Adjuvant chemotherapy, extent of resection, and immunoistochemical neuroendocrine markers as prognostic factors of early-stage large-cell neuroendocrine carcinoma.

BACKGROUND: We investigated whether adjuvant chemotherapy, extent of resection, and immunoistochemical neuroendocrine markers affected survival of patients with the early stage of large-cell neuroendocrine cancer. METHODS: This was a retrospective multicenter study including consecutive patients undergoing resection of node negative large-cell neuroendocrine carcinoma. Five-year survival and disease-free survival rate were evaluated by the Kaplan-Meier method and the log-rank test in relation to adjuvant chemotherapy, extent of resection, and immunoistochemical neuroendocrine markers (synaptophysin, chromogranin A, and neuron-specific enolase). RESULTS: Our study population included 117 patients; 47 (40%) of these received adjuvant chemotherapy. Patients treated with adjuvant chemotherapy had better survival (74% vs. 45%, p = 0.002) and disease-free survival (79% vs. 40%, p = 0.001) in all cases except patients with tumor <20 mm (79.5% vs. 57.4%, p = 0.43). Lobectomy compared to sublobar resection was associated with better survival (67% vs. 0.1%, p < 0.0001) and disease-free survival (65% vs. 0.1%, p < 0.0001) also in patients with tumor <20 mm (79% vs. 28%, p = 0.001). Patients with triple-positive neuroendocrine markers had better survival (79% vs. 35%, p = 0.0001) and disease-free survival (69% vs. 42%, p = 0.0008). Regression analysis showed that tumor size <20 mm, lobectomy, adjuvant chemotherapy, and triple-positive immunistochemical neuroendocrine markers were significant favorable prognostic factors for survival outcomes. CONCLUSIONS: Lobectomy seems to be the management of choice in patients with large-cell neuroendocrine cancer <20 mm while adjuvant chemotherapy should be administered only in patients with tumor >20 mm.

Effect Modification of Cardiorespiratory Fitness, Obesity, and Physical Activity in Adults.

We investigated if cardiorespiratory fitness modifies the association between obesity and the level of physical activity. In this cross-sectional study, we analyzed data from 746 adults, free of diagnosed cardiorespiratory or locomotor diseases. We analyzed sociodemographic and clinical information, cardiovascular risk factors, cardiorespiratory fitness, anthropometry, and level of physical activity (time spent in moderate-to-vigorous physical activity). Those that spent more time in moderate-to-vigorous physical activity were younger, male, with lower body mass index, without self-reported arterial blood hypertension, diabetes and dyslipidemia, non-smokers, and presented with better cardiorespiratory fitness. The linear regression coefficients showed that cardiorespiratory fitness changes according to the level of physical activity and body mass index (obesity in low cardiorespiratory fitness: ß 6.0, p=0.213, 95%CI-3.5 to 15.6; in intermediate cardiorespiratory fitness: ß 6.3, p=0.114, 95%CI-1.5 to 14.2; in high cardiorespiratory fitness: ß-6.3, p=0.304, 95%CI-18.4 to 5.8). This effect modification trend was present after adjusting the model by covariates. Cardiorespiratory fitness potentially modifies the association between body mass index and the level of physical activity. It should be routinely assessed to identify persons with overweight/ obesity with low/ intermediate cardiorespiratory fitness to prescribe individualized training.

Dynamic physiological responses in obese and non-obese adults submitted to cardiopulmonary exercise test.

PURPOSE: Obese individuals have reduced performance in cardiopulmonary exercise testing (CPET), mainly considering peak values of variables such as oxygen uptake ([Formula: see text]), carbon dioxide production ([Formula: see text]), tidal volume (Vt), minute ventilation ([Formula: see text]) and heart rate (HR). The CPET interpretation and prognostic value can be improved through submaximal ratios analysis of key variables like [Formula: see text], [Formula: see text], [Formula: see text] [Formula: see text] and oxygen uptake efficiency slope (OUES). The obesity influence on these responses has not yet been investigated. Our purpose was to evaluate the influence of adulthood obesity on maximal and submaximal physiological responses during CPET, emphasizing the analysis of submaximal dynamic variables. METHODS: We analyzed 1,594 CPETs of adults (755 obese participants, Body Mass Index ≥ 30 kg/m2) and compared the obtained variables among non-obese (normal weight and overweight) and obese groups (obesity classes I, II and III) through multivariate covariance analyses. RESULT: Obesity influenced the majority of evaluated maximal and submaximal responses with worsened CPET performance. Cardiovascular, metabolic and gas exchange variables were the most influenced by obesity. Other maximal and submaximal responses were altered only in morbidly obese. Only a few cardiovascular and ventilatory variables presented inconsistent results. Additionally, Vtmax, [Formula: see text], Vt/Inspiratory Capacity, Vt/Forced Vital Capacity, Lowest [Formula: see text], [Formula: see text], and the y-intercepts of [Formula: see text] did not significantly differ regardless of obesity. CONCLUSION: Obesity expressively influences the majority of CPET variables. However, the prognostic values of the main ventilatory efficiency responses remain unchanged. These dynamic responses are not dependent on maximum effort and may be useful in detecting incipient ventilatory disorder. Our results present great practical applicability in identifying exercise limitation, regardless of overweight and obesity.

