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1.
J Spinal Cord Med ; : 1-10, 2023 Sep 28.
Article in English | MEDLINE | ID: mdl-37769141

ABSTRACT

CONTEXT: In people with spinal cord injury (SCI), infections are a leading cause of death, and there is a high prevalence of diabetes mellitus, obesity, and hypertension, which are all comorbidities associated with worse outcomes after COVID-19 infection. OBJECTIVE: To characterize self-reported health impacts of COVID-19 on people with SCI related to exposure to virus, diagnosis, symptoms, complications of infection, and vaccination. METHODS: The Spinal Cord Injury COVID-19 Pandemic Experience Survey (SCI-CPES) study was administered to ask people with SCI about their health and other experiences during the COVID-19 pandemic. RESULTS: 223 community-living people with SCI (male = 71%; age = 52±15 years [mean±SD]; paraplegia = 55%) completed the SCI-CPES. Comorbidities first identified in the general population as associated with poor outcomes after COVID-19 infection were commonly reported in this SCI sample: hypertension (30%) and diabetes (13%). 23.5% of respondents reported a known infection exposure from someone who visited (13.5%) or lived in their home (10%). During the study, which included a timeframe when testing was either unavailable or scarce, 61% of respondents were tested for COVID-19; 14% tested or were presumed positive. Fever, fatigue, and chills were the most common symptoms reported. Of the 152 respondents surveyed after COVID-19 vaccines became available, 82% reported being vaccinated. Race and age were significantly associated with positive vaccination status: most (78%) individuals who were vaccinated identified as Non-Hispanic White and were older than those who reported being unvaccinated (57±14 vs. 43±13 years, mean±SD). CONCLUSIONS: Self-reported COVID-19 symptoms were relatively uncommon and not severe in this sample of people with SCI. Potential confounders and limitations include responder, recruitment and self-reporting biases and changing pandemic conditions. Future studies on this topic should query social distancing and other behavioral strategies. Large retrospective chart review studies may provide additional data on incidence and prevalence of COVID-19 infections, symptoms, and severities in the SCI population.

2.
Adv Skin Wound Care ; 36(10): 534-539, 2023 Oct 01.
Article in English | MEDLINE | ID: mdl-37729163

ABSTRACT

OBJECTIVE: To identify genetic biomarkers predisposing individuals with spinal cord injury (SCI) to recurrent pressure injuries (PIs). METHODS: Repeated measures of the transcriptome profile of veterans with SCI at three Veterans Spinal Cord Injuries and Disorders Centers. Exclusion criteria included having significant active systemic disease at time of enrollment. Researchers obtained comprehensive profiles of clinical and health factors and demographic information relevant to PI history at enrollment and at each follow-up visit by reviewing patients' medical charts. Whole blood samples were collected at 6- to 12-month intervals for 2 to 4 years. In addition to DNA profiling with whole genome sequencing of the patients, RNA sequencing was performed to assess pathways associated with PI risk. RESULTS: Whole genome sequencing analysis identified 260 genes that showed increased prevalence of single-nucleotide variations in exonic regions with high (>20) combined annotation-dependent depletion scores between persons with high versus low intramuscular adipose tissue levels when cross-referenced with persons who had recurrent PIs. Gene set enrichment analysis using Hallmark and KEGG (Kyoto Encyclopedia of Genes and Genomes) gene sets of these candidate genes revealed enrichment in genes encoding proteins involved in fatty acid metabolism (P < .01). Further, RNA sequencing revealed upregulated activity in biological senescence pathways and downregulated activity in antimicrobial protection pathways. CONCLUSIONS: Genomic biomarkers may complement electronic health records to support management of complex interactive health issues such as risk of recurrent PIs in people with SCI. These findings may also be leveraged for homogeneous phenotypic grouping of higher-risk individuals.


