ABSTRACT
BACKGROUND: Despite the high risk of recurrence of congenital malformations, there are no well-accepted preventive measures in developing countries like Tunisia. It is recommended that thorough epidemiological studies of congenital anomalies in this country are needed. The aim of this study is to assess the frequency and types of congenital anomalies in Tunisia and research some risk factors associated with occurrence of these anomalies. METHODS: In this retrospective study, all the fetuses who were autopsied during 21years period from February 1991 to December 2011 (n=9678) at Service of embryofetopathology in the Center of Maternity and Neonatology of Tunis (CMNT) were studied. The classification of malformations was based upon the anatomical system affected. The differences in fetal/maternal characteristics between cases with or without congenital malformations were assessed using Chi2 test. RESULTS: Of the all 9678 autopsied fetuses, 4498 (46.47%) were diagnosed as being malformed fetuses. Anomalies of limbs (22.71%) and digestive and abdominal wall defects (14.76%) were mostly detected, followed by congenital brain defects (13.41%) and nephrourologic abnormalities (11.23%). A marked association of parental consanguinity with increased congenital anomalies rates was found (P<10-6, OR=1.89, CI=1.69-2.13). CONCLUSION: In Tunisia, surveillance and epidemiological evaluation of congenital anomalies underline the high frequency of these events. This will help to better target congenital anomalies prevention and screening policies in our population.
Subject(s)
Congenital Abnormalities/epidemiology , Adolescent , Adult , Autopsy , Congenital Abnormalities/pathology , Consanguinity , Female , Fetus/pathology , Humans , Male , Middle Aged , Retrospective Studies , Risk Factors , Sex Factors , Tunisia/epidemiology , Young AdultABSTRACT
We tried through this study to reassemble the cases of medical termination of pregnancy for foetal or maternal anomalies and analyse the epidemiological characteristics of our population and the procedures of induction of labour. We report a retrospective study about 55 cases of medical termination of pregnancy during 20 months indexed in service "C" of the centre of maternity and neonalogy in collaboration with the service of fetopathology. 12.73% of our patients were older than 38 years. The incidence of medical termination of pregnancy during the same period was about 1.90 cases/100 deliveries. Maternal indications was reported in 34.55% of cases and neurological malformations dominate the foetal anomalies (47.22%). Extra-amniotic saline infusion was used in 52.72% of cases and was responsible of all the complications observed (16.36%).
Subject(s)
Abortion, Induced/statistics & numerical data , Pregnancy Complications , Abortion, Induced/methods , Adult , Age Factors , Congenital Abnormalities , Female , Humans , Middle Aged , Pregnancy , Retrospective Studies , TunisiaABSTRACT
The omphalocele is an average coelosomie, frequency of which is estimated at 1/5000 births. We confront diagnosis antenatal with the exam foetopathologic in purpose of 41 cases of omphalocele brought together over a period going from January 1, 1991 till December, 2000 in the unity of foetopathologie from the CMNT. The frequency of omphaloceles is 4.88% of the children malformed and of 1.64% of the set (group) of the performed an autopsy children. An association malformative was found in 85.4% of cases and a karyotype typical aberration trisomie 13.18 and 21 was identified in 17% of cases. The preview of the children bearers of this deformation is especially bound (connected) to the existence and to the gravity of associated abnormalities. The omphalocele required a multidisciplinary making coverage intervernir obstetriciens, néonatologistes, surgeons pediatre and foetopathologistes.
Subject(s)
Abnormalities, Multiple , Chromosome Aberrations , Hernia, Umbilical/diagnosis , Prenatal Diagnosis , Adult , Autopsy , Female , Hernia, Umbilical/complications , Hernia, Umbilical/pathology , Humans , Incidence , Infant, Newborn , Karyotyping , Male , Pregnancy , Ultrasonography, PrenatalABSTRACT
L'Oligaminos is sometimes discovered during echographic exploration in obstetrics. Etiology is dominated by renal malformations, obstructive myopathies and polymalformatives syndromes therapeutic interruption of pregnancy needs to be discussed in case of bilateral renal malformation.
Subject(s)
Congenital Abnormalities , Oligohydramnios/etiology , Abortion, Therapeutic , Congenital Abnormalities/diagnostic imaging , Female , Humans , Oligohydramnios/diagnostic imaging , Oligohydramnios/therapy , Pregnancy , Prenatal Care/methods , Ultrasonography, PrenatalABSTRACT
Lethal spina bifida continue to be frequent in Tunisia; we report 88 cases of letal spina bifida: 1.05 per thousand births. This pathology was more frequent with women. The up letal spina bifida situated is predominant with female and the dow spina bifida situated is frequent with male. We have noted an association with anencephalia (46 cases) and hydrocephaly (21 cases). Prevention is based on obstetric health care and hygiene dietetic advices to avoid alimentary deficit.
Subject(s)
Spinal Dysraphism/pathology , Adult , Female , Humans , Incidence , Infant , Infant, Newborn , Male , Pregnancy , Prenatal Care , Severity of Illness Index , Sex Factors , Spinal Dysraphism/epidemiology , Tunisia/epidemiologyABSTRACT
So, the epidemiologic study done for 8 years at CMNR Tunis has shown that the incidence is 1.15@1000 births (between 0.52 and 1.66@1000 per year). This anomaly is more frequent in female sex (sex linked = 0.59). The antenatal echographic diagnosis is efficient in 90.5%. This anomaly is more shown at low socio-economic group. The improvement of the socio-economic level and specially the daily uptake of acid folic in periconceptionnel time decrease the frequency of this congenital malformation.