DD Genotype and Atherosclerosis in Overweight Menopausal Women

Abstract Background Sex-specific pathology of coronary artery disease (CAD) has not been recognized. Women with obstructive or nonobstructive CAD associated with traditional risk factors have similar events; no studies have explored both populations in association with genetic markers. Objective To evaluate the DD genotype in overweight menopausal women and its association with CAD and traditional risk factors. Method This cross-sectional study included 356 menopausal women who underwent coronary angiography as CAD assessment. The patients' DNA was extracted and polymorphisms were detected with a single polymerase chain reaction assay. Two groups were formed based on luminal lesions (normal [n = 134] or pathological [n = 222]) with a cutoff value > 30%, considering overweight and age. The chi-square test, Student's t-test, and multivariate logistic regression were performed as appropriate (p < 0.05) using the following variables: overweight, diabetes, hypertension, dyslipidemia, smoking status, sedentary lifestyle, and a family history of CAD. Results The mean age of the sample was 63 + 8 years, and the mean BMI was 28 + 5 kg/m2. The DD genotype was slightly more prevalent in the pathological group (30.2% vs. 21.6%, p = 0.079), but this significantly changed when BMI > 25 was considered (33% vs. 18%, p = 0.012). In multivariate analysis with two threshold levels (> 50 and > 60 years), diabetes was significantly associated with CAD in both models (p = 0.021 vs. 0.009) but the genotype was only associated with younger age (p = 0.034). Conclusion These data support an association between atherosclerosis and the renin-angiotensin system in overweight menopausal women that is dependent on the age at which the ischemic event occurs.

Subxifoid versus transthoracic thoracoscopic lobectomy: Results of a retrospective analysis before and after matching analysis.

BACKGROUND: Here, we report our initial experience with subxifoid video-assisted thoracoscopic surgery (SVATS) lobectomy for the management of primary lung cancer, and compared the outcomes of SVATS with those of conventional transthoracic VATS (CVATS) lobectomies to validate its feasibility and usefulness. METHODS: The clinical data of consecutive patients undergoing VATS lobectomy via SVATS or CVATS for lung cancer were retrospectively compared. The endpoints were to evaluate the statistical differences in surgical results, postoperative pain (measured with visual analog scale [VAS] scores at 8 hours, Day 1, Day 2, Day 3, at discharge, one month and three months after surgery) and paresthesia (measured at one- month, and three months after surgery). The two groups were compared before and after matching analysis. RESULTS: Our study population included 223 patients: 84 in the SVATS and 139 in the CVATS group. The two groups were not comparable for sex (P = 0.001), preoperative comorbidity as cardiopathy (P = 0.007), BMI value (P = 0.003), left-sided procedure (P = 0.04), tumor stage (P = 0.04), and tumor size (P = 0.002). These differences were overcome by propensity score matching (PSM) analysis that yielded two well-matched groups which included 61 patients in each group. Surgical outcomes including blood loss, hospital stay and complications were similar before and after matching analysis, but SVATS compared to CVATS was associated with longer operative time before (159 ± 13 vs. 126 ± 6.3, P < 0.0001), and after matching analysis (161 ± 23 vs. 119 ± 8.3; P < 0.0001) and significant reduction of postoperative pain during the different time-points (P < 0.001), and paresthesia at one (P = 0.001), and three months (P < 0.0001). CONCLUSIONS: SVATS lobectomy is a feasible and safe strategy with surgical outcomes similar to CVATS lobectomy but with less postoperative pain and paresthesia. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: Subxifoid thoracoscopic lobectomy is a feasible and safe procedure, with potential benefits in terms of postoperative pain and paresthesia compared to conventional thoracoscopic lobectomy Our results showed that surgical outcomes including blood loss, hospital stay, morbidity and mortality are similar but subxifoid thoracoscopy was associated with significant reduction of postoperative pain and paresthesia. WHAT THIS STUDY ADDS: Subxifoid thoracoscopy is a safe procedure; compared to conventional transthoracic thoracoscopy, it avoids intercostal incisions, and spares nerve trauma, resulting in a reduction of postoperative pain and paresthesia.

Dipeptidyl Peptidase IV Inhibitors for Nonalcoholic Fatty Liver Disease - Systematic Review and Metanalysis.

INTRODUCTION: Hepatic steatosis is a frequent condition that afflicts, especially, obese and insulin-resistant patients. Diagnosis is usually made through imaging tests. Despite the high prevalence and risk of complications, there is no specific treatment approved, though a vast number of medications have been tested. OBJECTIVE: This study aimed to determine the efficacy of dipeptidyl peptidase IV inhibitors (i DPP- IV) in the treatment of NAFLD. METHODS: We searched the electronic databases of the Cochrane Library, MEDLINE, EMBASE, and LILACS, as well as reference lists of the included studies and grey literature; 9 studies were selected for inclusion. RESULTS: 7 studies were used for metanalysis for 3 outcomes. i DPP-IV showed an ALT-reducing power of MD -10.83 (95% CI 35.23 to 13.57) at 3 months and MD -9.27 (95% CI 10.92 to -7.62) at 6 months of intervention, as well as a reduction of hepatic steatosis via MRI of SMD 0.10 (95% CI 0.31 to 0.50); the overall incidence of adverse events was very low. The studies were considered of low and very low quality by the GRADE evaluation. CONCLUSION: Because of the overall poor quality of the studies and heterogeneity of the population analyzed, i DPP-IV did not show efficacy on inflammatory markers or fibrosis in patients with NAFLD.

Association between obesity and sedentary behavior in adults / Associação entre a obesidade e o comportamento sedentário em adultos

Abstract Although sedentary behavior (SB) is related to the development of metabolic diseases, there is still no consensus in literature about the association between accelerometer-based SB and obesity, especially adjusted for cardiovascular risk factors and level of daily physical activities. The aim was to evaluate the association between obesity and SB adjusted for potential confounders in adults. Data from 780 participants of the Epidemiology and Human Movement (EPIMOV) Study were analyzed. Body weight, body mass index (BMI), and fat body mass as percentage (%FBM) (bioelectrical impedance) were obtained and, then, used to stratify participants. SB was objectively measured using triaxial waist-worn accelerometers placed above the dominant hip during waking hours for at least four consecutive days (4-7 days). SB and its pattern were not significantly different between obesity groups. Although SB presented some significant correlations with obesity, the correlation and determination coefficient indicated weak association between SB and obesity (e.g., BMI and %FBM). Obesity presented little or no association with SB and its pattern after adjustment for potential confounders, especially when SB is measured through accelerometry.

