ABSTRACT
Reactive oxygen species derived from abdominal fat and uncontrolled glucose metabolism are contributing factors to both oxidative stress and the development of metabolic syndrome (MetS). This study was designed to evaluate the effects of daily administration of an oral glycine supplement on antioxidant enzymes and lipid peroxidation in MetS patients. The study included 60 volunteers: 30 individuals that were supplemented with glycine (15 g/day) and 30 that were given a placebo for 3 months. We analysed thiobarbituric acid reactive substances (TBARS) and S-nitrosohemoglobin (SNO-Hb) in plasma; the enzymatic activities of glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) in erythrocytes; and the expression of CAT, GPX, and SOD2 in leukocytes. Individuals treated with glycine showed a 25% decrease in TBARS compared with the placebo-treated group. Furthermore, there was a 20% reduction in SOD-specific activity in the glycine-treated group, which correlated with SOD2 expression. G6PD activity and SNO-Hb levels increased in the glycine-treated male group. Systolic blood pressure (SBP) also showed a significant decrease in the glycine-treated men (p = 0.043). Glycine plays an important role in balancing the redox reactions in the human body, thus protecting against oxidative damage in MetS patients.
Subject(s)
Antioxidants/administration & dosage , Blood Pressure/drug effects , Dietary Supplements , Glycine/administration & dosage , Metabolic Syndrome/drug therapy , Oxidative Stress/drug effects , Administration, Oral , Adult , Biomarkers/blood , Catalase/blood , Double-Blind Method , Female , Glucosephosphate Dehydrogenase/blood , Glutathione Peroxidase/blood , Hemoglobins/metabolism , Humans , Lipid Peroxidation/drug effects , Male , Metabolic Syndrome/blood , Metabolic Syndrome/diagnosis , Metabolic Syndrome/physiopathology , Mexico , Middle Aged , Superoxide Dismutase/blood , Systole , Thiobarbituric Acid Reactive Substances/metabolism , Time Factors , Treatment OutcomeABSTRACT
Se revisan conceptos de infertilidad vs esterilidad, particularmente los fenómenos involucrados en la regulación de la función ovárica. Se describe la participación de grupos como hormonas esteroides y peptídicas, prostaglandinas y neurotransmisores, así como, la interrelación con la sbase funcionales de los aspectos reproductivos. Se relatan algunas de las patologías endocrinas asociadas frecuentemente a esterilidad tales como síndrome anovulatorio crónico, hiperplasia endometrial, ovarios poliquísticos, hirsutismo, hiperprolactinemia e insuficiencia lútea. En cada uno de estos conceptos se vierte tanto la patología esencial, como el pensamiento de como poder abordar lo intrínseco de cada uno de estos problemas vistos cotidianamente en la clínica de infertilidad
