ABSTRACT
Comparison between 157 children treated with defibrinated convalescent plasma and 257 children treated with specific immunoglobulins revealed the improved effectiveness of the latter treatment in the prevention of chickenpox. Specific Herpes Zoster-Chickenpox immunoglobulins are prepared by caprylic acid fractionation of convalescent plasma. The prevention obtained in more than 90% of cases would appear to be clinically and biologically total as shown by serological surveillance of certain children with particularly severe immune depression.
Subject(s)
Chickenpox/prevention & control , Immunization, Passive/methods , Immunoglobulins/therapeutic use , Child , Convalescence , Herpesvirus 3, Human/immunology , Humans , Immunoglobulins/isolation & purificationSubject(s)
Antibodies, Bacterial/biosynthesis , Antibodies, Viral/biosynthesis , Bacterial Vaccines/pharmacology , Renal Dialysis , Vaccination , Viral Vaccines/pharmacology , Adolescent , Child , Child, Preschool , Diphtheria Toxoid/pharmacology , Humans , Immunity, Cellular , Measles Vaccine/pharmacology , Pertussis Vaccine/pharmacology , Poliovirus Vaccine, Inactivated/pharmacology , Tetanus Toxoid/pharmacologyABSTRACT
Serum antibodies (AB) have been measured before and after vaccination in haemodialysed children. The main finding was a normal increase in AB titres following adsorbed vaccines (diphtheria, tetanus, pertussis and poliomyelitis) demonstrating a normal humoral immune ability. By contrast, a poor response to live attenuated viruses (poliomyelitis and measles) was observed. Two additional findings were an inhibitor effect of tetanus toxoid in mice by uraemic serum, and a constant negative Schick test indicative of suppressed non-specific skin reactivity.
Subject(s)
Antibodies, Bacterial/analysis , Antibodies, Viral/analysis , Renal Dialysis , Uremia/immunology , Vaccination , Adolescent , Child , Child, Preschool , Diphtheria/immunology , Humans , Measles/immunology , Poliomyelitis/immunology , Tetanus/immunology , Uremia/therapy , Whooping Cough/immunologyABSTRACT
Study of 659 cases treated with serum from patients convalescent after herpes zoster and chickenpox over a period of two and a half years in French hospital departments, showed the obvious effectiveness of this type of therapy which seems to be better than that of zoster specific gamma globulin used by other workers since we obtained protection against chickenpox in 90 p. cent of cases, and attenuation of chickenpox in 82 p. cent. It would seem that these results could be improved by increasing the doses used.