Resumo Embora o comportamento sedentário (CS) esteja relacionado ao desenvolvimento de doenças metabólicas, ainda não há consenso na literatura sobre a associação entre o CS avaliado diretamente por acelerometria e a obesidade, especialmente quando essa relação é ajustada por fatores de risco cardiovascular e nível de atividade física. Objetivou-se avaliar a associação entre CS e obesidade ajustada por potenciais confundidores em adultos. Foram analisados os dados de 780 participantes do Estudo Epidemiológico sobre o Movimento Humano (EPIMOV). Dados relativos à massa corporal, índice de massa corporal (IMC) e porcentagem de gordura corporal (%GC) (bioimpedância elétrica) foram obtidos e, então, utilizados para estratificar os participantes. O CS foi medido objetivamente por meio de acelerômetros triaxiais colocados sob o quadril dominante durante as horas de vigília por, pelo menos, quatro dias consecutivos (4-7 dias). O CS e seu padrão não foram significativamente diferentes entre os grupos de obesidade. Embora o CS tenha apresentado algumas correlações significativas com a obesidade, o coeficiente de correlação e determinação indicou uma fraca associação entre o CS e a obesidade (por exemplo, IMC e %GC). A obesidade apresentou pouca ou nenhuma associação com o CS e seu padrão após o ajuste para potenciais fatores de confusão, principalmente quando avaliado com acelerômetro.

Use of a Smartphone App to Increase Physical Activity Levels in Insufficiently Active Adults: Feasibility Sequential Multiple Assignment Randomized Trial (SMART).

BACKGROUND: The sequential multiple assignment randomized trial (SMART) design allows for changes in the intervention during the trial period. Despite its potential and feasibility for defining the best sequence of interventions, so far, it has not been utilized in a smartphone/gamified intervention for physical activity. OBJECTIVE: We aimed to investigate the feasibility of the SMART design for assessing the effects of a smartphone app intervention to improve physical activity in adults. We also aimed to describe the participants' perception regarding the protocol and the use of the app for physical activity qualitatively. METHODS: We conducted a feasibility 24-week/two-stage SMART in which 18 insufficiently active participants (<10,000 steps/day) were first randomized to group 1 (smartphone app only), group 2 (smartphone app + tailored messages), and a control group (usual routine during the protocol). Participants were motivated to increase their step count by at least 2000 steps/day each week. Based on the 12-week intermediate outcome, responders continued the intervention and nonresponders were rerandomized to subsequent treatment, including a new group 3 (smartphone app + tailored messages + gamification) in which they were instructed to form groups to use several game elements available in the chosen app (Pacer). We considered responders as those with any positive slope in the linear relationship between weeks and steps per day at the end of the first stage of the intervention. We compared the accelerometer-based steps per day before and after the intervention, as well as the slopes of the app-based steps per day between the first and second stages of the intervention. RESULTS: Twelve participants, including five controls, finished the intervention. We identified two responders in group 1. We did not observe relevant changes in the steps per day either throughout the intervention or compared with the control group. However, the rerandomization of five nonresponders led to a change in the slope of the steps per day (median -198 steps/day [IQR -279 to -103] to 20 steps/day [IQR -204 to 145]; P=.08). Finally, in three participants from group 2, we observed an increase in the number of steps per day up to the sixth week, followed by an inflection to baseline values or even lower (ie, a quadratic relationship). The qualitative analysis showed that participants' reports could be classified into the following: (1) difficulty in managing the app and technology or problems with the device, (2) suitable response to the app, and (3) difficulties to achieve the goals. CONCLUSIONS: The SMART design was feasible and changed the behavior of steps per day after rerandomization. Rerandomization should be implemented earlier to take advantage of tailored messages. Additionally, difficulties with technology and realistic and individualized goals should be considered in interventions for physical activity using smartphones. TRIAL REGISTRATION: Brazilian Registry of Clinical Trials RBR-8xtc9c; http://www.ensaiosclinicos.gov.br/rg/RBR-8xtc9c/.

Effects of the juçara fruit supplementation on metabolic parameters in individuals with obesity: a double-blind randomized controlled trial.

Adipose tissue inflammation has been proposed as a central mechanism connecting obesity with its metabolic and vascular complications due to the imbalance in the expression of several hormones and adipokines. Berries rich in polyphenols and unsaturated fatty acids have been able to prevent both obesity and adipose tissue inflammation, improving metabolic functions in human subjects and animal models of obesity. Juçara has been considered a super fruit owing to its nutritional composition and relevant biological activities with an interesting response in animals. Thus, we aimed to verify the potential antiobesogenic effect of juçara supplementation in humans. We conducted a double-blind, placebo-controlled, randomized trial with 35 adults with obesity of both sexes. They were assessed for resting metabolic rate, anthropometry and body composition, blood pressure, metabolic parameters and adipokines. Subsequently, they were randomized into two groups to use or not (placebo) 5 g lyophilized juçara for 6 weeks. Supplementation with juçara was significantly effective in reducing body fat, increasing high-density lipoprotein cholesterol and doubling serum adiponectin. Besides, juçara supplementation, high-density lipoprotein cholesterol and neck circumference were predictors to explain the enhancement in adiponectin. Juçara supplementation was determinant to improve adiponectin levels, and it may be considered a novel strategy for the treatment of obesity-related metabolic diseases.

