Years of life lost (Yll) attributable to alcohol consumption in Mexico City.

The aim of this study was to estimate the YLL attributable to alcohol consumption in Mexico City from 2006 - 2012. Vital statistics on mortality attributable to alcohol consumption from the INEGI (Instituto Nacional de Estadística y Geografía) were used to determine YLL as well as the average age of death in relation to different age ranges by sex. A total estimate of 168,607 YLL was obtained, with an average loss of 18.32 years being observed for men and 17.54 years for women. Men accounted for a higher proportion of the YLL than women. According to the ICD-10 (Tenth Revision of International Classification of Diseases), liver disease attributable to alcohol consumption was found to be responsible for more than 80% of the total YLL. There was a cyclical trend in YLL from 2006 to 2012. The YLL attributable to alcohol suggest that alcohol consumption is a public health problem that involves losses in productivity and economic costs, and the decline in YLL could be explained by the decrease in income caused by the economic crisis of 2008, just as the increase could be explained by economic improvement in 2012.

Años de Vida Perdidos (AVP) atribuibles al consumo de alcohol en la ciudad de México / Years of life lost (Yll) attributable to alcohol consumption in Mexico city

Resumen El objetivo de este artículo es estimar los AVP atribuibles al consumo de alcohol en la Ciudad de México durante 2006 – 2012. Se utilizaron las estadísticas vitales de mortalidad del INEGI atribuibles al consumo de alcohol para obtener los AVP, se obtuvieron ademas promedios de edad de muerte respecto a intervalos de edad por sexo. Se estimaron 168,607 AVP, con una pérdida promedio de 18.32 años para los hombres y 17.54 en mujeres. Se encontró una mayor proporción de AVP en hombres que en mujeres. De acuerdo a la CIE-10 se observó que las enfermedades del hígado atribuibles al alcohol, aportan más del 80% de los AVP al total. Existe una tendencia cíclica en los AVP entre 2006 a 2012. Los AVP atribuibles al alcohol apuntan a que el consumo es un problema de salud pública que implican pérdidas en la productividad y costos económicos, mientras la baja en los AVP podría ser explicada por una disminución en el ingreso provocada por la crisis económica de 2008 al igual que el aumento por la mejoría en el 2012.

Abstract The aim of this study was to estimate the YLL attributable to alcohol consumption in Mexico City from 2006 – 2012. Vital statistics on mortality attributable to alcohol consumption from the INEGI (Instituto Nacional de Estadística y Geografía) were used to determine YLL as well as the average age of death in relation to different age ranges by sex. A total estimate of 168,607 YLL was obtained, with an average loss of 18.32 years being observed for men and 17.54 years for women. Men accounted for a higher proportion of the YLL than women. According to the ICD-10 (Tenth Revision of International Classification of Diseases), liver disease attributable to alcohol consumption was found to be responsible for more than 80% of the total YLL. There was a cyclical trend in YLL from 2006 to 2012. The YLL attributable to alcohol suggest that alcohol consumption is a public health problem that involves losses in productivity and economic costs, and the decline in YLL could be explained by the decrease in income caused by the economic crisis of 2008, just as the increase could be explained by economic improvement in 2012.

Asociación del consumo de sustancias psicoactivas con el cuidado y la salud del adulto mayor / Association of psychoactive substances use with care and health of older adults

Antecedentes El consumo de alcohol, tabaco y otras drogas tiene repercusiones importantes en la vida diaria de los adultos mayores. Con el objeto de conocer la asociación entre consumo de sustancias psicoactivas y variables de cuidado y salud en adultos mayores. Método Se recopiló información de una muestra aleatoria del padrón de usuarios del IAAM-DF. 2098 personas aceptaron participar y fueron entrevistadas en sus hogares, su tasa de respuesta fue de 83.9%. Resultados y discusión Se encontró que 13.1% requiere de ayuda en actividades básicas e instrumentales de la vida diaria; 81.4% percibe poco apoyo social; 82.2% señala pertenecer a una familia disfuncional, y a 45.5% le ha sido diagnosticada una enfermedad crónico-degenerativa. Mediante razón de momios se determinó que el consumo riesgoso de alcohol y la dependencia de éste por adultos mayores incrementan en ellos el riesgo de padecer enfermedades crónico-degenerativas, infecciosas y trastornos mentales, e influyen en su necesidad de recibir apoyo en actividades básicas e instrumentales de la vida diaria , así como en su percepción de disfunción familiar. El consumo de tabaco aumentó el riesgo de padecer enfermedades crónico-degenerativas e infecciosas, y se asocia con la percepción de salud y apoyo familiar. La ingestión de alguna droga, ilegal o prescrita, no se asoció significativamente con variables de cuidado, pero sí impacta en la aparición de enfermedades crónico-degenerativas y de trastornos mentales. Los resultados muestran que el consumo de alcohol, tabaco y otras drogas influye en la salud y el cuidado de los adultos mayores en la Ciudad de México, por lo cual constituye una tarea urgente atender estas problemáticas para mejorar la calidad de vida de éstos.