Subject(s)
Crush Injuries , Pressure Ulcer , Humans , Pressure Ulcer/genetics , Adipose Tissue , Biomarkers , Genomics
3.
J Spinal Cord Med ; : 1-9, 2023 Aug 03.
Article in English | MEDLINE | ID: mdl-37534908

ABSTRACT

CONTEXT: Early during the COVID-19 pandemic, rehabilitation providers received reports from people with spinal cord injury (SCI) of considerable disruptions in caregiver services, medical and nursing care, and access to equipment and supplies; concomitantly, the medical community raised concerns related to the elevated risk of acquiring the infection due to SCI-specific medical conditions. Due to the novel nature of the pandemic, few tools existed to systematically investigate the outcomes and needs of people with SCI during this emergency. OBJECTIVE: To develop a multidimensional assessment tool for surveying the experience of the COVID-19 pandemic on physical and psychological health, employment, caregiving services, medical supplies and equipment, and the delivery of medical care for people with SCI. METHODS: The Spinal Cord Injury COVID-19 Pandemic Experience Survey (SCI-CPES) study, conducted between July 2020 through August 2021, surveyed people with SCI about their experiences during the early COVID-19 pandemic. The SCI-CPES was developed by a SCI care and research consortium using an iterative process. RESULTS: Two hundred and twenty-three people completed the survey. Most respondents resided in the consortium catchment area. As the survey progressed, online informed consent became available allowing dissemination of the SCI-CPES nationally. CONCLUSIONS: The consortium rapidly implemented the capture of experiences with COVID-19 pandemic directly from people with SCI, including survey creation, institutional approvals, distribution, online e-consenting, and data collection. In the future, the SCI-CPES is adaptable for use in other types of emergencies and disasters.

4.
J Spinal Cord Med ; 45(5): 668-680, 2022 09.
Article in English | MEDLINE | ID: mdl-33465012

ABSTRACT

OBJECTIVE: To describe the clinical features and disease course of COVID-19 in veterans with spinal cord injury (SCI). DESIGN: Case series of consecutive veterans with SCI treated at a single center. SETTING: SCI Unit at an urban Veterans Administration hospital at the epicenter of the COVID-19 pandemic in the US. PARTICIPANTS: Seven SCI veterans with confirmed COVID-19 infection by PCR; all veterans were male, mean age was 60.6. Five had cervical level of injury, and five had complete injury (AIS A). Six veterans had a BMI > 22; three had chronic obstructive pulmonary disease; three had chronic kidney disease. INTERVENTIONS: None. OUTCOME MEASURES: Presence of co-morbidities, diagnostic values, and clinical findings. RESULTS: Each case presented differently; the most common presenting sign was fever. In the three individuals with critical and fatal infection, pre-existing comorbidities were more common and inflammatory markers were markedly elevated. CONCLUSION: Level and completeness of SCI did not appear to correlate with COVID-19 severity, as mild and asymptomatic illness was noted in persons with high grade SCI. As has been shown to be the case in the general population, pre-existing comorbidities are the most reliable predictors of severe SARS-CoV-2 infection currently available for persons with chronic SCI. Contrary to concerns that SCI may mask the cardinal signs of COVID-19, such as fever and cough, by way of compromised thermoregulation and thoracoabdominal musculature, such signs were common in our series. To facilitate early detection, prompt treatment, and minimized viral spread, the implementation of preventive strategies by SCI units is recommended.


Subject(s)
COVID-19 , Spinal Cord Injuries , Veterans , COVID-19/epidemiology , Female , Hospitals, Veterans , Humans , Male , Middle Aged , Pandemics , SARS-CoV-2 , Spinal Cord Injuries/complications , Spinal Cord Injuries/epidemiology , United States , United States Department of Veterans Affairs
6.
Am J Infect Control ; 49(6): 775-783, 2021 06.
Article in English | MEDLINE | ID: mdl-33359552

ABSTRACT

BACKGROUND: Daily use of chlorhexidine gluconate (CHG) has been shown to reduce risk of healthcare-associated infections. We aimed to assess moving CHG bathing into routine practice using a human factors approach. We evaluated implementation in non-intensive care unit (ICU) settings in the Veterans Health Administration. METHODS: Our multiple case study approach included non-ICU units from 4 Veterans Health Administration settings. Guided by the Systems Engineering Initiative for Patient Safety, we conducted focus groups and interviews to capture barriers and facilitators to daily CHG bathing. We measured compliance using observations and skin CHG concentrations. RESULTS: Barriers to daily CHG include time, concern of increasing antibiotic resistance, workflow and product concerns. Facilitators include engagement of champions and unit shared responsibility. We found shortfalls in patient education, hand hygiene and CHG use on tubes and drains. CHG skin concentration levels were highest among patients from spinal cord injury units. These units applied antiseptic using 2% CHG impregnated wipes vs 4% CHG solution/soap. DISCUSSION: Non-ICUs implementing CHG bathing must consider human factors and work system barriers to ensure uptake and sustained practice change. CONCLUSIONS: Well-planned rollouts and a unit culture promoting shared responsibility are key to compliance with daily CHG bathing. Successful implementation requires attention to staff education and measurement of compliance.


