ABSTRACT
The crosstalk between the colon mucosa and the microbiota represents a complex and delicate equilibrium. Gastrointestinal diseases such as inflammatory bowel disease and colorectal cancer (CRC) are associated with a state of altered microbiota composition known as dysbiosis, which seems to play a causative role in some of these illnesses. Recent reports have shown that the colorectal microbiome is responsible for the response and safety to treatments against CRC, especially immunotherapy, hence opening the possibility to use bacteria as a predictive marker and also as a therapeutic agent. The review objective is to summarize updated reports about the the implication of the colorectal microbiome in the development of CRC, in treatment response and its potential as a therapeutic approach.
Subject(s)
Antineoplastic Agents/therapeutic use , Colon/microbiology , Colorectal Neoplasms/drug therapy , Colorectal Neoplasms/microbiology , Gastrointestinal Microbiome/drug effects , Microbiota/physiology , Animals , Colon/drug effects , Dysbiosis/drug therapy , Dysbiosis/microbiology , Humans , Inflammatory Bowel Diseases/drug therapy , Inflammatory Bowel Diseases/microbiology , Microbiota/drug effectsABSTRACT
No disponible
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Humans , Female , Aged , Aortitis/microbiology , Salmonella enteritidis/pathogenicity , Salmonella Infections/diagnosis , Diagnosis, DifferentialABSTRACT
No disponible
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Humans , Adult , Bacteremia/epidemiology , Streptococcus pneumoniae/pathogenicity , Pneumonia, Pneumococcal/epidemiology , Pneumococcal Infections/epidemiology , Respiratory Tract Infections/microbiology , Drug Resistance, MicrobialSubject(s)
Aorta, Thoracic/microbiology , Aortitis/etiology , Early Diagnosis , Salmonella Infections/etiology , Salmonella enteritidis/isolation & purification , Aged , Aorta, Thoracic/diagnostic imaging , Aortitis/diagnosis , Aortitis/microbiology , Diagnosis, Differential , Female , Humans , Imaging, Three-Dimensional , Salmonella Infections/diagnosis , Salmonella Infections/microbiology , Tomography, X-Ray ComputedSubject(s)
Bacteremia/epidemiology , Pneumonia, Pneumococcal/epidemiology , Streptococcus pneumoniae , Adolescent , Adult , Bacteremia/microbiology , Drug Resistance, Bacterial , Female , Humans , Incidence , Male , Pneumococcal Vaccines/immunology , Pneumococcal Vaccines/therapeutic use , Pneumonia, Pneumococcal/microbiology , Sex Distribution , Spain/epidemiology , Streptococcus pneumoniae/drug effectsABSTRACT
No disponible
Subject(s)
Humans , Male , Infant, Newborn , Length of Stay , Picornaviridae Infections/cerebrospinal fluid , Picornaviridae Infections/diagnosis , Picornaviridae Infections/drug therapy , Parechovirus , Parechovirus/isolation & purificationABSTRACT
BACKGROUND: Members of the genus Pseudonocardia have been widely reported and recovered from several ecosystems, such as soil samples and plant samples. Pseudonocardia bacteria colonize the microbial communities on the integument of fungus gardening ant species. We present the first documented case of Pseudonocardia carboxydivorans isolated in human cerebrospinal fluid (CSF). To the best of our knowledge, this is the first report of an human infection by P. carboxydivorans. CASE PRESENTATION: A patient, who suffered a traumatic brain injury a month before, was admitted to this hospital due to gait alteration and cognitive disturbances. Culture of cerebrospinal fluid showed ramified, not acid-fast, Gram positive bacilli. The bacterium was identified by molecular methods as P. carboxydivorans. CONCLUSION: This is the first documented case of isolating P. carboxydivorans in human CSF in a case of probable meningitis. Further research is needed in order to determine its pathogenic role in human infections.
