Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Exp Neurol ; 347: 113914, 2022 01.
Article in English | MEDLINE | ID: mdl-34752783

ABSTRACT

Pregnancy is an inflammatory process that is carefully regulated by the placenta via immunomodulation and cell-to-cell communication of maternal and fetal tissues. Exosomes, types of extracellular vesicles, facilitate the intercellular communication and traffic biologically modifying cargo within the maternal-placental-fetal axis in normal and pathologic pregnancies. Chorioamnionitis is characterized by inflammation of chorioamniotic membranes that produces systemic maternal and fetal inflammatory responses of cytokine dysregulation and has been associated with brain injury and neurodevelopmental disorders. This review focuses on how pathologic placental exosomes propagate acute and chronic inflammation leading to brain injury. The evidence reviewed here highlights the need to investigate exosomes from pathologic pregnancies and those with known brain injury to identify new diagnostics, biomarkers, and potential therapeutic targets.


Subject(s)
Brain Injuries/metabolism , Chorioamnionitis/metabolism , Exosomes/metabolism , Inflammation Mediators/metabolism , Placenta/metabolism , Brain Injuries/pathology , Chorioamnionitis/pathology , Exosomes/pathology , Female , Humans , Inflammation/metabolism , Inflammation/pathology , Placenta/pathology , Pregnancy
SELECTION OF CITATIONS
SEARCH DETAIL
...