Subject(s)
Anti-Infective Agents, Local , Cross Infection , Baths , Chlorhexidine/analogs & derivatives , Cross Infection/prevention & control , Ergonomics , Humans , Intensive Care Units
7.
Am J Hypertens ; 32(10): 938-944, 2019 09 24.
Article in English | MEDLINE | ID: mdl-31125393

ABSTRACT

BACKGROUND: To determine the degree of blood pressure instability over a 30-day home observation in participants with spinal cord injury grouped by level of injury pertaining to cardiovascular autonomic regulation. METHODS: This is an observational study completed at the Kessler Foundation and James J. Peters Veterans Medical Center. Seventy-two participants with tetraplegia (C1-T1), 13 with high thoracic (T2-T4), and 28 with low thoracic (T5-T12) injury participated in this study. Participants were asked to record their blood pressure using an ambulatory blood pressure monitor three times a day for 30 days. RESULTS: The number of blood pressure fluctuations was significantly increased in the tetraplegia group compared with the paraplegia groups. Age and duration of injury contributed to an increase in the observation of 30-day blood pressure instability; however, completeness of injury did not. CONCLUSION: The data indicate significant blood pressure instability that may not be exclusive to persons with tetraplegia; in fact, individuals with low thoracic injuries demonstrated severe blood pressure fluctuations. The use of a monitor at home for an extended period may help document dangerous and extreme fluctuations in blood pressure and should be considered an important adjunctive clinical practice for tracking of the secondary consequences in the spinal cord injury population.


Subject(s)
Blood Pressure Monitoring, Ambulatory , Blood Pressure , Hypertension/diagnosis , Hypotension/diagnosis , Paraplegia/diagnosis , Quadriplegia/diagnosis , Spinal Cord Injuries/diagnosis , Thoracic Vertebrae/injuries , Adult , Aged , Aged, 80 and over , Female , Humans , Hypertension/etiology , Hypertension/physiopathology , Hypotension/etiology , Hypotension/physiopathology , Injury Severity Score , Male , Middle Aged , Paraplegia/etiology , Paraplegia/physiopathology , Predictive Value of Tests , Quadriplegia/etiology , Quadriplegia/physiopathology , Spinal Cord Injuries/complications , Spinal Cord Injuries/physiopathology , Thoracic Vertebrae/physiopathology , Time Factors , Young Adult
8.
Phys Med Rehabil Clin N Am ; 30(2): 473-483, 2019 05.
Article in English | MEDLINE | ID: mdl-30954160

ABSTRACT

Telerehabilitation refers to the virtual delivery of rehabilitation services into the patient's home. This methodology has shown to be advantageous when used to enhance or replace conventional therapy to overcome geographic, physical, and cognitive barriers. The exponential growth of technology has led to the development of new applications that enable health care providers to monitor, educate, treat, and support patients in their own environment. Best practices and well-designed Telerehabilitation studies are needed to build and sustain a strong Telerehabilitation system that is integrated in the current health care structure and is cost-effective.


