ABSTRACT
The Ukrainian INEC Section is the most recently established chapter of the European Institute of Ecology and Cancer (INEC). We herewith review its organization and goals, membership, scientific platform, and areas of scientific activity.
Subject(s)
Ecology , Neoplasms/epidemiology , Societies, Medical/organization & administration , Humans , Societies, Medical/trends , UkraineABSTRACT
Inhalation of nitrogen dioxide (NO2) by mice administered orally amidopyrine (AP) and sodium nitrite resulted in increased biosynthesis of N-nitrosodimethylamine (NDMA), as determined by analysis using gas chromatography with thermal energy analyzer detector. These results were also confirmed indirectly in chronic experiments on rats using the system of biomarkers of NDMA formation (single-stranded DNA liver damages, alanine-aminotransferase, glutathione-S-transferase, and liver S9 fraction activity). The inhibition of NDMA metabolism by 4-methylpyrazol (4-MP) administration increases the sensitivity of NDMA biosynthesis assay in frozen whole-mouse powder. The results confirm that NO2 can serve as the precursor of nitrosamines.