ABSTRACT
Uterine leiomyomata present major problem for females. Although they are benign tumors their frequency is associated with many symptoms like infertility, abdominal pain, menorrhagia. Authors based on their own morphological studies and review of the literature try to indicate main factors causing angiogenesis within leiomyomata and its influence on tumor growth. The strongest proangiogenic factor seems to be hypoxia, which stimulates up- and down-regulation of numerous genetically determined substances. Also mechanical pressure acting upon newly growing vessels is one of the factors which may determine formation of so called "vascular pseudocapsule" around the lesion.
Subject(s)
Angiogenesis Inducing Agents/metabolism , Leiomyoma/blood supply , Myometrium/blood supply , Uterine Neoplasms/blood supply , Uterus/blood supply , Female , Humans , Intercellular Signaling Peptides and Proteins/metabolism , Neovascularization, Pathologic , Vascular Endothelial Growth Factors/metabolismABSTRACT
Anatomy of the vascular system of the leg was studied using classical anatomical dissection methods. Based also on literature we have reviewed the current knowledge on the vascularization of the lower leg and its embryological background with special respect toward the posterior tibial artery and its branches.