Subject(s)
Telerehabilitation , Humans , Neurological Rehabilitation/economics , Neurological Rehabilitation/methods , Telerehabilitation/economics , Telerehabilitation/methods
9.
Lipids Health Dis ; 14: 81, 2015 Jul 28.
Article in English | MEDLINE | ID: mdl-26215870

ABSTRACT

BACKGROUND: Persons with spinal cord injury (SCI) often have low levels of physical activity, which predispose to increased adiposity and decreased high density lipoprotein cholesterol (HDL-C) concentrations, and, generally, normal low density lipoprotein cholesterol (LDL-C) concentrations. In spite of the mixed lipoprotein profile, the SCI population has been reported to have an elevated risk of cardiovascular-related morbidity and mortality. Nuclear magnetic resonance spectroscopy may permit a more precise quantification of lipoprotein particle (P) species, enabling a more accurate inference of risk for cardiovascular disease (CVD) in the SCI population. METHODS: Fasting blood samples were obtained on 83 persons with chronic SCI and 62 able-bodied (AB) subjects. Fasting plasma insulin (FPI), triglycerides (TG), and P number and size of VLDL (very low density lipoprotein), LDL, and HDL subclasses were determined. AB and SCI subjects were stratified based on HDL-C (i.e., Low <40 and Normal ≥ 40 mg/dl): AB-Normal (n = 48), AB-Low (n = 14), SCI-Normal (n = 49), and SCI-Low (n = 34). Factorial analyses of variance were performed to identify group differences in lipoprotein measurements. Pearson correlations were performed between the number of P by lipoprotein subclass, size, FPI, and TG. RESULTS: The SCI-Normal group was not significantly different from the AB-Normal group for body composition, FPI, TG or LP-IR and had negligible differences in the lipoprotein P profile, except for fewer number and smaller size of HDL-P. The SCI-Low group had a similar lipoprotein profile to that of the AB-Low group, but with a lipid P composition associated with a heightened atherogenic risk and greater tendency toward insulin resistance by the Lipoprotein-Insulin Resistance (LP-IR) score. In the SCI-Low group, the decreased number and reduced size of lipoprotein P were more prevalent and may be associated with increased waist circumference (i.e., abdominal adiposity), relatively elevated TG values (compared to the other subgroups), and an underlying subclinical state of insulin resistance. CONCLUSIONS: Prolonged sitting and restricted physical activity in individuals with SCI had the most profound effect on the HDL-C and its lipoprotein P subclasses, but not on LDL-C, however its P subclasses were also unfavorably affected but not to the same degree. The quantification of lipoprotein P characteristics may be a potent tool for the determination of risk for CVD in persons with SCI.


Subject(s)
Lipoproteins/blood , Models, Biological , Motor Activity , Posture , Spinal Cord Injuries/blood , Spinal Cord Injuries/physiopathology , Adult , Cholesterol, HDL/blood , Cohort Studies , Fasting/blood , Female , Humans , Insulin/blood , Insulin Resistance , Magnetic Resonance Spectroscopy , Male , Particle Size , Triglycerides/blood
10.
Arch Phys Med Rehabil ; 96(6): 1071-9, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25660005

ABSTRACT

OBJECTIVE: Increased prevalence of heart rate and blood pressure abnormalities are evident in persons with spinal cord injury (SCI), but age, comorbid medical conditions, and prescription medication use may contribute. To determine differences in the prevalence of cardiac acceleration (heart rate ≥80 beats per minute), hypotension (blood pressure ≤110/70mmHg), orthostatic hypotension (OH) (-20/-10mmHg with upright positioning), and hypertension (HTN) (blood pressure ≥140/90mmHg) in veterans with and without SCI. DESIGN: Observational trial. SETTING: Medical center. PARTICIPANTS: Subjects included veterans with SCI (n=62; cervical: tetraplegia, C3-8; high thoracic, T1-5; low thoracic, T7-L2) and veterans without SCI (n=160). INTERVENTIONS: None. MAIN OUTCOME MEASURES: We assessed medical history, prescription medication use, and heart rate and blood pressure during a routine clinical visit. Prevalence rates of cardiac acceleration, hypotension, OH, and HTN were calculated using binary logistic regression analysis with 95% confidence intervals. The influence of SCI status, age, smoking status, cardiovascular diagnoses, and use of prescribed antihypertensive medications on the prevalence of abnormal heart rate and blood pressure recordings was determined. RESULTS: The diagnosis of HTN was reduced in the high thoracic and tetraplegia groups compared with the non-SCI and low thoracic groups. Use of antihypertensive medications was increased in the low thoracic group compared with the other 3 groups and was increased in the non-SCI group compared with the tetraplegia group. The prevalence of cardiac acceleration was reduced, and the prevalence of systolic hypotension was increased in the tetraplegia group. The prevalence of diastolic hypotension was increased in all SCI groups compared with the non-SCI group. For all analyses, increased prevalence of abnormal heart rate and blood pressure recordings was not further explained by the covariates, with the exception of age, cardiovascular diagnoses, and antihypertensive medications in the cardiac acceleration model; however, SCI status remained significant and was the dominant predictor variable. CONCLUSIONS: Our data suggest that SCI status contributes to the prevalence of cardiac acceleration and systolic and diastolic hypotension regardless of cardiovascular medical conditions or prescription antihypertensive medication use.