Dose-response relationship between very vigorous physical activity and cardiovascular health assessed by heart rate variability in adults: Cross-sectional results from the EPIMOV study.

The minimum amount of physical activity needed to obtain health benefits has been widely determined. Unlikely, the impact of extreme amounts of very vigorous physical activity (VVPA, ≥ 8 metabolic equivalents) to the heart remains controversial. We aimed to evaluate the dose-response relationship between VVPA and heart rate variability (HRV) in adults. We selected 1040 asymptomatic individuals (60% women, 42 ± 15 years, 28 ± 6 kg/m2) from the Epidemiology and Human Movement Study (EPIMOV). Participants remained in the supine position for 10 min, and we selected an intermediate 5-min window for HRV analysis. The standard deviation of the RR intervals, root mean square of RR intervals, successive RR intervals that differ > 50 ms, powers of the low-and high-frequency bands and Poincaré plot standard deviations were quantified. Participants used a triaxial accelerometer (Actigraph GT3x+) above the dominant hip for 4-7 consecutive days for quantifying their physical activity. We also evaluated the maximum oxygen uptake ([Formula: see text]) during an exercise test. We stratified participants into five groups according to the VVPA in min/week (group 1, ≤ 1.50; 2, 1.51-3.16; 3, 3.17-3.54; 4, 3.55-20.75; and 5, > 20.75). The linear trends of the HRV through the quintiles of VVPA were investigated. We used logarithmic transformations to compare the five groups adjusted for age, sex, cardiovascular risk, and [Formula: see text]. We found a better HRV with increased VVPA for all HRV indices studied (p trend < 0.05). However, group 5 did not differ from group 4 (p > 0.05) for none of the indices. We conclude that there is an incremental benefit of VVPA on HRV of asymptomatic adults. Since we found neither additional benefits nor the harmful impact of amounts of VVPA as high as 22 min/week on HRV, our results should not discourage asymptomatic adults to perform VVPA.

The association between physical activity, sedentary behavior and the occurrence of falls in asymptomatic adults over 40 years old / Associação entre atividade física, comportamento sedentário e a ocorrência de quedas em adultos assintomáticos acima dos 40 anos de idade / La asociación entre la actividad física, el comportamiento sedentario y la ocurrencia de caídas en adultos asintomáticos mayores de 40 años

Abstract Introduction: Sedentary behavior (SB) has been described as an independent risk factor for health, regardless of the recommended amount of moderate-to-vigorous physical activity (MVPA). However, SB and MVPA as predictors of falls have been poorly investigated. Objective: To compare the associations between SB and MVPA and the occurrence of falls in middle-aged and older adults. Method: The participants wore a triaxial accelerometer over the dominant hip for seven days to measure SB and MVPA. The occurrence of falls and cardiovascular risk factors were assessed by self-report. Isokinetic peak torque (PT) of knee extension, peak oxygen uptake (V'O2) in a ramp treadmill protocol, and lean (LBM) body mass and body fat (BFM) (bioelectrical impedance) were also assessed. The critical roles of SB and MVPA on the occurrence of falls were compared by multiple logistic regression adjusted for age, sex, cardiovascular risk factors, LBM, peak V'O2, and PT of knee extension. Results: 379 participants were evaluated, aged 40-80 years. Forty-eight participants reported at least one fall in the previous 12 months (14.5%). Fallers presented lower SB and higher MVPA. They were predominantly women and older adults with lower physical fitness. After multivariate analysis, MVPA, but not SB, was selected as an independent predictor of falls, increasing the odds ratio of having a fall (1.184, 95% confidence interval, 1.016 - 1.378). Conclusion: Episodes of falls in predominantly middle-aged and women subjects were associated with a higher amount of MVPA, not the opposite, indicating an adverse effect of MVPA in these subjects.

Resumo Introdução: O Comportamento sedentário (CS) tem sido descrito como fator de risco independente para saúde, a despeito da recomendação de atividade física moderada a intensa (AFMI). Contudo, pouco foi investigado se CS e AFMI são preditores da ocorrência de quedas. Objetivo: Comparar as associações entre CS e AFMI e a ocorrência de quedas em adultos de meia-idade e idosos. Método: Os participantes usaram acelerômetro triaxial no quadril dominante por sete dias para obtenção de CS e AFMI. A ocorrência de quedas e o risco cardiovascular foram avaliados através de autorrelato. Avaliamos o pico de torque (PT) isocinético da extensão de joelho, o pico de consumo de oxigênio (V'O2) em protocolo de rampa na esteira, e massa magra (MMC) e gordura (GC) corporais (bioimpedância elétrica). Comparamos o papel de CS e AFMI na ocorrência de quedas através de regressões lineares múltiplas ajustadas por idade, sexo, fatores de risco para doença cardiovascular, MMC, V'O2 pico, e PT da extensão de joelho. Resultados: Avaliamos 379 participantes de 40 - 80 anos. Quarenta e oito participantes reportaram, pelo menos, uma queda nos 12 meses anteriores ao estudo (14.5%). Os caidores apresentaram menor CS e maior AFMI. Eles eram predominantemente mulheres e idosos com menor aptidão física. Após as análises multivariadas, AFMI foi selecionada como preditor independente da ocorrência de quedas, aumentando o odds ratio de cair (1.184, 95% intervalo de confiança, 1.016 - 1.378). Conclusão: Os episódios de quedas, sobretudo em mulheres de meia-idade, foram associados com maior AFMI, indicando efeito adverso da AFMI nestes sujeitos.