Subject(s)
Actinobacteria/isolation & purification , Brain Injuries, Traumatic/complications , Gram-Positive Bacterial Infections/cerebrospinal fluid , Actinobacteria/genetics , Actinobacteria/pathogenicity , Aged , Brain Injuries, Traumatic/microbiology , Cerebrospinal Fluid/microbiology , Gram-Positive Bacterial Infections/drug therapy , Gram-Positive Bacterial Infections/etiology , Gram-Positive Bacterial Infections/microbiology , Humans , MaleABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Gordonia Bacterium , Gordonia Bacterium/isolation & purification , Abscess/complications , Abscess/diagnosis , Abscess/drug therapy , Amoxicillin-Potassium Clavulanate Combination/therapeutic use , Agar/analysis , Anti-Infective Agents/therapeutic use , Sputum/cytology , Sputum/microbiologyABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Streptococcus pyogenes/isolation & purification , Streptococcus pyogenes/pathogenicity , Soft Tissue Infections/microbiology , Community-Acquired Infections/microbiology , Soft Tissue Infections/epidemiology , Soft Tissue Infections/metabolism , Soft Tissue Infections/prevention & control , Community-Acquired Infections/epidemiology , Community-Acquired Infections/prevention & controlSubject(s)
Soft Tissue Infections , Streptococcal Infections , Streptococcus pyogenes , Aged , Aged, 80 and over , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Community-Acquired Infections/drug therapy , Community-Acquired Infections/epidemiology , Female , Humans , Incidence , Male , Middle Aged , Soft Tissue Infections/drug therapy , Soft Tissue Infections/epidemiology , Spain , Streptococcal Infections/drug therapy , Streptococcal Infections/epidemiology , Streptococcus pyogenes/drug effectsABSTRACT
Fundamento y objetivo: Describir un cuadro clínico poco habitual como es la meningitis puerperal por Streptococcus agalactiae (S. agalactiae). Paciente y método: Presentamos una meningitis puerperal por S. agalactiae, una rara forma de infección en una puérpera sana y con una presentación atípica. Resultados: Se expone ampliamente el caso clínico, así como los procedimientos realizados en el diagnóstico diferencial y su tratamiento. Se compara con los casos de meningitis publicados en la bibliografía, y como en estos, se realiza un diagnóstico precoz y un inicio rápido del tratamiento antibiótico. Conclusión: La meningitis por S. agalactiae es un proceso infrecuente en el período puerperal, que requiere de un diagnóstico y tratamiento precoces, de los cuales dependerá el pronóstico de la paciente (AU)
Background and objective: To describe an unusual clinical presentation of puerperal meningitis by Streptococcus agalactiae (S. agalactiae). Patient and method: We report a case of puerperal meningitis for S. agalactiae, a rare form of infection in a healthy puerperal and with an atypical presentation. Results: We deeply report the clinical case, the procedures performed to exclude other diseases and management differences. It is compared with meningitis cases reported in the literature, and as in these, we opt for and early diagnosis and a rapid onset of antibiotic treatment. Conclusion: Meningitis caused by S. agalactiae is not a frequent complication in the postpartum period, that requires early diagnosis and treatment of which depends the patient's prognosis AU)
Subject(s)
Humans , Female , Streptococcal Infections/diagnosis , Meningitis, Bacterial/diagnosis , Streptococcus agalactiae/pathogenicity , Postpartum Period , Anti-Bacterial Agents/therapeutic useABSTRACT
BACKGROUND AND OBJECTIVE: To describe an unusual clinical presentation of puerperal meningitis by Streptococcus agalactiae (S. agalactiae). PATIENT AND METHOD: We report a case of puerperal meningitis for S. agalactiae, a rare form of infection in a healthy puerperal and with an atypical presentation. RESULTS: We deeply report the clinical case, the procedures performed to exclude other diseases and management differences. It is compared with meningitis cases reported in the literature, and as in these, we opt for and early diagnosis and a rapid onset of antibiotic treatment. CONCLUSION: Meningitis caused by S. agalactiae is not a frequent complication in the postpartum period, that requires early diagnosis and treatment of which depends the patient's prognosis.
