ELEVATED LEVELS OF NATURALLY OCCURRING AUTOANTIBODIES TO HUMAN CHORIONIC GONADOTROPIN Β CORE FRAGMENT IN A FEMALE PATIENT WITH THYROID FOLLICULAR ADENOMA: CASE REPORT.

We report a case of a woman, who had an elevated levels of naturally-occurring autoantibodies to human chorionic gonadotropin (hCG) ß core fragment ( hCGßcf) one year prior to the development of thyroid follicular lesion. The patient underwent surgery and the histology report demonstrated that the lesion was a follicular adenoma. Further investigations of the role of naturally-occurring autoantibodies (NAAbs) to anti-hCGßcf in the pathogenesis of various tumours of thyroid gland might be useful in the development of novel diagnostic methods, using anti-hCGßcf NAAbs as a marker for the detection of unsuspected thyroid tumour.

The possible use of V. parahaemolyticus - specific bacteriophages for prevention and therapy of infections caused by V. parahaemolyticus.

Vibrio parahaemolyticus is the most common halophilic Vibrio species causing serious gastroenteritis in humans. The main source of infection is consumption of undercooked or raw seafood or exposure to contaminated water. The monitoring conducted in 2006-2008 demonstrated that warm, subtropical climate and low- to moderate salinity of water in the Black Sea coastal zone provides a favorable environment for growth and spread of V. parahaemolyticus bacteria. Antibiotics are commonly applied for control V.parahaemolyticus infections in humans. However, with the growing problem with bacterial antibiotic-resistance search for alternative biological anti-infectives, such as bacteriophages, becomes more actual. The aim of the presented work was characterization of V. parahamolyticus- specific bacteriophages in relation with their possible use for treatment and prevention of food and waterborne gastroenteritis in humans infected with V.parahaemolyticus. 69 bacteriophages specific to V.parahaemolyticus were isolated from different water sources and 5 of them were characterized according to their virion morphology, host-range, temperature and pH dependence. Stability of phages in different media and solutions, also susceptibility to action of a number of protolithic enzymes was studied as well. Obtained results showed that studied bacteriophages can be used for preparation of phage mixture as a potential therapeutic preparation against V.parahaemolyticus associated infections.

[Participation of myoepithelial cells in the histogenesis of breast cancer]. / Ob uchastii mioépitelial'nykh kletok v gistogeneze raka molochnoi zhelezy.

The structural and functional features of myoepithelial cells of the intact mammary gland, dyshormonal dysplasias and parenchymatous elements of lobular carcinoma of this organ were studied and compared for the purpose of the elucidation of controversial issue of the role of myoepithelial cells in histogenesis of mammary gland carcinoma. Some distinctive histological (selective staining with amido black--tannin acid), enzyme-chemical (high adenosine-triphosphatase activity), and ultrastructural (cytoplasmic fibrils with focal consolidations, pinocytic vesicles) features of myoepithelial cells were determined. The detection of similar properties in parenchymatous elements of lobular carcinoma facilitated the determination of the tumor cytogenetic profile and suggested the myoepithelial origin of a certain part of carcinoma parenchyma.