Resumen Introducción: El comportamiento sedentario (CS) se ha descrito como un factor de riesgo independiente para la salud, independientemente de la cantidad recomendada de actividad física moderada a vigorosa (AFMV). El CS y el AFMV como predictores de caídas fueron poco investigados. Objetivo: Comparar las asociaciones entre CS y AFMV, y la ocurrencia de caídas en adultos de mediana edad y mayores. Método: Los participantes usaron un acelerómetro triaxial durante siete días para medir CS y AFMV. La ocurrencia de caídas y factores de riesgo cardiovascular se evaluaron mediante autoinforme. Se evaluó el torque máximo isocinético (TM) de la extensión de la rodilla, el consumo máximo de oxígeno (V'O2) en un protocolo de rampa en la estera, y masas corporales magra (MMC) y grasa (GC) (impedancia bioeléctrica). Comparamos los papeles de CS y AFMV en la ocurrencia de caídas mediante la regresión logística múltiple ajustada por edad, sexo, factores de riesgo cardiovascular, MMC, pico de V'O2 y TM de la extensión de la rodilla. Resultados: Se evaluaron 379 participantes de 40 - 80 años. Cuarenta y ocho participantes informaron al menos una caída en los 12 meses previos (14,5%). Caedores presentaron menor CS y mayor AFMV. Eran predominantemente mujeres y mayores con menor aptitud física. Después de los análisis multivariados, AFMV, pero no CS, fue seleccionada como predictor independiente de caídas, lo que aumentó la odds ratio de tener una caída (1.184, intervalo de confianza del 95%, 1,016 - 1,378). Conclusión: los episodios de caídas en mujeres de mediana edad se asociaron con mayor AFMV, lo que indica un efecto adverso de AFMV en estos sujetos.

Reference values for the 6-min walk test in healthy middle-aged and older adults: from the total distance traveled to physiological responses / Valores de referência para o teste de caminhada de 6 minutos em adultos saudáveis de meia-idade e idosos: da distância total percorrida às respostas fisiológicas / Valores de referencia para la prueba de caminata de 6 minutos en adultos sanos de mediana edad y de edad avanzada: de la distancia total a las respuestas fisiológicas

Abstract Introduction: Physiological responses to the 6-min walk test (6MWT) have been increasingly evaluated in patients with cardiopulmonary diseases. However, previous studies did not include healthy persons. Objective: To evaluate the intensity of 6MWT, to develop a series of predictive equations for the physiological variables and to test their reliability in healthy middle-aged and older adults. Method: We evaluated 102 non-trained healthy adults (54 women, aged 61 ± 10 years) and a cross-validation sample of 30 participants. We measured physiological responses to the 6MWT and a cardiopulmonary exercise testing (CPET) on a treadmill. Results: The R2 values for regression analysis adjusted by age, body mass, stature, and sex ranged from 0.25 for heart rate and 0.46 for peak V ˙ O 2 The 6MWT distance and 6MWT peak V ˙ O 2 represented 110 ± 10% and 102 ± 15% of the predicted values, respectively, using our equations. The intensity of 6MWT corresponded to 72 ± 13% of the peak O2 and 78 ± 23% of the peak HR in the CPET. Peak V ˙ O 2 in the CPET was adequately predicted by 6MWT peak V ˙ O 2 (R2 = 0.76) and 6MWD (R2 = 0.54). Conclusion: The 6MWT represents a moderate to high-intensity test in middle-aged and older healthy adults and is valid for assessing maximal aerobic exercise capacity. Physiological responses to the 6MWT may be adequately predicted with a combination of anthropometrics and demographics.

Resumo Introdução: As respostas fisiológicas ao teste de caminhada de 6 minutos (TC6) têm sido cada vez mais avaliadas em pacientes com doenças cardiopulmonares. No entanto, estudos anteriores não incluíram pessoas saudáveis. Objetivo: Avaliar a intensidade do TC6, desenvolver uma série de equações preditivas para as variáveis fisiológicas e testar sua confiabilidade em indivíduos saudáveis de meia-idade e idosos. Método: Avaliamos 102 adultos saudáveis não treinados (54 mulheres, com idade de 61 ± 10 anos) e uma amostra de validação cruzada de 30 participantes. Nós medimos as respostas fisiológicas ao TC6 e ao teste de exercício cardiopulmonar (TECP) em esteira rolante. Resultados: Os valores de R2 para análise de regressão ajustados por idade, massa corporal, estatura e sexo variaram de 0,25 para frequência cardíaca e 0,46 para pico V ˙ O 2 A distância e o V ˙ O 2 no TC6 representou 110 ± 10% e 102 ± 15% dos valores previstos, respectivamente, usando nossas equações. A intensidade do TC6 correspondeu a 72 ± 13% do pico de V ˙ O 2 e 78 ± 23% do pico de frequência cardíaca no TECP. O pico de no TECP foi adequadamente previsto pelo pico de V ˙ O 2 (R2 = 0,76) e pela distância no TC6 (R2 = 0,54). Conclusão: O TC6 representa um teste de intensidade moderada a alta em adultos saudáveis de meia-idade e idosos e é válido para avaliar a capacidade máxima de exercício aeróbico. Respostas fisiológicas ao TC6 podem ser adequadamente previstas com uma combinação de dados antropométricos e demográficos.

