ABSTRACT
OBJECTIVE: This study was undertaken to evaluate the levels of matrix metalloproteinase 2 (MMP-2) in the precursors lesions and in the invasive cervical carcinoma and to quantify the immune reactive expression of MMP-2, using MMP-2 immunohistochemistry, in intraepithelial cervical neoplasias and in the invading cervical carcinoma. STUDY DESIGN: We evaluated 60 samples of cervical tissues using immunohistochemistry for MMP-2 in 5 distinct groups. The groups were divided in control, cervical intraepithelial neoplasia I (CIN I), CIN II, CIN III, and cervical invading carcinoma. RESULTS: MMP-2 expression was found gradually increased according to the degree of cervical intraepithelial neoplasia and cervical carcinoma. (ControlSubject(s)
Biomarkers, Tumor/analysis
, Carcinoma, Squamous Cell/pathology
, Cell Transformation, Neoplastic/pathology
, Matrix Metalloproteinase 2/analysis
, Uterine Cervical Dysplasia/pathology
, Uterine Cervical Neoplasms/pathology
, Adult
, Aged
, Carcinoma, Squamous Cell/metabolism
, Case-Control Studies
, Cervix Uteri/pathology
, Culture Techniques
, Female
, Humans
, Immunohistochemistry
, Middle Aged
, Prognosis
, Reference Values
, Sampling Studies
, Sensitivity and Specificity
, Uterine Cervical Dysplasia/metabolism