Subject(s)
Heart Rate/physiology , Hypertension/epidemiology , Hypotension/epidemiology , Spinal Cord Injuries/epidemiology , Spinal Cord Injuries/physiopathology , Veterans , Adult , Aged , Aged, 80 and over , Antihypertensive Agents/therapeutic use , Case-Control Studies , Female , Humans , Male , Middle Aged , Quadriplegia/epidemiology , Quadriplegia/physiopathology , United States/epidemiology , Young Adult
11.
J Clin Gastroenterol ; 49(9): 751-6, 2015 Oct.
Article in English | MEDLINE | ID: mdl-25599220

ABSTRACT

BACKGROUND: Poor preparation for elective colonoscopy is exceedingly common in persons with spinal cord injury (SCI). This unsatisfactory outcome is likely due to long-standing difficulty with evacuation and decreased colonic motility, which may result in inadequate responses to conventional bowel preparation regimens. We determined whether the addition of neostigmine to MoviPrep before elective colonoscopy produced a higher percentage of acceptable bowel preparations in patients with SCI. METHODS: Twenty-seven SCI subjects were prospectively randomized to 1 of 2 arms: low-volume polyethylene glycol-electrolyte lavage with ascorbic acid (MoviPrep) or MoviPrep plus neostigmine methylsulfate and glycopyrrolate (MoviPrep+NG); 28 able-bodied subjects received MoviPrep alone. The quality of the cleansing preparation for colonoscopy was determined by gastroenterologists "calibrated" to use the Ottawa Scoring System, with an acceptable Ottawa Score (OS) considered to be ≤3. RESULTS: The administration of MoviPrep alone resulted in suboptimal bowel cleansing in the SCI group compared with the able-bodied group (50% vs. 89% of subjects had an acceptable OS; χ=7.94, P=0.05). However, when NG was added to MoviPrep in the SCI group, it markedly improved the quality of the bowel preparation, with 85% of patients then having an acceptable OS. The use of NG resulted in minimal bloating and distention before bowel evacuation (P=0.0005), and eye and muscle twitching; these were resolved within 1 hour after NG administration. No significant differences were noted among the preparation groups for adenoma detection rate (P=0.41). CONCLUSIONS: The combination of MoviPrep+NG was safe, well tolerated, and an effective approach to prepare the bowel for elective colonoscopy in patients with SCI. The side effects of this preparation were significant compared with the other treatment groups but were considered mild and anticipated.


Subject(s)
Cathartics/administration & dosage , Colonoscopy/methods , Neostigmine/administration & dosage , Spinal Cord Injuries/complications , Aged , Cathartics/adverse effects , Cholinesterase Inhibitors/administration & dosage , Cholinesterase Inhibitors/adverse effects , Glycopyrrolate/administration & dosage , Glycopyrrolate/adverse effects , Humans , Middle Aged , Neostigmine/adverse effects , Polyethylene Glycols/administration & dosage , Polyethylene Glycols/adverse effects , Prospective Studies
12.
J Spinal Cord Med ; 38(6): 805-11, 2015 Nov.
Article in English | MEDLINE | ID: mdl-25096918