Resumen Introducción: Las respuestas fisiológicas a la prueba de caminata de 6 minutos (PC6M) se han evaluado cada vez más en pacientes con enfermedades cardiopulmonares. Sin embargo, estudios anteriores no incluyeron a personas sanas. Objetivo: Evaluar la intensidad de la PC6M, desarrollar una serie de ecuaciones predictivas para las variables fisiológicas y probar su confiabilidad en individuos sanos de mediana edad y en ancianos. Método: Evaluamos 102 adultos sanos no entrenados (54 mujeres, con edad de 61 ± 10 años) y una muestra de validación cruzada de 30 participantes. Medimos las respuestas fisiológicas a la PC6M y a una prueba de ejercicio cardiopulmonar (PECP) en la cinta de correr. Resultados: Los valores de R2 para análisis de regresión ajustados por edad, masa corporal, estatura y sexo variaron de 0,25 para frecuencia cardíaca y 0,46 para pico O2. La distancia y el V ˙ O 2 en la PC6M representaron 110 ± 10% y 102 ± 15% de los valores previstos, respectivamente, usando nuestras ecuaciones. La intensidad de la PC6M correspondió a 72 ± 13% del pico de V ˙ O 2 y a 78 ± 23% del pico de frecuencia cardiaca en la PECP. El pico de V ˙ O 2 en la PECP fue adecuadamente previsto por el pico de V ˙ O 2 (R2 = 0,76) y por la distancia en la PC6M (R2 = 0,54). Conclusión: La PC6M representa una prueba de intensidad moderada a alta en adultos sanos de mediana edad y en ancianos y es válida para evaluar la capacidad máxima de ejercicio aeróbico. Las respuestas fisiológicas a la PC6M pueden ser previstas con una combinación de datos antropométricos y demográficos.

Prevalence of exercise intolerance in obese adults undergoing cardiopulmonary exercise testing / Prevalência de intolerância ao exercício em adultos obesos submetidos ao teste de exercício cardiopulmonar

Abstract We hypothesized that the prevalence of exercise intolerance (EI, peak O2 uptake < 83%pred.) is not significantly affected by body mass index (BMI) in adults undergoing cardiopulmonary exercise testing (CPET). We aimed to evaluate the prevalence of EI and the influence of BMI in asymptomatic adults. The results of 780 adults (age 41 ± 13 years) who underwent CPET were evaluated. Participants were stratified according to BMI: normal weight (n = 227), overweight (n = 198), and obese class 1 (n = 155), 2 (n = 131), and 3 (n = 69). After cardiovascular risk assessment, the participants underwent CPET on a treadmill ramp protocol. The prevalence of EI was 20, 16, 21, 25, and 21% in the stratified groups respectively, and no significant differences were found. Predictors of EI were physical inactivity, age, and smoking. The prevalence of EI in asymptomatic adults is considerable, regardless of BMI. The obesity-related reduction in cardiorespiratory fitness seems to be as clinically relevant as in non-obese counterparts.

Resumo Levantamos a hipótese de que a prevalência de intolerância ao exercício (IE, pico de consumo de O2 < 83%pred.) não é significativamente afetada pelo índice de massa corporal (IMC) em adultos submetidos ao teste de exercício cardiopulmonar (TECP). Nosso objetivo foi avaliar a prevalência de IE e a influência do IMC em adultos assintomáticos. Foram avaliados os resultados do TECP de 780 adultos (idade 41 ± 13 anos). Os participantes foram estratificados de acordo com o IMC: eutrófico (n = 227), sobrepeso (n = 198), e obesidade grau 1 (n = 155), 2 (n = 131), e 3 (n = 69). Após a avaliação do risco cardiovascular, os participantes foram submetidos ao TECP em uma esteira, sob o protocolo de rampa. A prevalência de IE foi 20, 16, 21, 25, e 21% respectivamente nos grupos estratificados, e nenhuma diferença significativa foi encontrada. Os preditores da IE foi inatividade física, idade e tabagismo. A prevalência de IE em adultos assintomáticos é considerável, independentemente do IMC. A redução da aptidão cardiorrespiratória relacionada a obesidade parece ser clinicamente relevante como em não obesos.

A new equation to predict peak VO2 in obese patients during cardiopulmonary exercise testing.

We aimed to develop an equation to predict peak VO2 in obese subjects undergoing CPET. In addition, we evaluated and compared three published equations. We randomized 346 obese subjects undergoing CPET into a group for developing the equation (n = 272) and a group for cross-validation (n = 74), compared through the Bland and Altman method. Height, sex and age were responsible for 85·5% of total variability of the peak VO2. Additional 1% and 0·7% of the variability were, respectively, explained by physical inactivity and diabetes. The equation devised was as follows: peakVO2mlmin-1=-677·8+(2135·9×heightm)+(706·8×sexmales=1;females=0)-(15·5×ageyears)-(161·1×physicalinactivityyes=1;no=0)-(176·3×diabetesyes=1;no=0). The mean difference between the estimated and measured peak VO2 was 7 ml min-1 , with a 23·9% bias. Published equations overestimated the peak VO2 by 35·3%, 49·1% and 46·2% bias. The equation developed in this study performed better in predicting peak VO2 in obese adults improving ramp protocol design and CRF evaluations in obese subjects.

Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study.

