[Dependence of the bactericidal activity and mutant selection of 4-quinolones on their serum concentration levels]. / Abhängigkeit von Bakterizidie und Mutantenselektion bei 4-Chinolonen von deren Serumkonzentrationsverläufen.

In an in vitro system, bacterial cultures were exposed to concentrations following the kinetics of 4-quinolones in human serum. Both killing kinetics of staphylococci and enterococci and selection of resistant mutants were shown to be influenced by the pharmacokinetik parameters of the individual substances.