ABSTRACT
Antibacterial properties of the Soviet drug nitazol which is a derivative of imidazole were studied. It was shown that nitazol in a dose of 4-8 micrograms/ml was highly active against gram-negative nonsporulating anaerobes, gram-positive anaerobic cocci and spore-forming Clostridia spp. Unlike metronidazole, it was efficient against both standard and clinical strains of facultative anaerobes such as E. coli, S. aureus and Klebsiella spp. isolated from patients with peritonitis and being poly-resistant to antibiotics. It was found in vitro that the antibacterial effect of nitazol was higher when it was used in combination with some antibiotics. It was demonstrated on experimental models of peritonitis caused by Staphylococcus spp. and E. coli in mice that nitazol used alone or in combination with gentamicin had a favourable effect on the animal survival and lifespan. The combination of nitazol with gentamicin was applied in the combined treatment of appendicular peritonitis in 80 children and its high therapeutic efficacy was stated. Nitazol is useful as an antibacterial drug in the combined treatment of children with purulent peritonitis.
Subject(s)
Disease Models, Animal , Escherichia coli Infections/drug therapy , Gentamicins/therapeutic use , Imidazoles/therapeutic use , Peritonitis/drug therapy , Staphylococcal Infections/drug therapy , Animals , Anti-Infective Agents/therapeutic use , Child , Drug Evaluation, Preclinical , Drug Therapy, Combination , Gentamicins/administration & dosage , Humans , Imidazoles/administration & dosage , MiceABSTRACT
The authors have examined about 100 patients of the surgical department and studied biological properties and virulence of 40 staphylococcus strains and 10 blue-pus bacillus strains. The data obtained evidence that the incidence of the virulence factors in the staphylococcal strains isolated from the pathological material has grown, the number of strains possessing the hemolytic and plasmocoagulase activity as well as the property to produce pigment being increased. Changes in the biological properties of microorganisms are, probably, induced by the chemotherapeutic action of drugs and, first of all, of antibiotics, that may be used when elaborating up-to-date methods for treatment of pyo-inflammatory diseases.
Subject(s)
Pseudomonas aeruginosa/physiology , Staphylococcus aureus/physiology , Surgical Procedures, Operative , Animals , Humans , Lethal Dose 50 , Mice , Pseudomonas aeruginosa/cytology , Pseudomonas aeruginosa/isolation & purification , Staphylococcus aureus/cytology , Staphylococcus aureus/isolation & purification , VirulenceABSTRACT
The experimental-clinical investigations have demonstrated the high effectiveness of the native preparation Nitazole against the Gram-negative non-spore-forming anaerobic bacteria, Gram-positive anaerobic cocci, spore-forming Clostridium, certain facultative anaerobes. This permits to recommend it for the use as an antibacterial preparation for the treatment of peritonitis in children.