BACKGROUND: Insulin resistance (IR) and progressive pancreatic ß-cell dysfunction have been identified as the two fundamental features in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus. We aimed to investigate correlations between anthropometric indices of obesity and IR in non-diabetic obese individuals, and the cutoff value from receiver operating characteristic (ROC) curve analysis. DESIGN AND SETTING: Cross-sectional study conducted in a private clinic. METHODS: We included obese individuals (body mass index, BMI ≥ 30 kg/m2) with no diabetes mellitus (fasting glucose levels ≤ 126 mg/dl). The participants were evaluated for the presence of cardiovascular risk factors and through anthropometric measurements and biochemical tests. Furthermore, IR was assessed indirectly using the homeostatic model assessment (HOMA)-IR and HOMA-ß indexes. The area underthe curve (AUC) of the variables was compared.The sensitivity, specificity and cutoff of each variable for diagnosing IR were calculated. RESULTS: The most promising anthropometric parameters for indicating IR in non-diabetic obese individuals were waist-to-height ratio (WHtR), waist circumference (WC) and BMI. WHtR proved to be an independent predictor of IR, with risk increased by 0.53% in HOMA-IR, 5.3% in HOMA-ß and 1.14% in insulin. For HOMA-IR, WHtR had the highest AUC value (0.98), followed by WC (0.93) and BMI (0.81). For HOMA-ß, WHtR also had the highest AUC value (0.83), followed by WC (0.75) and BMI (0.73).The optimal WHtR cutoff was 0.65 for HOMA-IR and 0.67 for HOMA-ß. CONCLUSION: Among anthropometric obesity indicators, WHtR was most closely associated with occurrences of IR and predicted the onset of diabetes in obese individuals.

Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study

ABSTRACT BACKGROUND: Insulin resistance (IR) and progressive pancreatic β-cell dysfunction have been identified as the two fundamental features in the pathogenesis of obesity and non-insulin-dependent diabetes mellitus. We aimed to investigate correlations between anthropometric indices of obesity and IR in non-diabetic obese individuals, and the cutoff value from receiver operating characteristic (ROC) curve analysis. DESIGN AND SETTING: Cross-sectional study conducted in a private clinic. METHODS: We included obese individuals (body mass index, BMI ≥ 30 kg/m2) with no diabetes mellitus (fasting glucose levels ≤ 126 mg/dl). The participants were evaluated for the presence of cardiovascular risk factors and through anthropometric measurements and biochemical tests. Furthermore, IR was assessed indirectly using the homeostatic model assessment (HOMA)-IR and HOMA-β indexes. The area underthe curve (AUC) of the variables was compared.The sensitivity, specificity and cutoff of each variable for diagnosing IR were calculated. RESULTS: The most promising anthropometric parameters for indicating IR in non-diabetic obese individuals were waist-to-height ratio (WHtR), waist circumference (WC) and BMI. WHtR proved to be an independent predictor of IR, with risk increased by 0.53% in HOMA-IR, 5.3% in HOMA-β and 1.14% in insulin. For HOMA-IR, WHtR had the highest AUC value (0.98), followed by WC (0.93) and BMI (0.81). For HOMA-β, WHtR also had the highest AUC value (0.83), followed by WC (0.75) and BMI (0.73).The optimal WHtR cutoff was 0.65 for HOMA-IR and 0.67 for HOMA-β. CONCLUSION: Among anthropometric obesity indicators, WHtR was most closely associated with occurrences of IR and predicted the onset of diabetes in obese individuals.

Living near the port area is associated with physical inactivity and sedentary behavior.

CONTEXT AND OBJECTIVE:: The impact of the port of Santos, Brazil, on the population's health is unknown. We aimed to evaluate the association between living near the port area and physical inactivity and sedentary behavior. DESIGN AND SETTING:: Cross-sectional study developed at a university laboratory and a diagnostic clinic. METHODS:: 553 healthy adults were selected and their level of physical activity in daily life was assessed using accelerometers. Multiple linear and logistic regressions were performed using physical inactivity and sedentary behavior as the outcomes and living near the port area as the main risk factor, with adjustments for the main confounders. RESULTS:: Among all the participants, 15% were resident near the port area. They took 699 steps/day and presented, weekly, 2.4% more sedentary physical activity, 2.0% less time in standing position and 0.9% more time lying down than residents of other regions. Additionally, living near the port area increased the risk of physical inactivity by 2.50 times and the risk of higher amounts of sedentary behavior (≥ 10 hours/day) by 1.32 times. CONCLUSION:: Living near the port of Santos is associated with physical inactivity and higher sedentary behavior among adults, regardless of confounders. The reasons for this association should be investigated in longitudinal studies.

High sedentary behavior and compromised physical capabilities in adult smokers despite the suitable level of physical activity in daily life / Comportamento sedentário alto e comprometimento da aptidão física em tabagistas adultos apesar do nível adequado de atividade física na vida diária

Abstract Sedentary behavior may play an important role for health outcomes, regardless of the amount of physical activity in daily life (PADL).We aimed to evaluate and compare sedentary behavior as well as physical capabilities in physically active smokers and non-smokers. Twenty-eight adult smokers and 38 non-smokers free of lung disease were matched for age, sex, body mass index, body composition, cardiovascular risk and moderate-to-vigorous PADL. Participants underwent spirometry, cardiopulmonary exercise test (CPET), six-minute walk test (6MWT), isokinetic dynamometry, and body composition (bioelectrical impedance).Despite the similar amount of moderate-to-vigorous PADL(median, 4.5h/week for smokers and 4.0h/week for non-smokers), smokers spent more time lying (median, 8.2h/week: 95% confidence interval, 5.4 to 19.1 vs. 6.1h/week: 3.7 to 11.2) and in sedentary activities (median, 100h/week: 66 to 129 vs. 78h/week: 55 to 122) compared to non-smokers. Smokers also presented worse spirometry, peak V’O2 and maximum heart rate in the CPET, 6MWT, and isokinetic indices (p<0.05). We observed a strong correlation between the time spent lying and spirometry (r = - 0.730) in smokers. Smoking is related to higher sedentary behavior, despite the suitable PADL. An appropriate PADL did not reduce the deleterious effects of smoking on physical capabilities. Interrupting sedentary behavior may be an appropriate intervention target in smokers for reducing the risk of diseases.

