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Org Biomol Chem ; 20(13): 2715-2728, 2022 03 30.
Article in English | MEDLINE | ID: mdl-35293914

ABSTRACT

A linear sequence to access a novel series of C-nucleosides bearing a quaternary carbon at the anomeric position tethered to a 4-substituted 1,2,3-triazole ring is described. Most of the compounds were obtained from a C-1 alkynyl furanoside, by a tandem or two-step CuAAC/functionalisation sequence, along with a diastereoselective cyanation of the furanoside derivatives in acidic conditions.


Subject(s)
Antiviral Agents , Nucleosides , Antiviral Agents/pharmacology , Triazoles
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