ABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Child , Adolescent , Eosinophilic Esophagitis/drug therapy , Omeprazole/administration & dosage , Prospective Studies , Endoscopy, Gastrointestinal , BiopsyABSTRACT
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Subject(s)
Humans , Female , Middle Aged , Psoriasis/chemically induced , Psoriasis/complications , Drug Hypersensitivity/complications , Drug Hypersensitivity/drug therapy , Exanthema/chemically induced , Exanthema/complications , Heparin/adverse effects , Autoimmune Diseases/chemically induced , Autoimmune Diseases/complications , Enoxaparin/administration & dosageABSTRACT
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Subject(s)
Humans , Female , Middle Aged , Acute Coronary Syndrome/complications , Acute Coronary Syndrome/diagnosis , Amoxicillin/adverse effects , Adrenal Cortex Hormones/therapeutic use , Histamine Antagonists/therapeutic use , Electrocardiography , Troponin/therapeutic useABSTRACT
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Subject(s)
Humans , Female , Adult , Eosinophilic Esophagitis/complications , Eosinophilic Esophagitis/diagnosis , Asthma/epidemiology , Asthma/immunology , Respiratory Tract Infections/epidemiology , Respiratory Tract Infections/immunology , Gastroesophageal Reflux/epidemiology , Gastroesophageal Reflux/prevention & control , Comorbidity , Symptom Flare Up , Esophagoscopy/methodsABSTRACT
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Subject(s)
Humans , Female , Middle Aged , Erythema Multiforme/chemically induced , Erythema Multiforme/complications , Erythema Multiforme/immunology , Muscle Relaxants, Central/adverse effects , Neuromuscular Agents/adverse effects , Patch Tests/instrumentation , Patch Tests/methods , Patch Tests , Antidepressive Agents, Tricyclic/adverse effects , Antidepressive Agents, Tricyclic/immunology , Hypersensitivity, Immediate/chemically induced , Hypersensitivity, Immediate/complications , Mouth Mucosa , Mouth Mucosa/injuriesABSTRACT
BACKGROUND: Hymenoptera venom-allergic patients frequently present multiple sensitisations. OBJECTIVES: To define the allergic profile by components in wasp allergic patients. To study the usefulness of specific IgE to components in cases of double sensitisation. MATERIALS AND METHODS: Wasp allergic patients who needed Polistes and/or Vespula venom immunotherapy were included. Before immunotherapy and after two years of treatment the following specific IgE (sIgE) levels were measured:Apis mellifera, Vespula spp. Polistes spp., rVes V 5, rPol d 5, nVes V 5, nPol d 5, nVes V 1, nPol d 1, nApi m 1, nApi m 2 and peroxidase. Skin tests with venoms were performed. Based on the sIgE and the skin test results, Polistes and/or Vespula immunotherapy was administered. RESULTS: Thirteen patients were included. Double sensitisation to Polistes/Vespula was detected in eight patients. Sensitisation to rVes V 5 and rPol d 5 was found in two of eight cases, to nVes V 1 and nPol d 1 in eight of 13 cases, and to nVes V 5 and nPol d 5 in 2 of 13 cases. Three patients received double immunotherapy with both wasps. One patient was treated with Vespula and nine with Polistes. sIgE levels decreased after two years of treatment. In patients who showed double sensitisation but were treated with only one venom, sIgE to both venoms decreased. CONCLUSIONS: Components analysis can be useful to study double positivity. In case of doubt, double immunotherapy should be administered. Phospholipase was found to be a major allergen in our population
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Subject(s)
Humans , Wasp Venoms/adverse effects , Hypersensitivity/immunology , Hymenoptera/pathogenicity , Wasp Venoms/analysis , Allergens/isolation & purification , Desensitization, Immunologic/methodsABSTRACT
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Subject(s)
Humans , Male , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Allergic Contact/genetics , Rhinitis, Allergic, Seasonal/genetics , Rhinitis, Allergic, Seasonal/metabolism , Hemorrhoids/diagnosis , Skin Tests/methods , Dermatitis, Allergic Contact/metabolism , Dermatitis, Allergic Contact/prevention & control , Rhinitis, Allergic, Seasonal/prevention & control , Hemorrhoids/complications , Skin Tests/instrumentation , Skin Tests/standardsABSTRACT
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic inflammatory emerging disease of the oesophagus with immunoallergic aetiology. The allergens involved have not been clearly defined and may depend on the exposure of the population to aeroallergens or food antigens. MATERIALS AND METHODS: Patients diagnosed with EoE between 2006 and 2011 were referred to our Allergy Section. Patch and skin prick tests (SPT) with aeroallergens and foods were performed, and total and specific IgE levels, eosinophil cationic protein levels and eosinophil count were determined. RESULTS: 43 patients were included. 36 (83.7%) were atopic. 29 patients presented choking, 19 dysphagia, 9 food impaction with urgent endoscopy, 4 chest pain, 1 isolated vomiting and 1 epigastric pain. 22 had two or more symptoms. The mean duration of symptoms was 3.73 years. Concomitant allergic diseases included rhinoconjunctivitis and/or asthma (31 patients), IgE food allergy (21 patients) and atopic dermatitis (3 patients).32 (74%) were sensitized to aeroallergens, of which 90% were sensitized to pollens; 23 (54%) showed positive tests to foods and 12 of them (52%) to lipid transfer proteins (LTP).Of the 29 pollen-allergic patients, 15 (52%) were sensitized to plant foods and 10 (34.4%) to LTP. CONCLUSIONS: Our findings support those reported in the literature: the disease is more common in men aged 30-40 years with at least a three-year history of symptoms of esophageal dysfunction, sensitized to pollens, the predominant aeroallergen in our area, but also to plant foods or panallergens. These results increase the evidence for an immunoallergic aetiology and can help us in the early diagnosis of EoE
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