ABSTRACT
BACKGROUND: Ageing and its consequences on quality of life is one of the main issues to be addressed by public organizations; therefore the development of tools for its evaluation is a priority issue to orientate lines of action. Therefore, the objective of this research is to carry out cross-cultural adaptation and present the psychometric properties of the Spanish version of the Older People's Quality of Life Questionnaire-Brief (OPQOL-Brief). METHODS: a cross-cultural adaptation was carried out together with a process of translation and back-translation of the scale. The OPQOL-Brief and a sociodemographic questionnaire were administered to 120 older adults aged over 65 from a healthcare setting in the region of Extremadura. RESULTS: the exploratory analysis revealed a factor structure through a matrix of polychoric correlations divided in two intercorrelated factors, consisting of 12 items and with excellent sample adequacy indices (KMO = 0.846'; Bartlett test = 1268.1; p = 0.000). Then, the confirmatory factor analysis established the definitive model with exceptional goodness-of-fit indices (NNFI = 0.99; CFI = 0.99; CMIN/DF = 0.96; Ρ (χ2) = 0.22; RMSEA = 0.037 and RMSR = 0.040). Finally, Cronbach's alpha and McDonald's omega for internal consistency reported good values of 0.830 and 0.851, respectively. CONCLUSION: our findings show that the OPQOL-Brief exhibits a solution with 12 elements and related constructs, providing stable goodness-of-fit indicators as well as good and remarkable consistency ratings.
Subject(s)
Cross-Cultural Comparison , Quality of Life , Humans , Aged , Psychometrics , Reproducibility of Results , Aging , Surveys and QuestionnairesABSTRACT
Type 2 diabetes is a complex chronic disease that requires ongoing monitoring by an interprofessional team to prevent complications. The INMED (INterprofessional Management and Education in Diabetes) care pathway was developed by our team to optimize primary care services for these patients and their families. The objective of this study is to describe the preliminary results of its adoption and implementation. The INMED care pathway is organized into four axes: (a) continuing professional education, (b) self-management support, (c) case management, and (d) ongoing evaluation of the quality of diabetes care and services. A multiple-case study is underway to document its effects on practice change using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. Preliminary results on the adoption and implementation revealed some strengths: (a) regular patient follow-up by the case manager, (b) scheduling of physician appointments when required, and (c) regular screening for risk factors. Barriers were also identified: (a) lack of clear understanding of the case manager role, (b) lack of referrals to team members, and (c) lack of use of the motivational interview approach. The INMED care pathway is being adopted by primary care teams but challenges need to be overcome to improve its reach and effectiveness.
Subject(s)
Diabetes Mellitus, Type 2 , Physicians , Humans , Diabetes Mellitus, Type 2/therapy , Interprofessional Relations , Delivery of Health Care , Patient Care TeamSubject(s)
C-Reactive Protein/analysis , Fibromyalgia/blood , Serum Amyloid P-Component/analysis , Female , HumansABSTRACT
Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain and is associated with elevated systemic inflammatory biomarkers, and an elevated innate cellular response. The aim of this study was to determine if fibromyalgia patients have altered ability to release pro-inflammatory chemokines by isolated neutrophils and monocytes. The study participants were women diagnosed with FM (n = 6) and a control group of healthy women (HW) (n = 6). Supernatant concentrations of eotaxin (CCL11), human macrophage-derived chemokine (MDC) (CCL22) and growth regulated-oncogene (GRO-α) (CXCL1) released by both monocytes and neutrophils either resting or stimulated by LPS were determined by ELISA and compared between the FM and HW groups. Both resting and activated monocytes from FM patients released more eotaxin, MDC and GRO-α than those from HW. However, there were no significant differences in the release of chemokines from neutrophils of FM patients and the ones from healthy women. In conclusion, monocytes from women with FM are deregulated, releasing higher amounts of eotaxin, MDC and GRO-α than healthy individuals. This fact does not occur in neutrophils from women with FM.
Subject(s)
Chemokine CCL11/metabolism , Chemokine CCL22/metabolism , Chemokine CXCL1/metabolism , Monocytes/immunology , Neutrophils/immunology , Adult , Cells, Cultured , Female , Fibromyalgia , Humans , Immunity, Innate , Middle Aged , Phagocytosis/immunology , Pilot Projects , Young AdultABSTRACT
Los marcadores genéticos del pelaje y malformaciones óseas han permitido caracterizar el perfil genético de más de 400 poblaciones del gato doméstico alrededor del mundo. Hace 15 años se estableció dicho perfil en la ciudad de Cali (Colombia). En este estudio se determinó si el norte y sur de Cali se comportan como subpoblaciones y se comparó el perfil total con el estudio pasado. Se encontró una disminución de la frecuencia alélica de a (no-agouti) y d (dilution), pero un aumento en cinco, especialmente en l (longhair) y c s (siamese). Dichas diferencias pueden atribuirse a la selección humana de características más atractivas y por el flujo génico resultante del crecimiento demográfico de la ciudad, lo que explicaría también el primer reporte de los alelos inhibitor y ticked abyssinian. Se evaluó el equilibrio Hardy-Weinberg para el norte, sur y las dos zonas juntas, usando los loci white spotting y orange, encontrándose desequilibrio en este último para las tres zonas evaluadas debido a un déficit de heterocigotos. Norte y sur se dividieron en dos, y cada sub-muestra presentó equilibrio Hardy-Weinberg, aunque las diferencias en las frecuencias alélicas y heterocigosidades resaltaron microestructura geográfica y una relación entre tiempo de fundación del barrio y heterocigosidad. Norte y sur resultaron ser una población y no subpoblaciones (F ST= 0,0004, D= 0,0017), al igual que las nueve poblaciones colombianas con las que se comparó la presente ciudad. Se sugiere realizar un análisis microgeográfico de flujo génico y la definición de posibles colonias de gatos en Cali.
The coat genetic markers and skeleton abnormalities have allowed characterize the profile from more than 400 domestic cat populations around the world. 15 years ago, that profile was established in the city of Cali (Colombia). In this study it was determined if north and south of the city are subpopulations and it was compared the total profile against past study. A decrease in allele frequency of a (non-agouti) and d (dilution) was found, but an increase of five alleles was found, especially in l (long hair) and c s (siamese). These differences could be attributed to human selection of more attractive characteristics and gene flow resulting from demographic growth city, which would also explain the first report of inhibitor and ticked abyssinian alleles. Hardy-Weinberg equilibrium was evaluated for the north, south and both areas together, using white spotting and orange loci, determining disequilibrium in orange for the three evaluated areas due to a heterozygotes deficit. North and south were divided into two, each sub-sample showed Hardy-Weinberg equilibrium, although allele frequencies and heterozygosities highlighted microgeographic structure and a relationship between founding time of the neighborhood and heterozygosity. North and south are a single population and aren´t subpopulations (F ST= 0,0004, D= 0,0017), as well as nine Colombian populations with which this city was compared. It is suggested to make a microgeographical gene flow analysis and the definition of possible cat colonies in Cali.
ABSTRACT
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