Background The use of alcohol, tobacco and other drugs have a significant impact on the daily lives of older adults. In order to study the relationship between substance use, health and care variables in older adults. Method Information was collected in a random sample of the registry users of the DF IAAM program; 2098 people agreed to participate and was interviewed in their homes, the response rate obtained was 83.9%. Results and discussion It was found that 13.1% receive aid in basic and instrumental activities of daily living, 81.4% perceived little social support, 82.2% perceived belonging to a dysfunctional family and 45.5% have been diagnosed with a chronic degenerative disease. Using odds ratios, it was shown that at-risk drinking and alcohol dependence increased the risk of chronic degenerative diseases, infectious and mental disorders and affects the need for support in basic and instrumental activities of daily living and perception of family dysfunction. Smoking increased risk of chronic degenerative and infectious diseases and also was associated with perceived health and family support. The use of any illegal or prescribed drugs was not significantly associated with care variables, but affect chronic degenerative diseases and mental disorders. The results of this study showed that use of alcohol, tobacco and other drugs affect the health and care of older adults in Mexico City, so it is urgent to address these problems in order to improve their quality of life.

Spontaneously hypertensive rat (SHR) as an animal model for ADHD: a short overview.

Diverse studies indicate that attention-deficit hyperactivity disorder (ADHD) is associated with alterations in encoding processes, including working or short-term memory. Some ADHD dysfunctional domains are reflected in the spontaneously hypertensive rat (SHR). Because ADHD, drugs and animal models are eliciting a growing interest, hence the aim of this work is to present a brief overview with a focus on the SHR as an animal model for ADHD and memory deficits. Thus, this paper reviews the concept of SHR as a model system for ADHD, comparing SHR, Wistar-Kyoto and Sprague-Dawley rats with a focus on the hypertension level and working, short-term memory and attention in different behavioral tasks, such as open field, five choice serial reaction time, water maze, passive avoidance, and autoshaping. In addition, drug treatments (d-amphetamine and methylphenidate) are evaluated.

Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: Structural and functional analysis.

Dopamine plays an important role in fear and anxiety modulating a cortical brake that the medial prefrontal cortex exerts on the anxiogenic output of the amygdala and have an important influence on the trafficking of impulses between the basolateral (BLA) and central nuclei (CeA) of amygdala. Dopamine afferents from the ventral tegmental area innervate preferentially the rostrolateral main and paracapsular intercalated islands as well as the lateral central nucleus of amygdala activating non-overlapping populations of D1- and D2-dopamine receptors located in these structures. Behaviorally, the intra-amygdaloid infusion of D1 agonists and antagonists elicits anxiogenic and anxiolytic effects respectively on conditioned and non-conditioned models of fear/anxiety suggesting an anxiogenic role for D1 receptors in amygdala. The analysis of the effects of D2 agonists and antagonists suggest that depending of the nature of the threat the animal experiences in anxiety models either anxiogenic or anxiolytic effects are elicited. It is suggested that D1- and D2-dopamine receptors in the amygdala may have a differential role in the modulation of anxiety. The possibility is discussed that D1 receptors participate in danger recognition facilitating conditioned-unconditioned associations by the retrieval of the affective properties of the unconditioned stimuli, and in the control of impulse trafficking from cortical and BLA regions to BLA and CeA nuclei respectively whereas D2 receptors have a role in setting up adaptive responses to cope with aversive environmental stimuli.

Role of the amygdaloid cholecystokinin (CCK)/gastrin-2 receptors and terminal networks in the modulation of anxiety in the rat. Effects of CCK-4 and CCK-8S on anxiety-like behaviour and [3H]GABA release.

The amygdala plays a key role in fear and anxiety. The intercalated islands are clusters of glutamate-responsive GABAergic neurons rich in cholecystokinin (CCK)-2 receptors which control the trafficking of nerve impulses from the cerebral cortex to the central nucleus of amygdala. In this study, the nature of the CCK-glutamate-GABA interactions within the rat rostral amygdala, and their relevance for anxiety, were studied. CCK/gastrin-like immunoreactive nerve terminals were found to be mainly restricted to the paracapsular intercalated islands and the rostrolateral part of the main intercalated island. Behaviourally, the bilateral microinjection of CCK-4 (0.043-4.3 pmol/side) or CCK-8S (4.3 pmol/side) into the rostrolateral amygdala reduced the open-arm exploration in the elevated plus-maze without affecting locomotion. In contrast, neither CCK-4 nor CCK-8S (0.043-4.3 pmol/side) had any effects in the shock-probe burying test as compared with their saline-treated controls. Biochemically, CCK-4 (0.3 and 1.5 microm), unlike CCK-8S, enhanced significantly the K(+)-stimulated release of [(3)H]GABA from amygdala slices. These effects were fully prevented by prior superfusion of the slices with either the selective CCK-2 receptor antagonist CR2945 (3 microm), or 6,7-dinitroquinoxaline-2,3(1H,4H)-dione (DNQX), 10 microm, a glutamatergic (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist. It is suggested that CCK modulates glutamate-GABA mechanisms by acting on CCK-2 receptors via volume transmission occurring at the level of the basolateral amygdaloid nucleus and/or by synaptic or perisynaptic volume transmission in the region of the rostrolateral main and paracapsular intercalated islands, resulting in subsequent disinhibition of the central amygdaloid nucleus and anxiety or panic-like behaviour.