[The immune status of children with extrahepatic portal hypertension following splenectomy]. / Immunnyi status detei s vnepechenochnoi portal'noi gipertenziei posle splenéktomii.

The purpose of the work was to study the immune status and some nonspecific defense factors in children with extrarenal portal hypertension after splenectomy. Seventy-one children were examined. It was found that the T-lymphocyte count before and in the early periods after the operation in children with extrahepatic portal hypertension did not differ from that in the control group. At the same time, the changes in serum immunoglobulins depended on the stage of the examination. Study of other links of immunity also revealed the time course of changes in their values.

[The effect of splenectomy on the immune status of children with active liver cirrhosis]. / Vliianie splenéktomii na immunnyi status detei s aktivnym tsirrozom pecheni.

A complex study of parameters of the systemic cell humoral immunity, secretory immune system, functional state and phagocytic activity of neutrophils as well as activity of the complement and its C3, C4 components in 28 children with active cirrhosis of the liver has shown that the disease was accompanied by a generalized disturbance of the immunity mechanisms. Splenectomy in these children was shown to have favorable influence on the immune status, to reduce activity of the immunopathological process in the liver. At the same time, splenectomy results in continuous suppression of neutrophilic phagocytosis which may be a cause of the development of postsplenectomy septic conditions.