A computerized reminder strategy is effective for annual influenza immunization of children with asthma or reactive airway disease.

BACKGROUND: Influenza virus infection frequently triggers asthma exacerbation and hospitalization. Annual influenza immunization is recommended for children with chronic conditions, including those with asthma or reactive airway disease (RAD); however, <10% receive it each year. METHODS: In September, 1997, we instituted a computerized staged reminder strategy for annual influenza immunization of children with asthma/RAD at the Scott and White Pediatric Clinic in Temple. A reminder letter, followed six weeks later by an autodial recall telephone message, was sent to the parent/guardian of children with asthma/RAD using the Shared Medical Systems to identify children with asthma/RAD and the Integrated Client Encounter System to record immunizations. The effect of this computerized reminder system on the influenza immunization rate of a cohort of 925 Scott and White Pediatric Clinic children with asthma/RAD was examined for the 1996 to 1997 and 1997 to 1998 influenza seasons, before and after intervention. RESULTS: A significant increase in influenza immunization rate from 5.4% to 32.1% occurred in all age groups, regardless of the insurance status. The medically attended acute respiratory illness rate per 100 subjects was significantly higher in vaccinated than in unvaccinated children for each of the two influenza epidemics and in the period between the two epidemics. CONCLUSION: A computerized reminder letter followed by an autodial recall telephone message is effective in increasing the influenza immunization rate of children with asthma/RAD. Children with significantly higher respiratory morbidity during and in between two influenza epidemics were more likely to be immunized after receiving written and telephone autodial reminders.

Contribution of antibody to neutrophil-mediated killing of Enterococcus faecalis.

Late-onset septicemia due to Enterococcus faecalis is common among very low-birth weight neonates. These infants have low concentrations of placentally derived IgG and developmentally low levels of complement. The aim of the present study was to determine the contribution of antibody to in vitro neutrophil-mediated phagocytosis of E. faecalis. Antibody alone, as contained in an adult serum pool heated to inactivate complement, promoted only a modest reduction in the initial bacterial inoculum (50 +/- 12%) for 6 of 10 E. faecalis bacterial strains tested and allowed growth of the other four strains. In the presence of complement, NHS promoted > or = 90% reduction in the initial bacterial inoculum of two representative strains at serum concentrations as low as 0.5%. Hypogammaglobulinemic serum supported similar activity only at concentrations above 5%. Purification of IgG and IgM fractions from NHS revealed that IgM had the higher specific activity to promote phagocytic activity. Absorption to remove specific antibody significantly reduced bactericidal activity by normal human serum, complement-deficient sera, and hypogammaglobulinemic serum. Reconstitution of hypogammaglobulinemic serum with antibody as contained in 1% heated normal human serum or in immune globulin for intravenous use (1200 mg/dl) restored phagocytic activity. Thus, E. faecalis-specific antibody enhances PMN-mediated killing of this organism. Adjunctive therapy with intravenous immunoglobulin could augment the host response to enterococcal infections in infancy.

Clinical indicators of childhood retropharyngeal abscess.

Retropharyngeal abscess is a rare but distinctive cause of airway obstruction in childhood. Early recognition permits emergent airway management and surgical drainage. Even when the presentation is insidious and does not include respiratory compromise, early clinical diagnosis of retropharyngeal cellulitis and appropriate medical treatment may halt progression to an abscess. Delay in the diagnosis and management of a retropharyngeal abscess may lead to potentially lethal complications involving vital structures. A case of an infant whose diagnosis of retropharyngeal abscess was delayed because of absence of respiratory compromise is reported. Relapse of retropharyngeal abscess despite surgical drainage and appropriate antibiotic treatment was a complication of infection in this patient. Clinical indicators providing an early diagnosis of retropharyngeal infection, and aspects of evaluation, management, and outcome, are discussed.