ABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Diplopia/etiology , Osteoma/complications , Ethmoid Sinus/pathology , Bone Neoplasms/complications , Exophthalmos/etiologySubject(s)
Diplopia/etiology , Ethmoid Bone/diagnostic imaging , Exophthalmos/etiology , Frontal Bone/diagnostic imaging , Osteoma/complications , Skull Neoplasms/complications , Aged , Ethmoid Bone/surgery , Humans , Male , Osteoma/diagnostic imaging , Osteoma/surgery , Skull Neoplasms/diagnosis , Skull Neoplasms/surgeryABSTRACT
Whipple's disease is a rare systemic infectious disease caused by the bacterium Tropheryma whippelii. Early diagnosis is essential. Whipple's disease is potentially fatal but responds dramatically to antibiotic treatment. The diagnosis is confirmed by means of polymerase chain reaction (PCR) technology. This analysis may be useful for monitoring the efficacy of therapy. The recommended treatment al present is administration of cotrimoxazole twice daily for one year. When CNS involvement occurs, it is recommended initial treatment with daily parenteral administration of streptomycin 1 g and 1.2 million units of benzyl penicillin (Penicillin G) over a period of 14 days.
Subject(s)
Whipple Disease/diagnosis , Aged , Anemia/etiology , Arthritis, Infectious/diagnosis , Arthritis, Infectious/etiology , Biopsy , DNA, Bacterial/isolation & purification , Diarrhea/etiology , Duodenal Diseases/etiology , Duodenal Diseases/microbiology , Duodenal Diseases/pathology , Female , Folic Acid/therapeutic use , Gastrointestinal Hemorrhage/etiology , Gram-Positive Bacteria/genetics , Gram-Positive Bacteria/isolation & purification , Heart Failure/etiology , Heart Valve Diseases/etiology , Heart Valve Diseases/surgery , Humans , Laparotomy , Male , Penicillin G/therapeutic use , Polymerase Chain Reaction , Streptomycin/therapeutic use , Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use , Weight Loss , Whipple Disease/drug therapyABSTRACT
La enfermedad de Whipple, también conocida como lipodistrofia intestinal, es un proceso infeccioso, multisistémico y poco frecuente, causado por la bacteria Tropheryma whippelii. El diagnóstico precoz es fundamental porque esta enfermedad es potencialmente letal, pero responde espectacularmente al tratamiento antibiótico. El diagnóstico se confirma con la reacción en cadena de la polimerasa (PCR) que también es útil para monitorizar la respuesta al tratamiento. Actualmente el tratamiento recomendado consiste en la administración de cotrimoxazol oral dos veces al día durante un año. Cuando hay afectación del SNC se aconseja iniciar el tratamiento con la administración intramuscular de 1 gramo de estreptomicina asociado a 1,2 MU de bencil penicilina (penicilina G) de forma diaria durante 14 días
Whipples disease is a rare systemic infectious disease caused by the bacterium Tropheryma whippelii. Early diagnosis is essential. Whipples disease is potentially fatal but responds dramatically to antibiotic treatment. The diagnosis is confirmed by means of polymerase chain reaction (PCR) technology. This analysis may be useful for monitoring the efficacy of therapy. The recommended treatment al present is administration of cotrimoxazole twice daily for one year. When CNS involvement occurs, it is recommended initial treatment with daily parenteral administration of streptomycin 1 g and 1,2 million units of benzyl penicillin (Penicillin G) over a period of 14 days
Subject(s)
Adult , Humans , Whipple Disease/diagnosis , Whipple Disease/pathology , Trimethoprim, Sulfamethoxazole Drug Combination/chemical synthesis , Trimethoprim, Sulfamethoxazole Drug Combination , Macrophages/classification , Whipple Disease/etiology , Polymerase Chain Reaction , Macrophages/physiology , Tomography, X-Ray Computed/methodsSubject(s)
Pulmonary Artery/pathology , Sarcoma/pathology , Vascular Neoplasms/pathology , Aged , Anticoagulants/therapeutic use , Biopsy, Fine-Needle , Diagnosis, Differential , Female , Humans , Pulmonary Artery/diagnostic imaging , Pulmonary Embolism/diagnosis , Pulmonary Embolism/diagnostic imaging , Pulmonary Embolism/drug therapy , Sarcoma/diagnostic imaging , Sarcoma/therapy , Tomography, X-Ray Computed , Vascular Neoplasms/diagnostic imaging , Vascular Neoplasms/therapyABSTRACT
Objetivos: Valorar la situación del eje hipófiso-suprarrenal en pacientes con alcoholismo crónico. Método: Se estudiaron 24 pacientes alcohólicos crónicos ingresados en nuestro centro en situación de delirio agudo. Se determinaron cortisolemia a.m. y p.m. y niveles de ACTH a.m.junto a serie roja con sus índices de Wintrobe, número de plaquetas, trigliceridemia, colesterolemia total y HDL y actividad de transaminasas, fosfatasa alcalina y gammaglutamiltranspeptidasa en el suero. Resultados: Las cifras medias de ACTH a.m. fueron de 41.2 pcg/ml para valores normales de 10-80 pcg/ml, las de cortisolemia a.m. de 22 mcg/ml (rango normal 5-25 mcg/ml) y las de cortisolemia p.m. de 12.3 mcg/ml (tango normal 5-15 mcg/ml). Conclusiones: Las cantidades de alcohol ingeridas por los pacientes alcohólicos no parecen equiparables a las utilizadas y a las que condicionan una hiperfunción suprarrenal en la experimentación animal. Los niveles de ACTH en sangre y de cortisolemia no son útiles como parámetros indirectos de alcoholismo. Al respecto, destacan como más efectivos los índices de Wintrobe y la actividad de gammaglutamiltranspeptidasa en el suero. (AU)
Subject(s)
Middle Aged , Aged , Adult , Humans , Triglycerides , Biomarkers , Platelet Count , Alkaline Phosphatase , Alcoholism , Hydrocortisone , gamma-Glutamyltransferase , Pituitary-Adrenal System , Pituitary-Adrenal Function Tests , Adrenocorticotropic Hormone , Cholesterol, HDLABSTRACT
OBJECTIVES: To study the situation of the hypophyso-adrenal axis in patients with chronic alcoholism. METHOD: 24 patients with chronic alcoholism admitted in our Institution with acute delirium were studied. Cortisol am and pm und (ACTH levels, along with hemogram with Wintrobe indexes, patelets number, triglicerides, total and HDL cholesterol, transaminases, alkaline phosphatase and gammaglutamyltranspeptidase were measured in serum. RESULTS: The mean values of ACTH am were 41.2 pcg/ml (normal values 10-80 pcg/ml), of plasma cortisol am 22 mcg/ml (normal values 10-24 mcg/ml) and plasmo cortisol pm 12.3 mcg/ml (normal values 5-12 mcg/ml). CONCLUSIONS: The amount of alcohol consumed by alcoholic patients ist not comparable to that used in animal models, which induced adrenal hyperfunction. Blood ACTH and cortisol levels are not useful as indirect markers of alcoholism. The Wintrobe indexes and serum gammaglutamyltranspeptidase levels are more useful for that purpose.
