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Eur J Haematol Suppl ; 51: 27-9, 1989.
Article in English | MEDLINE | ID: mdl-2627991

ABSTRACT

Peripheral blood mononuclear cells (PBMC) from 14 patients with multiple myeloma (MM), 3 patients with benign monoclonal gammopathy, 3 patients with Waldenstrom's macroglobulinaemia (WM) and 2 patients with B-cell chronic lymphocytic leukemia (B-CLL) were cultured in vitro in the presence of IL-3 and IL-6. After 3 days, actively proliferating immunoblast-like B cells were apparent in 12/14 cases of MM, 0/3 BMG, 3/3 WM and 0/2 B-CLL. After 6 d, B blasts had evolved into morphologically evident plasma cells expressing the specific monoclonal light and heavy chains. The data indicate that the concerted action of IL-3 and IL-6 synergistically promotes the proliferation and differentiation of circulating plasmacell precursors in malignant monoclonal gammopathies.


Subject(s)
Leukemia, Lymphocytic, Chronic, B-Cell/blood , Neoplastic Cells, Circulating , Paraproteinemias/blood , Cell Differentiation/drug effects , Cell Division/drug effects , Drug Synergism , Humans , Interleukin-3/pharmacology , Interleukin-6/pharmacology , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Neoplastic Cells, Circulating/drug effects , Neoplastic Cells, Circulating/pathology , Neoplastic Stem Cells/drug effects , Paraproteinemias/pathology , Tumor Cells, Cultured/drug effects
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