ABSTRACT
BACKGROUND: Although non-diphtheria corynebacteria have traditionally been regarded as avirulent members of human bacterial flora, their pathogenic potential is increasingly recognized in our time. Reasons for this include the prolonged survival of severely ill and immunocompromised patients, the development of more invasive diagnostic and therapeutic procedures and the sub-optimal use of antibiotics that disrupts normal microbial balance and favors superinfections. CASE REPORT: We present a rare case of sepsis due to multidrug-resistant Corynebacterium striatum in a 76-year-old host. The patient suffered from myelodysplastic syndrome and was on corticosteroid treatment due to atopic dermatitis. He had, also, a recent hospital admission and received a course of broad-spectrum antibiotics due to lower respiratory infection. The patient responded neither to empiric nor to targeted treatment and finally succumbed. CONCLUSION: Diphtheroids are emerging pathogens capable of causing severe opportunistic infections. Their multidrugresistant nature renders treatment problematic and poses a threat to the currently established antimicrobial stewardship programs. Hippokratia 2016, 20(1): 67-69.
Subject(s)
Cholestasis/etiology , Echinacea/adverse effects , Hepatitis/diagnosis , Phytotherapy/adverse effects , Acute Disease , Adult , Humans , MaleSubject(s)
Anticoagulants/therapeutic use , Drug-Related Side Effects and Adverse Reactions , Heparin, Low-Molecular-Weight/adverse effects , Polysaccharides/administration & dosage , Thrombocytopenia/drug therapy , Aged , Anticoagulants/adverse effects , Arthroplasty, Replacement, Hip , Dose-Response Relationship, Drug , Fondaparinux , Humans , Polysaccharides/therapeutic use , Postoperative Complications , Thrombocytopenia/chemically induced , Treatment OutcomeABSTRACT
BACKGROUND/AIMS: Alpha-1 antichymotrypsin (ACT), a serine proteinase inhibitor, has been implicated in vascular pathology. The TT genotype of the ACT signal peptide A/T polymorphism has been reported to confer susceptibility to primary intracerebral hemorrhage (PICH). We conducted a prospective study to test possible association of ACT signal peptide A/T polymorphism with PICH in a Greek cohort with enough power (80%) to detect a twofold increase in the odds ratio. METHODS: We prospectively recruited 147 patients with PICH. ACT signal peptide A/T genotypes were determined in patients and 206 healthy, age- and sex-matched control subjects from the neurology outpatient clinic using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS: Our study did not show an association between ACT signal peptide A/T polymorphism and PICH. We also failed to find any influence on age at onset, the location and volume of PICH as well as on clinical severity at admission or 6-month outcome. CONCLUSION: Our data failed to confirm an association between ACT signal peptide A/T polymorphism and PICH. However, we cannot exclude the possibility that the TT genotype confers susceptibility at less than a twofold increase.
