Endopleura uchi - A review about its nutritional compounds, biological activities and production market.

Endopleura uchi (Huber) Cuatrec, known as uxi, is a native plant from the Amazon region, which has been used by locals for some pathology treatments. This review aimed to find the main uxi studies carried out in scientific literature. This compilation includes the biological activities that have been proven, parts of the plant that were exploited, as well as its nutritional properties. Uxi fruit has compounds, such as vitamins A and E, minerals, bioactive phenolic and organic acids, along with anti-inflammatory, antioxidant, antibacterial, antidiabetic, and anti-cholesterol actions. Some E. uchi extract activities have been reported, such as: α-glucosidase and cyclooxygenases (COX1/COX2) inhibitions, in addition to anti-bactericidal properties. The isocoumarin compound, bergenin is responsible for many of the reported biological activities of this species. E. uchi can be used for manufacturing products in food, pharmaceutical, and cosmetic industries, demonstrating its worth, regional economic growth, along the potential to dominate the worldwide market.

Relações entre Clínica e Osteopatia / Relations between Internal Medicine of the Osteopathy

Este estudo teve como objetivo, evidenciar aspectos comuns entre a Clínica Médica e a Osteopatia, comparando exigências, interações e semelhanças. Sendo que, ambas tem como objetivo principal a busca da saúde e qualidade de vida. Embora atuem com conceitos diferentes, têm conhecimentos anatâmicos, fisiológicos, semiológicos comuns, que devem ser sempre centrados num único propósito: a restauração e manutenção da integridade física, moral ou social do homem

Mites in clinical stool specimens: potential misidentification as helminth eggs.

We report the finding of unexpected microscopic oval structures in clinical stool samples processed by AFIP/Medicina Laboratorial, a laboratory performing routine clinical analysis in São Paulo, Brazil. Surprisingly, these objects were identified as mite eggs, sometimes accompanied by adult mites. Because misidentification of mite eggs as helminth ova may lead to erroneous treatment with far-reaching consequences, we sought to verify the frequency of adult mites and mite eggs among a number of processed stool specimens. Given their similarity to some helminth eggs, it is important that clinical laboratories recognize these structures, especially in geographic regions where intestinal parasitosis is prevalent.

Total plasmatic homocysteine and von Willebrand factor in experimental diabetes mellitus.

OBJECTIVES: To determine the plasma homocysteine and von Willebrand factor levels as markers of endothelial dysfunction in rats with diabetes mellitus induced by streptozotocin. METHODS: Thirty-five adult male rats (Rattus norvegicus albinus) (weight between 180-200 g) were randomized into three groups: control group (n=10), which received no drugs or vehicles; sham group (n=10), which received streptozotocin solution; and diabetic group (n=15), which received streptozotocin. Eight weeks after diabetes mellitus induction, the animals were weighed and anesthesized; blood samples were collected from abdominal aorta for plasma total homocysteine, von Willebrand factor and glucose levels. RESULTS: The experimental model was reproducible in 100% of animals. The mean plasma homocysteine levels were: 7.9 micromol/l (control), 8.6 micromol/l (sham) and 6.1 micromol/l (diabetic), with difference among the groups (p<0.01). Multiple comparison analysis among the groups showed that values in the diabetic group were lower than in the sham group (p<0.01). The mean von Willebrand factor values were 0.15 U/l (control), 0.16 U/l (sham) and 0.18 U/l (diabetic), with difference among the groups (p=0.03). The mean value was higher in the diabetic group than in the control group (p<0.05). Correlation between homocysteine and von Willebrand factor was not observed in the diabetic group. CONCLUSION: Reduced homocysteine levels and increased von Willebrand factor levels were observed in diabetes mellitus induced by streptozotocin; nevertheless, there were no correlations between them and with final glucose levels.

Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus.

Sleep is hypothesized to play a restorative role on immune system. In addition, disturbed sleep is thought to impair host defense mechanisms. Chronic sleep deprivation is a common occurrence in modern society and has been observed in a number of chronic inflammatory conditions, such as systemic lupus erythematosus (SLE). New Zealand Black/New Zealand White (NZB/NZW) F1 mice develop an autoimmune disease that strongly resembles SLE in humans, exhibiting high titers of antinuclear antibodies associated with the development of rapidly progressive and lethal glomerulonephritis. On the basis of this evidence, the present study examined the onset and progress of lupus in as-yet healthy female mice submitted to sleep deprivation. Sleep deprivation was accomplished by two 96-h periods in the multiple-platform method when mice were 10 wk old, and they were observed until 28 wk of age. Blood samples were collected from the orbital plexus fortnightly to evaluate serum antinuclear antibodies and anti-double-stranded DNA. Proteinuria and longevity as well as body weight were also assessed. The results indicated that mice submitted to sleep deprivation exhibited an earlier onset of the disease, as reflected by the increased number of antinuclear antibodies. However, no statistical difference was found in the other parameters analyzed. According to these results, sleep deprivation could be considered as a risk factor for the onset but not for the evolution of the disease.