1.
ChemMedChem
; 3(10): 1508-15, 2008 Oct.
Article
in English
| MEDLINE
| ID: mdl-18729128
Subject(s)
Antiviral Agents/chemical synthesis , Antiviral Agents/pharmacology , Hepacivirus/drug effects , Pyrans/chemical synthesis , Pyrans/pharmacology , RNA-Dependent RNA Polymerase/antagonists & inhibitors , Viral Nonstructural Proteins/antagonists & inhibitors , Allosteric Regulation , Animals , Antiviral Agents/chemistry , Hepacivirus/genetics , Hepacivirus/metabolism , Indoles/chemical synthesis , Indoles/chemistry , Indoles/pharmacology , Inhibitory Concentration 50 , Mice , Mice, SCID , Mice, Transgenic , Pyrans/chemistry , RNA, Viral/blood , RNA, Viral/isolation & purification , RNA-Dependent RNA Polymerase/metabolism , Viral Nonstructural Proteins/metabolism
2.
Inorg Chem
; 45(19): 7815-20, 2006 Sep 18.
Article
in English
| MEDLINE
| ID: mdl-16961373
ABSTRACT
New carborane-containing dendrons based on a 2,2-bis(hydroxymethyl)propanoic acid scaffold have been prepared for applications in boron neutron capture therapy. A generation-2 carborane-containing dendron carrying 40 boron atoms was the highest generation synthetically available due to the steric crowding. The structure of this dendron has been simulated by molecular dynamics. A 10-carbon linker carrying a carboxylic group has been installed at the focal point of the dendron to distance the attachment point from the sterically hindered core.