietary habits5. In the course of this work, a protein deficiency has been demonstrated in a large percentage of peptic ulcer cases6. The suggestion is made that gastroenterologists try this treatment and compare the results with those obtained with other regimens now in use. (Summary and conclusions)

Sensitive assays for isolation and detection of simian foamy retroviruses.

Simian foamy viruses (SFVs) are highly prevalent in a variety of nonhuman primate species ranging from prosimians to apes. SFVs possess a broad host range, and human infections can occur by cross-species transfer (W. Heneine et al., Nat. Med. 4:403-407, 1998). Retrovirus screening of potential sources of infection, such as laboratory research animals and simian-derived biological products, could minimize human exposure to SFVs by reducing the risk of potential retrovirus infection in humans. We describe a variety of sensitive assays for SFV isolation and detection which were developed with a prototype strain of SFV serotype 2. The Mus dunni cell line (M. R. Lander and S. K. Chattopadhyay, J. Virol. 52:695-698, 1984) was found to be highly sensitive for SFV production on the basis of various general and specific retrovirus detection assays such as reverse transcriptase assay, transmission electron microscopy, immunofluorescence assay, and Western blotting. A highly sensitive PCR assay was developed on the basis of the sequences in primary SFV isolates obtained from pig-tailed macaques (Macaca nemestrina) and rhesus macaques (Macaca mulatta). Analysis of naturally occurring SFV infection in macaques indicated that analysis by a combination of assays, including both highly sensitive, specific assays and less sensitive, broadly reactive assays, is important for evaluation of retrovirus infection.

Screwworm eradication program in Central America.

The Screwworm Eradication Program has been extremely successful in its efforts to achieve its goal of eradication of screwworms through Central America and establishment of a permanent biological barrier in the eastern half of Panama. Following eradication of screwworms from Mexico in 1991, eradication was achieved in Belize in 1992, in Guatemala in 1993, and in El Salvador in 1994. Honduras has been free of screwworms since January 1995, and the number of cases in Nicaragua has dropped, as of April 1995, to about 4% of the average number of cases found during the period June-August 1993.

Screwworm eradication program in Central America

The Screwworm Eradication Program has been extremely successful in its efforts to achieve its goal of eradication of screwworms through Central America and establishement of a permanent biological barrier in the eastern half of Panama. Following eradication of screwworms from Mexico in 1991, eradication was achieved in Belize in 1992, in Guatemala in 1993, and in El Salvador in 1994. Honduras has been free of screwworms since Janaury 1995, and the number of cases in Nicaragua has dropped, as of April 1995, to about 4 percent of the average number of cases found during the period June-August 1993. (AU)

A highly divergent simian immunodeficiency virus (SIVstm) recovered from stored stump-tailed macaque tissues.

We report here the results of molecular analysis of a simian immunodeficiency virus (designated SIVstm) which was isolated from a rhesus monkey inoculated with stored lymph node tissue of an Asian stump-tailed macaque. The latter monkey had died in 1977 during an epidemic of acquired immunodeficiency and lymphoma at the California Regional Primate Research Center (L. J. Lowenstine, N. W. Lerche, P. A. Marx, M. B. Gardner, and N. C. Pedersen, p. 174-176, in M. Girard and L. Valette, ed., Retroviruses of Human AIDS and Related Animal Viruses, 1988). Nucleotide sequence analysis of the gag and env regions indicates that SIVstm is an ancient member of the SIV/human immunodeficiency virus type 2 group; it is quite divergent from known SIVs isolated from African sooty mangabeys as well as from Asian macaques. Furthermore, of all SIV strains described to date, SIVstm is the most closely related to human immunodeficiency virus type 2.

SIV of stump-tailed macaque (SIVstm) is a divergent Asian isolate.

