ABSTRACT
The results of application of systemic cytokinotherapy and splenopid in patients, operated on for an acute calculous cholecystitis, are presented. While in patients of a control group the conventional basic therapy was conducted, to the patients of the main group the systemic cytokinotherapy and splenopid were conducted preoperatively and postoperatively on background of basic therapy during 3-10 days at average. In both groups preoperatively the reduction of interleukin-2 (IL-2) and gamma-interferon (IFNgamma) content were observed, as well as raising of the blood level of the tumor necrosis factor-alpha (TNF-alpha), IL-6 and IL-10. In the patients of a control group a tendency towards the studied indices normalisation was noted postoperatively, and in the patients of the main group the elimination of the organism cytokine state dysbalance was achieved. While doing comparative analysis of ratio of TNF-alpha/IL-10 and IL-2/IL-10 in the blood serum in the main group there was established, that up to the observation period end the both indices were close to the norm.
Subject(s)
Cholecystitis, Acute/surgery , Cytokines/blood , Gallstones/surgery , Immunologic Factors/therapeutic use , Immunotherapy/methods , Adolescent , Adult , Aged , Cholecystitis, Acute/complications , Cholecystitis, Acute/immunology , Gallstones/complications , Gallstones/immunology , Humans , Immunologic Factors/administration & dosage , Middle Aged , Treatment Outcome , Young AdultABSTRACT
The article describes 163 patients with foreign bodies in the gastro-intestinal tract. The operative method of treatment was used in 57 patients. Urgent operations were performed in 34 patients with multiple foreign bodies and symptoms of peritonitis. Simple operations were used in 23 patients with fixed or immobile foreign bodies.
Subject(s)
Digestive System , Emergencies , Foreign Bodies/surgery , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Foreign Bodies/diagnostic imaging , Foreign-Body Migration , Humans , Infant , Male , Middle Aged , RadiographySubject(s)
Spleen/surgery , Splenic Rupture/surgery , Wounds, Stab/surgery , Humans , Omentum/transplantation , Spleen/injuries , SplenectomyABSTRACT
Advantages of the active surgical treatment are convincingly shown by the analysis of results of the treatment of 122 patients with purulent wounds and acute purulent diseases by traditional methods (opening the suppurative focus, drainage of the wound with gauze tampons) or the active surgical method (initial surgical treatment of the purulent wound or focus, drainage with a plastic tube, fractional or permanent washing of the wound) in combination with antibiotic therapy, application of enzymatic, antienzymatic and immunological agents.
