[Replacement of bone defects with a polyurethane composition with hydroxyapatite high-filling ]. / Zameshchenie kostnykh defektov poliuretanovoi kompozitsiei s vysokim napoleniem gidroksiapatitom.

There have been obtained high-filling polyurethane compositions with hydroxyapatite. Compositions with hydroxyapatite and immunomodulator in the polyurethane base acquire better adhesiveness and improved strength characteristics as evidenced by physical-and-clinical studies made. Modal operations are developed in test animals on bone defects replacing that carry a high mechanical load. Histological studies showed that polyuretane-base high-filling polymeric compositions replace the loss of bone fully, stimulate the processes of bone formation, with no negative responses of the osseous tissue noted.

[Regeneration of the liver by using modified polymer compounds for the purpose of hemostasis]. / Regeneratsiia pecheni pri primenenii s tsel'iu gemostaza modifitsirovannykh polimernykh kompozitsii.

Results of experimental investigations of using polymer compositions KL-3, including modifications with ionol ("Adgenol") and levamisol in 18 rabbits with injuries of the liver are presented. It has been established that 3 and 6 months after using the mentioned compositions viable healing of liver wounds are obtained. Different degrees of intensity of inflammatory reactions and of development of the connective tissue were noted, most pronounced after using "Adgenol". Adding Levamizol to the polymer composition facilitated the recovery of the initial hepatic cells.

[Biocompatibility of microsurgical suture material modified with element-organic compounds]. / Biosovmestimost mikrokhirurgicheskogo shovnogo materiala, modifitsirovannogo elementoorganicheskimi soedineniiami.

By the method of tissue culture, it is established that the capron threads stained by brilliant green, coated with the chemosorbed substances on the base of titanium alkoxides, polyalkylhydridsiloxanes and polyorganilsiloxanes have no histotoxic properties and can be used in microsurgical practice.

[Method for the quantitative study of the growth of fibroblastic cells in tissue culture]. / Metod kolichestvennogo issledovaniia rosta fibroblasticheskikh kletok v kul'ture tkani.

The method is elaborated for a quantitative evaluation of hypodermic fibroblast element growth in tissue culture of albino rats. The method is based on determination of the growth activity and intensity for each of the explant growth zones (compact, necwork-like zones and zone of migrating elements). The method permits a rapid and an exact evaluation of the influence of different substances added to the culture medium.

[Growth of rat fibroblasts in tissue culture as affected by trypsin immobilized on polyurethane substrates]. / Vliianie tripsina, immobilizovannogo na poliuretanovykh podlozhkakh, na rost fibroblastov krysy v kul'ture tkanei.

The growth of fibroblasts of the rat subcutaneous tissue was studied as affected by different doses of trypsin, free and bound, on polyurethane substrates. The method of tissue culture provides essential criteria for estimating the degree of bioincompatibility of polymeric alloimplants in particular when immobilizing biologically active substances on them. Trypsin adsorbed on the polyurethane substrate diffusing gradually into the culture medium is established to inhibit the cell growth. Chemically bounded trypsin in the composition of the polymeric matrix at the early stages of cultivation stimulates for a long time the division of fibroblastic elements and further accelerates their degeneration. It is shown that on polymeric substrates containing no trypsin, the growth character and dynamics of the fibroblastic elements are similar on the whole to these indices for cultures grown in the plasm clot without the substrate.