ABSTRACT

BACKGROUND: Poor preparation for elective colonoscopy is common in persons with spinal cord injury (SCI). This unsatisfactory outcome is likely due to long-standing difficulty with evacuation and decreased colonic motility. Our objective was to determine the most effective preparation for elective colonoscopy applying a novel and traditional approach to bowel cleansing. METHODS: Twenty-four subjects with SCI were consented and scheduled to receive one of the two possible arms: pulsed irrigation enhanced evacuation (PIEE) or polyethylene glycol-electrolyte lavage solution (PEG; CoLyte(®)). The quality of the preparation was scored during the colonoscopy by applying the Ottawa scoring system. RESULTS: Patients with SCI who received PIEE tended to have lower Ottawa scores and a higher percentage of acceptable preparations than did those who received PEG; however, the results were not statistically different. CONCLUSION: In this preliminary study in subjects with SCI, neither PIEE nor PEG produced acceptable bowel preparation for elective colonoscopy. Future studies should confirm our findings and consider studying alternative, more efficacious approaches to bowel cleansing prior to colonoscopic procedures in patients with SCI, which should provide better outcomes. Registration number for clinicaltrials.gov: NCT00745095.


Subject(s)
Colonoscopy/methods , Electrolytes/adverse effects , Polyethylene Glycols/adverse effects , Spinal Cord Injuries/complications , Therapeutic Irrigation/adverse effects , Adolescent , Adult , Aged , Female , Humans , Intestines/drug effects , Male , Middle Aged , Preoperative Care/methods , Therapeutic Irrigation/methods , Veterans
13.
J Spinal Cord Med ; 36(5): 454-62, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23941793

ABSTRACT

OBJECTIVE: Decentralized autonomic cardiovascular regulation may lead to increased prevalence of heart rate (HR) and blood pressure (BP) abnormalities in veterans with SCI. In addition, comorbid medical conditions and prescription medication use may increase HR and BP abnormalities. These abnormalities include bradycardia, and tachycardia, hypotension, hypertension as well as autonomic dysreflexia and orthostatic hypotension; the prevalence of which is unknown. DESIGN: HR and BP data were measured during a routine annual physical examination in 64 veterans with SCI. Measurements of HR and BP were recorded in the seated and supine positions to document the influence of body position and to document intra-subject variability in these assessments. RESULTS: All subjects were chronically injured (20 ± 14 years), 33 subjects were tetraplegic (T: C3-C8), nine had high paraplegia (HP: T1-T6), and 22 had low paraplegia (LP: T7-L2). Regardless of position, the prevalence of bradycardia was increased in the T group, whereas prevalence of tachycardia was increased in the HP and LP groups. Systolic hypotension was more common in the T and HP groups than the LP group and positional effects were most evident in the T group. Systolic hypertension was comparable in the T and HP groups but was twice as prevalent in the LP group. Increased prevalence of individuals with three or more medical conditions and prescribed three or more medications which might influence HR and BP was observed. CONCLUSION: Decentralized autonomic regulation, comorbid medical conditions, and prescription medication use in veterans with SCI result in HR and BP abnormalities; our data suggest that these abnormalities vary depending on the level of injury and orthostatic positioning.


Subject(s)
Bradycardia/epidemiology , Hypertension/epidemiology , Hypotension/epidemiology , Spinal Cord Injuries/epidemiology , Tachycardia/epidemiology , Veterans/statistics & numerical data , Adult , Aged , Autonomic Dysreflexia/epidemiology , Autonomic Dysreflexia/physiopathology , Blood Pressure/physiology , Bradycardia/physiopathology , Comorbidity , Female , Heart Rate/physiology , Humans , Hypertension/physiopathology , Hypotension/physiopathology , Hypotension, Orthostatic/epidemiology , Hypotension, Orthostatic/physiopathology , Male , Middle Aged , Prevalence , Prospective Studies , Spinal Cord Injuries/physiopathology , Tachycardia/physiopathology
14.
J Spinal Cord Med ; 36(5): 463-75, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23941794