Resumo O comportamento sedentário pode desempenhar papel importante nos resultados relacionados à saúde, independentemente da quantidade de atividade física na vida diária (AFVD). Nosso objetivo foi avaliar e comparar o comportamento sedentário, bem como a capacidade funcional em tabagistas e não tabagistas fisicamente ativos. Vinte e oito tabagistas adultos e 38 não tabagistas sem doenças respiratórias foram pareados por idade, sexo, índice de massa corporal, composição corporal, risco cardiovascular e AFVD moderada a intensa. Os participantes realizaram espirometria, teste de exercício cardiopulmonar (TECP), teste de caminhada de seis minutos (TC6), dinamometria isocinética e composição corporal (bioimpedância). Apesar da quantidade semelhante de AFVD moderada a intensa (mediana, 4,5h/semana para tabagistas e 4,0h/semana para os não tabagistas), os tabagistas passaram mais tempo deitados (mediana, 8,2h/semana: intervalo de confiança de 95%, 5,4 a 19,1 vs. 6,1h/semana: 3,7 a 11,2) e em atividades sedentárias (mediana, 100h/semana: 66 a 129 vs. 78h/semana: 55 a 122) em comparação com não tabagistas. Os tabagistas também apresentaram pior espirometria, pico de V’O2 e freqüência cardíaca máxima no TECP, TC6 e índices isocinéticos (p<0,05). Observamos uma forte correlação entre o tempo gasto deitado e a espirometria (r = - 0,730) nos tabagistas. O tabagismo está relacionado ao maior comportamento sedentário, apesar do nível AFVD adequado. Um nível AFVD adequado não reduziu os efeitos deletérios do tabagismo na capacidade funcional. Interromper o comportamento sedentário pode ser uma intervenção apropriada em tabagistas para a prevenção de doenças.

Living near the port area is associated with physical inactivity and sedentary behavior / Morar perto da área portuária está associado à inatividade física e comportamento sedentário

ABSTRACT CONTEXT AND OBJECTIVE: The impact of the port of Santos, Brazil, on the population’s health is unknown. We aimed to evaluate the association between living near the port area and physical inactivity and sedentary behavior. DESIGN AND SETTING: Cross-sectional study developed at a university laboratory and a diagnostic clinic. METHODS: 553 healthy adults were selected and their level of physical activity in daily life was assessed using accelerometers. Multiple linear and logistic regressions were performed using physical inactivity and sedentary behavior as the outcomes and living near the port area as the main risk factor, with adjustments for the main confounders. RESULTS: Among all the participants, 15% were resident near the port area. They took 699 steps/day and presented, weekly, 2.4% more sedentary physical activity, 2.0% less time in standing position and 0.9% more time lying down than residents of other regions. Additionally, living near the port area increased the risk of physical inactivity by 2.50 times and the risk of higher amounts of sedentary behavior (≥ 10 hours/day) by 1.32 times. CONCLUSION: Living near the port of Santos is associated with physical inactivity and higher sedentary behavior among adults, regardless of confounders. The reasons for this association should be investigated in longitudinal studies.

RESUMO CONTEXTO E OBJETIVOS: O impacto do porto de Santos, no Brasil, sobre a saúde da população é desconhecido. Nosso objetivo foi avaliar a associação entre viver nas proximidades da área portuária e a inatividade física e comportamento sedentário. TIPO DE ESTUDO E LOCAL: Estudo transversal desenvolvido em laboratório universitário e em uma clínica de diagnósticos. MÉTODOS: Foram selecionados 553 adultos saudáveis e seu nível de atividade física na vida diária foi avaliado usando acelerômetros. Foi realizada regressão linear múltipla e logística usando a inatividade física e o comportamento sedentário como desfechos e morar perto da área portuária como o fator de risco principal, ajustando para os principais confundidores. RESULTADOS: Entre todos os participantes, 15% residiam na área portuária. Estes deram 699 passos/dia a menos e apresentaram, por semana, 2,4% da atividade física mais sedentária, 2,0% menos tempo em pé e passaram 0,9% mais tempo deitados do que os residentes das demais regiões. Além disso, morar nas proximidades da área portuária aumentou o risco de inatividade física em 2,5 vezes, assim como o risco de maior comportamento sedentário (≥ 10 horas/dia) em 1,32 vezes. CONCLUSÃO: Morar perto do porto de Santos tem associação com a inatividade física, assim como o aumento do comportamento sedentário em adultos, independentemente de fatores de confusão. As razões para tal associação devem ser investigadas em estudos longitudinais.

Use of combined method, accelerometer and international physical activity questionnaire, to determinate occurence of physical inactivity in adults

Abstract Aim Evaluate and compare the proportion of PI and associated factors by IPAQ questionnaire, triaxial accelerometry and the combination of both. Adults aged ( 18 years were enrolled (n = 250). Methods We considered PI as < 600 MET-min/wk in the IPAQ total score, < 150 min/wk of moderate-to-vigorous physical activity in 7 days accelerometry, and the combination of both criteria. Clinical assessment, spirometry, cardiopulmonary exercise test, bioelectrical impedance, isokinetic dynamometry, postural balance, and six-minute walk test were also performed. For participants practicing aquatic, martial arts or cycling, only the IPAQ criterion was considered. Results Proportions of PI were significantly different among methods (IPAQ, 10%; accelerometry, 20%; combination, 25%). After multivariate logistic regressions, PI was determined by age, sex, educational level, risk factors for cardiovascular disease, lean body mass, cardiorespiratory fitness, and postural balance. Conclusion Thus, the combined method for determining PI and associated factors in adults showed great validity, indicating that questionnaires and accelerometers are complementary and should be utilized in combination in epidemiological studies.(AU)