[Biochemical characteristics of the brain mediator systems during stimulation of metastasis from surgical removal of a tumor]. / Viokhimicheskaia kharakteristika mediatornykh sistem golovnogo mozga v usloviiakh stimuliatsii metastazirovaniia pri khirurgicheskom udalenii opukholi.

In cases of tumor surgical operation, which stimulated metastatic spreading, distinct activation of hypothalamic structures was observed simultaneously with generalization of impairments in the neurotransmitting systems, accompanied by their exhaustion and disturbance. Pathology-related alterations in brain neurotransmitting reactions, provoked by surgical operation in cases of tumors, considerably exceeded similar parameters in non-operated or sham-operated animals.

[The effect of Leu- and Met-enkephalins on the adenosine deaminase and 5'-nucleotidase activities of the lymphocytes under conditions of stress stimulation of metastasis]. / Vliianie lei- i met-énkefalinov na aktivnost' adenozindezaminazy i 5'-nukleotidazy limfotsitov v usloviiakh stressornoi stimuliatsii metastazirovaniia.

A correlation between changes of the hypothalamic mediator processes, hormone level in blood plasma, catecholamines and their catabolites in urine and changes of the activity of adenosine metabolism enzymes in the thymus and the spleen lymphocytes has been observed in C57B1 mice with Lewis lung carcinoma. Effect of leu- and met-enkephalines on neuroendocrine stress-realizing mechanisms proved to be different, that is responsible for their contrary effect on the metastatic growth--leu-enkephaline inhibits and met-enkephaline stimulates the process. It has been shown that an inhibitory effect of leu-enkephaline is greatly related to its stimulating influence on the thymus lymphocyte activity and a decrease of the functional activity of the spleen lymphocytes.

[Comparative study of the effectiveness of immunoelectron microscopic methods for detecting rotaviruses and the hepatitis A virus]. / Sravnitel'noe issledovanie éffektivnosti immunoélektronno-mikroskopicheskikh metodov vyiavleniia rotavirusov i virusa gepatita A.

Different variants of immune electron microscopy method used for the detection of rotaviruses and hepatitis A virus in specimens from patients were compared. Immune electron microscopy using filtration into agar was shown to be the optimal method for diagnosis of such prevalent infections as rotavirus gastroenteritis and viral hepatitis A.

[Effect of ruthenium red on the induction by Ca2+ ions of the beta- and gamma states of comuton regulation of mitochondrial respiration and oxidative phosphorylation]. / Vliianie ruteniia krasnogo na induktsiiu beta- i gamma-sostoianii komutonnoi reguliatsii dykhaniia i okislitel'nogo fosforilirovaniia mitokhondrii ionami Ca2+.

Preincubation of liver mitochondria (Mch) with Ca2+ ions at inorganic phosphate concentration less than I mM in the presence of liver cell soluble phase (CSP) induced rotenone-independent tissue-specific uncoupling of oxidative phosphorylation (beta state of comuton regulation) and rotenone-stimulated tissue-specific uncoupling (gamma state of comuton regulation). The reduction in K+ ion concentration in the incubation medium entirely inhibited the induction of beta state. Tissue-specific stimulation of the rat liver Mch respiration in substrate-containing medium was increased after rotenone addition. Ruthenium red was added to the medium before and after the end of Mch preincubation with Ca2+ in the presence of CSP. The results suggest that limited Ca2+ transport in Mch is necessary for the induction of beta and gamma states of comuton regulation. Ca2+ ejected from Mch also participates in the induction of beta state of comuton regulation. Comuton receptor on the mitochondrial membrane surface is devoid of glyco- and mucoprotein components bound by ruthenium red.