ABSTRACT

OBJECTIVE: Autonomic impairment may lead to increased prevalence of heart rate (HR) and blood pressure (BP) abnormalities in veterans with spinal cord injury (SCI). In addition, comorbid medical conditions and prescription medication use may influence these abnormalities, including bradycardia, and tachycardia, hypotension, hypertension as well as autonomic dysreflexia (AD), and orthostatic hypotension (OH). DESIGN: A retrospective review of clinical and administrative datasets in veterans with SCI and compared the prevalence rates between clinical values and ICD-9 diagnostic codes in individuals with tetraplegia (T: C1-C8), high paraplegia (HP: T1-T6), and low paraplegia (LP: T7 and below). RESULTS: The prevalence of clinical values indicative of a HR ≥ 80 beats per minute was higher in the HP compared to the LP and T groups. A systolic BP (SBP) ≤ 110 mmHg was more common in the T compared to the HP and LP groups, whereas the prevalence of a SBP ≥ 140 mmHg was increased in the LP compared to the HP and T groups. Diagnosis of hypertension was 39-60% whereas the diagnosis of hypotension was less than 1%. Diagnosis of AD and OH was highest in the T group, but remained below 10%, regardless of categorical lesion level. Antihypertensive medications were commonly prescribed (55%), and patients on these medications were less likely to have high BP. The odds ratio of higher SBP and DBP increased with age and body mass index (BMI). CONCLUSION: In veterans with SCI, the prevalence of HR and BP abnormalities varied depending on level of lesion, age, BMI, and prescription medication use.


Subject(s)
Bradycardia/epidemiology , Hypertension/epidemiology , Hypotension/epidemiology , Spinal Cord Injuries/epidemiology , Tachycardia/epidemiology , Veterans/statistics & numerical data , Adult , Autonomic Dysreflexia/drug therapy , Autonomic Dysreflexia/epidemiology , Autonomic Dysreflexia/physiopathology , Blood Pressure/physiology , Bradycardia/drug therapy , Bradycardia/physiopathology , Comorbidity , Drug Utilization/statistics & numerical data , Female , Heart Rate/physiology , Humans , Hypertension/drug therapy , Hypertension/physiopathology , Hypotension/drug therapy , Hypotension/physiopathology , Hypotension, Orthostatic/drug therapy , Hypotension, Orthostatic/epidemiology , Hypotension, Orthostatic/physiopathology , Male , Middle Aged , Paraplegia/drug therapy , Paraplegia/epidemiology , Paraplegia/physiopathology , Prescription Drugs , Prevalence , Quadriplegia/drug therapy , Quadriplegia/epidemiology , Quadriplegia/physiopathology , Retrospective Studies , Spinal Cord Injuries/drug therapy , Spinal Cord Injuries/physiopathology , Tachycardia/drug therapy , Tachycardia/physiopathology
15.
World J Gastroenterol ; 16(43): 5435-9, 2010 Nov 21.
Article in English | MEDLINE | ID: mdl-21086560

ABSTRACT

AIM: To investigate the presence or absence of high amplitude propagating contractions (HAPC), as well as the other measures of colonic motility, in persons with spinal cord injury (SCI). METHODS: Prolonged colonic ambulatory manometric studies were performed on 14 male volunteers: 8 with SCI (mean age, 59 ± 13 years; mean duration of injury, 13 ± 4 years) and 6 healthy able-bodied controls (mean age, 57 ± 10 years). A solid-state manometry catheter was endoscopically clipped to the splenic flexure. Recording was performed for > 24 h after manometric catheter placement. RESULTS: HAPC were absent in individuals with SCI during pre-sleep, sleep, and post-sleep phases. HAPC were significantly increased after awakening in non-SCI controls (0.8 ± 0.2 HAPC/h vs 10.5 ± 2.0 HAPC/h, P < 0.005). The motility index was lower in those with SCI than in controls pre- and post-sleep (SCI vs non-SCI: Pre-sleep, 2.4 ± 0.4 vs 8.8 ± 1.9, P < 0.01; Post-sleep, 4.3 ± 0.8 vs 16.5 ± 4.5, P < 0.05). However, a sleep-induced depression of colonic motility was observed in both the SCI and non-SCI groups (Pre-sleep vs Sleep, non-SCI: 8.8 ± 1.9 vs 2.1 ± 0.9, P < 0.002; SCI: 2.4 ± 0.4 vs 0.2 ± 0.03, P < 0.001), with the motility index of those with SCI during sleep not significantly different than that of the controls. CONCLUSION: HAPC were not observed in individuals with SCI pre- or post-sleep. A sleep-induced depression in general colonic motility was evident in SCI and control subjects.