Analysis of molecularly cloned DNAs of SIVs isolated from Asian rhesus macaque (Macaca mulatta; SIVmac) and pig-tailed macaque (Macaca nemestrina; SIVmne) has indicated a high degree of sequence homology between these viruses. Thus SIVmac and SIVmne might have originated from the same or very closely related viruses. We have cloned and sequenced a PCR-amplified segment containing the LTR sequences of SIV originating from a stump-tailed macaque (Macaca arctoides; SIVstm). Comparative sequence analysis indicates that SIVstm belongs to the SIV/HIV-2 group; however, it is genetically distinct from the other members.

Sodium pentosan polysulfate (PPS), an anti-HIV agent also exhibits synergism with AZT, lymphoproliferative activity, and virus enhancement.

Sodium pentosan polysulfate (PPS), a negatively charged polymer of beta-D-xylopyranose units, was evaluated for its anti-HIV effects in normal human peripheral mononuclear cells (PMNC) and its possible synergism with AZT. In the presence of 25 nM AZT, 2.0 micrograms/ml of PPS reduced HIV-1 replication 110-fold, compared with a 3.9- and 7-fold decrease in the presence of either drug individually. Surprisingly, at low (below 1 microgram/ml) concentrations of either PPS or dextran sulfate, an enhancement of virus production was observed. PPS was nontoxic, had a proliferative effect on uninfected and a protective effect on infected PMNC. Virus enhancement at low concentrations of PPS appeared to be linked to its lymphoproliferative effect. These findings suggest that the use of PPS and others such agents as monotherapy for AIDS might have deleterious effects. However, due to its marked synergism with AZT and its lymphoproliferative activities, PPS might prove to be a useful agent in therapeutic trials of AIDS if used in combination with less than the usual dosage of AZT.

Nourishing the HIV-infected adult.

Malnutrition of protein, calories, and micronutrients can magnify the immunosuppression of HIV. The goal of nutritional therapy in the HIV-infected population is the maintenance of optimal nutritional status. This may not always be realistic because of the vast number of nutrition-related problems that can occur. In some cases a more appropriate goal is the prevention of further depletion. This is preferably accomplished by intake of a well-balanced diet with the use of a one-a-day type multivitamin if necessary. Tube feedings or parenteral nutrition may be required if oral intake is insufficient. Restricted diets that severely limit food choices may impede adequate intake. Vitamin and mineral megadoses should be avoided because they can impair immunity as well as general biological functioning. The roles of nurses and dietitians are often enmeshed. Nurses are frequently the first to identify nutrition-related problems as part of their daily care of clients. They often augment the nutritional counseling provided by the dietitians. In certain instances, they may be the sole provider of nutrition information. It is therefore important for nurses to have an understanding of the nutritional problems in HIV infection. The responsibility of all health care professionals is the provision of accurate information given in a creative, supportive, and nonjudgmental fashion. This approach can best contribute to patient comfort and health and will foster a trusting and effective relationship.

Liver fluke infections of cattle in Mali. An abattoir survey on prevalence and geographic distribution.

Six hundred and ninety two cattle, slaughtered in various abattoirs in Mali between August 1983 and November 1984 were examined for evidence of Fasciola gigantica and Dicrocoelium hospes infections. A great variation in geographic prevalence was observed. Sufficient knowledge was acquired to demonstrate both the importance of fascioliasis in some areas and also the high prevalence of D. hospes in other areas. We suggest that the difference in prevalence from one geographic area to another is influenced by local climatic conditions, presence or absence of rivers and lakes, and differences in livestock management practices by various ethnic groups.

Education for health sciences/biomedical librarianship: past, present, future.

This paper offers an analysis of and some predictions for the fields of library education and medical librarianship. The recent past of education for medical/health sciences librarianship is outlined, with emphasis on the changing nature of the library school, its faculty, and its students. The present situation is described, with specific reference to faculty, curriculum, and accreditation issues. A future agenda is proposed, identifying the need for interdisciplinary and cooperative efforts within the larger realms of medical informatics, high technology, a variety of health professions, and the community of contemporary library practice.