ABSTRACT
Los linfomas T nasals constituyen un tipo de síndrome linfoproliferativo muy infrecuente. Uno de los problemas fundamentales que presenta para aportar una alta probabilidad de supervivencia a quien lo padece, es la dificultad que presenta para poder llevar a un precoz diagnóstico. Esto es debido a que origina unas lesiones histológicas inespecíficas, así como su clínica. Únicamente la estrecha cooperación entre el otorrinolaringólogo y el anatomopatologo, piuede llegar a obtener un diagnóstico con la mayor celeridad, y por tanto, poder tratarlo de forma correcta; ya que están apareciendo tratamientos novedosos a los que este tipo de enfermedad cada vez están respondiendo mejor. Se presentan los casos de linfomas T nasales diagnosticados en el Servicio de ORL del área sanitaria de Toledo, en un período de 15 años, su sintomatología, tratamiento, evolución y supervivencia. Además de una revisión bibliográfica actualizada sobre este controvertido síndrome
Nasal T lymphoma constitute a type of lymphoproliferative very infrequent symdrome. One of the fondamental problems it presents to bring a high probability of survival obtain a precocious diagnose. It is due that it originates inespecific histologic lesions, and to its clinic. Only the close cooperation between the otorhinolaryngologist and the anatomopathologist can arrive to obtain a very speedy diagnose and in that way the possibility of a correct treatment, because newly treatments appear, to which this type of disease every day better respond. We present the cases of nasal T lymphomas diagnosticated in the ORL Service of the Toledo area during 15 years, their symptomotology, treatment, evolution and survival. Besides a up to date bibliographic revision on this controversial syndrome
Subject(s)
Humans , Adult , Male , Nose Neoplasms/diagnosis , Nose Neoplasms/mortality , Nose Neoplasms/therapy , Lymphoma, T-Cell/diagnosis , Lymphoma, T-Cell/mortality , Lymphoma, T-Cell/therapy , Disease-Free Survival , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Nose Neoplasms/drug therapy , Nose Neoplasms/pathology , Nose Neoplasms , Magnetic Resonance Imaging , Time Factors , Lymphoproliferative Disorders/pathologyABSTRACT
En este trabajo hemos estudiado la expresión inmunohistoquímica de la proteína bcl-2 en 195 pacientes con cáncer de laringe que fueron diagnosticados, tratados y seguidos durante 5 años en el servicio ORL del Hospital Virgen de la Salud (Toledo). En los casos que presentaron metástasis ganglionares analizamos también la expresión de bcl-2 a dicho nivel. Además se ha estudiado el valor pronóstico de la expresión de bcl-2 en este tipo de tumores (desarrollo de recidivas, mortalidad por cáncer de laringe y supervivencia) y analizamod la posible relación de dicha expresión con otros parámetros clínicopatológicos
In this paper we carried out an immunohistochemical study of protein p21WAF1 (EA 10) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain). In the cases with lymph node metastasis; we also studied p21WAF1 expression at this level. Furthermore we have analysed the value of protein p21WAF1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival (and we evaluate the relationship between p21WAF1 expression and other clinic and pathologic parameters. Keywords: p21WAFl Protein. Larynx cancerIn this paper we carried out an immunohistochemical study of bcl-2 protein expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo. Spain). In the cases with lymphonode metastasis we also analysed bcl-2 protein expression at this level. Furthermore we have studied the value of bcl-2 protein expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we analysed the relationship between bcl-2 protein expression and other clinic and pathologic parametersIn this paper we carried out an immunohistochemical study of protein Rb (G3-245) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph node metastasis we also studied Rb expression at this level. Furthermore we have analysed the value of Rb expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between Rb expression and other clinic and pathologic parameters