Determination of adhesive rate constant in normal and neoplastic homogeneic cells.

The adhesive rate constant (ARC) of neoplastic SGS-2 cells which have a low contact inhibition, is remarkably higher than that of normal homogeneic fibroblasts. This is in contrast with the mutual adhesion theory which states that the loss of contact inhibition is strictly related to the loss of cell recognition and consequently to the loss of cell adhesion capacity.

[Effect of iodoacetamide on cell-cell adhesion of fibroblasts in the rat]. / Effetto della iodoacetmide sull'adesione cellula-cellula di fibroblasti di ratto.

The -SH groups of rat fibroblasts of cell-coat were blocked with Iodacetamide. This substance interferes negatively on the homologous intercellular adhesion of the tested cells, with a proportional effect related to the concentration used. The meaning of -SH groups on the cell-cell interactions is discussed.