Subject(s)
Gastrointestinal Motility/physiology , Peristalsis/physiology , Spinal Cord Injuries/physiopathology , Aged , Case-Control Studies , Chronic Disease , Humans , Male , Manometry , Middle Aged , Muscle Contraction/physiology , Sleep/physiology
16.
J Am Coll Nutr ; 29(5): 476-81, 2010 Oct.
Article in English | MEDLINE | ID: mdl-21504974

ABSTRACT

BACKGROUND: Postprandial lipemia (PPL) is associated with vascular dysfunction and may be an etiologic factor in the progression of atherogenic cardiovascular disease. OBJECTIVE: In 10 men with paraplegia and 10 able-bodied men, the magnitude of the PPL responses and the relationship of abdominal adiposity and the PPL responses were determined. METHODS: Anthropometrics, dual energy x-ray absorptiometry, and abdominal ultrasonography were performed to determine visceral fat and total body fat. A fasting lipid profile was performed. A high-fat milkshake (1.3 g fat/kg body mass) was administered with serum collected at baseline and at 2, 4, and 6 hours after the test meal for subsequent measurement of triglyceride. The triglyceride response was determined by the area under the triglyceride curve. RESULTS: No significant differences were noted between the groups in fasting lipid values or in measures of visceral fat. Total body fat tended to be higher in men with paraplegia than in able-bodied men (34.9 ± 10.0 vs. 27.3 ± 6.7%, p = 0.07). No significant difference between the groups was observed in triglyceride response. In men with paraplegia, visceral fat was strongly associated with the triglyceride (r = 0.8, p = 0.005), fasting low-density lipoprotein (r = 0.66, p = 0.04), and triglyceride responses (r = 0.80, p = 0.005); a significant relationship was not found between fasting high-density lipoprotein and any measure of adiposity. In men with paraplegia, triglyceride response was positively related to all measures of abdominal adiposity. CONCLUSION: Visceral abdominal fat was related to delayed triglyceride clearance after a fat load, which may contribute to coronary heart disease (CHD) risk and progression of vascular disease in men with paraplegia.


Subject(s)
Dietary Fats/blood , Hyperlipidemias/etiology , Intra-Abdominal Fat/physiology , Obesity, Abdominal/complications , Paraplegia/complications , Triglycerides/blood , Adipose Tissue/diagnostic imaging , Adult , Cardiovascular Diseases/blood , Cardiovascular Diseases/etiology , Case-Control Studies , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Fasting , Humans , Hyperlipidemias/blood , Intra-Abdominal Fat/diagnostic imaging , Male , Middle Aged , Obesity, Abdominal/blood , Paraplegia/blood , Postprandial Period , Ultrasonography
17.
Telemed J E Health ; 12(2): 160-2, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16620171

ABSTRACT

The care of a spinal cord injury (SCI) person constitutes a great challenge for the provider: SCI persons are mobility impaired, and they are prone to develop multiple comorbidities such as diabetes mellitus, hypertension, obesity, bladder infections, wounds, and depression. Furthermore, disease manifestations can be misleading depending on the level of injury. The utilization of telemedicine to monitor patients and deliver care has opened a new horizon for SCI persons. Several telehealth programs are now in use to monitor pressure ulcers and postdischarge rehabilitation in SCI persons. To answer the need for a more comprehensive approach to the multifaceted manifestation of SCI at the James J. Peters VAMC, we have started a customized telerehabilitation program. The program monitors the most common comorbidities of SCI, it is instrumental in the reintegration of the SCI person in the community, it offers individualized in-home rehabilitation programs, it addresses safety issues, and it offers counseling, weight reduction, and maintenance plans. A team of SCI specialists-including an internist, a registered nurse, a physical therapist, a nutritionist, a psychologist, and a recreational therapist-are available for weekly meetings with the patients. The programs are tailored to the patients' needs and agreed upon by both parties. Both messaging devices and video monitors are utilized. An interdisciplinary template is used to record assessments and plans. Preliminary results are encouraging; coordination of the team and relative poor technology are some of the obstacles we have identified. Further evaluation is necessary to determine cost effectiveness.


Subject(s)
Home Care Services , Spinal Cord Injuries/rehabilitation , Telemedicine , Humans , New England , Patient-Centered Care , Program Development , Spinal Cord Injuries/complications , United States
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