ABSTRACT
The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk. Aims of the study were to evaluate a possible association between the above-mentioned drugs and features such as number and atypia of melanocytic nevi in long-term users. We retrospectively looked at pharmacological, clinical and dermoscopic records of 1321 patients that attended our unit for routine mole check between January 2013 and January 2018. Patients were divided into two groups (low or high melanocytic nevi count), and multivariate analysis was performed with regards to the presence and number of melanocytic nevi and drug assumption. A positive association between the use of oral contraceptives or hormone replacement therapy (P = 0.012) and a high melanocytic nevi count was found through multivariate analysis, after adjusting for sex, age and multiple confounding factors, such as freckles, phototype and a reported history of sun exposure and sunburns. Further prospective studies are necessary to establish whether women using oral contraceptives or on hormone replacement therapy should undergo periodic monitoring of pigmented lesions.
Subject(s)
Contraceptives, Oral/adverse effects , Hormone Replacement Therapy/adverse effects , Nevus, Pigmented/epidemiology , Skin Neoplasms/epidemiology , Adult , Aged , Case-Control Studies , Dermoscopy/statistics & numerical data , Female , Hormone Replacement Therapy/statistics & numerical data , Humans , Male , Middle Aged , Nevus, Pigmented/diagnosis , Retrospective Studies , Risk Factors , Severity of Illness Index , Skin/diagnostic imaging , Skin Neoplasms/diagnosisSubject(s)
Chernobyl Nuclear Accident , Thyroiditis, Autoimmune/etiology , Vitiligo/etiology , Adult , Female , Humans , Middle Aged , Time FactorsABSTRACT
BACKGROUND: In order to treat onychomycosis, topical and systemic medications are available. The choice of a systemic or topic treatment depends on numerous factors, such as patient's age, the presence of comorbidity, responsible fungal species, the clinical form of onychomycosis, its location (fingernails or toenails), the number of nails affected and the percentage of the nail plate infected. As for topical medications, given that nail plate has an insufficiently permeable structure, it is necessary to use appropriate formulae that create in the surface of the nail plate a film able, in turn, to function both as an active ingredient's deposit and moisturising agent in nail's superficial layers in order to facilitate the spread of the active ingredient. In this manuscript, we wanted to evaluate the effectiveness and tolerability rate of a new topical formulation (Miconal Nails®, Morgan srl, Vicenza, Italy) composed of hydrogenated castor oil, hydroxyethyl cellulose, and other ingredients (urea, climbazole, piroctone olamine, undecylenic acid). METHODS: We selected 25 patients of both sexes whose median age was between 20 and 70 years, and were affected by onychomycosis in a single toe. Their onychomycosis was a distolateral subungual type (with a <50% invasion of nail plate and sparing of lunula) and white superficial. The treatment was evaluated with the following possible outcomes: complete healing, improvement, stationarity, worsening. RESULTS: Patients were 11 female subjects and 14 male subjects, whose median age was 45. A complete healing was achieved in 15 patients. In 3 cases the clinical presentation appeared unchanged with a persistence of mycological evidence. The response to the treatment was assessed as improvement in 7 patients. CONCLUSIONS: In our experience, this new product is an effective weapon that enhances the therapeutic selection of topical formulae for treating onychomycosis. If used alone in the cases that meet inclusion criteria for topical treatment, it allowed us to achieve a complete healing just with a 5-month treatment in 60% of cases, data that reached 76% on the follow-up visit.
Subject(s)
Antifungal Agents/administration & dosage , Foot Dermatoses/drug therapy , Onychomycosis/drug therapy , Administration, Topical , Adult , Aged , Antifungal Agents/adverse effects , Female , Follow-Up Studies , Humans , Italy , Male , Middle Aged , Treatment Outcome , Young AdultSubject(s)
Dexamethasone/administration & dosage , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Neoplasm Recurrence, Local/drug therapy , Oral Ulcer/chemically induced , Prednisone/administration & dosage , Purines/adverse effects , Quinazolinones/adverse effects , Follow-Up Studies , Humans , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Male , Middle Aged , Mouth Mucosa/drug effects , Mouth Mucosa/pathology , Neoplasm Recurrence, Local/pathology , Oral Ulcer/drug therapy , Oral Ulcer/physiopathology , Purines/therapeutic use , Quinazolinones/therapeutic use , Risk Assessment , Severity of Illness Index , Treatment OutcomeSubject(s)
Fibroma/diagnosis , Hair Follicle/pathology , Hamartoma/diagnosis , Skin Diseases/diagnosis , Adult , Female , Fibroma/pathology , Hamartoma/pathology , Hip , Humans , Skin Diseases/pathologySubject(s)
Drug Eruptions/etiology , Lichenoid Eruptions/chemically induced , Thienopyridines/adverse effects , Clopidogrel , Drug Eruptions/diagnosis , Drug Eruptions/pathology , Humans , Lichenoid Eruptions/diagnosis , Lichenoid Eruptions/pathology , Male , Middle Aged , Thienopyridines/administration & dosage , Ticlopidine/administration & dosage , Ticlopidine/adverse effects , Ticlopidine/analogs & derivativesSubject(s)
Melanoma, Amelanotic/diagnosis , Skin Neoplasms/diagnosis , Toes , Aged , Carcinoma, Verrucous/diagnosis , Diagnosis, Differential , Humans , MaleABSTRACT
Lipoatrophia semicircularis is characterised by band-like horizontal skin depressions involving the anterior and lateral sides of the lower limbs. Whether this occurrence is rare or is just not well known or simply underreported because it does not cause patient distress is still under discussion. In a 1-year period we observed three cases due to local, mechanical pressure in an Italian dermatology outpatient clinic. However, other factors described in current literature may contribute to this phenomenon. More large-scale studies are needed to clearly assess the origin of this condition.
