[The DIC syndrome in severe trauma to the skull and brain]. / DVS-sindrom pri tiazheloi travme cherepa i golovnogo mozga.

The article is based on the analysis of the hemocoagulation system in 205 patients (91 with contusion of the brain without compression and 114 with compression). Evaluation of the clinical signs, hemocoagulation disorders, and pathophysiological data revealed 89 (43.4%) cases of the disseminated intravascular coagulation syndrome. Besides other factors, exhaustion of the functioning of the anticoagulation ability of the blood in increased functioning of the coagulation system promoted the development of the syndrome. The syndrome was encountered mostly in the mesencephalobulbar (in 33 among 42 cases) and the diencephalic (in 17 of 37 cases) forms of brain lesions and in subdural hematomas (in 33 among 47 cases). Total mortality was 30.2% (62 among 205), disseminated intravascular coagulation syndrome mortality was 55% (49 among 89 cases).

[The combined therapy of patients with severe craniocerebral injury]. / Kompleksnaia terapiia bol'nykh s tiazheloi cherepno-mozgovoi travmoi.

The hemostasis system was studied in 423 patients. Coagulation occurred in a definite sequence: its expressiveness and duration were determined by the severity and form of brain damage. In the period of hypercoagulative changes (from 2 to 15 days and longer), thrombotic processes were revealed in 16% of the cases. Anticoagulative treatment including heparin, indirect anticoagulants, des- and antiaggregates, as well as fibrinolytics were applied in 27% of the cases, which reduced mortality by 12%.