ABSTRACT
Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC=pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu(PTSC*)(ONO2)}2] derivative (2, HPTSC*=pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with those shown by the free HPTSC and HPTSC* ligands.
Subject(s)
Colorectal Neoplasms/pathology , Copper/chemistry , Glutathione/chemistry , Thiosemicarbazones/chemistry , Thiosemicarbazones/pharmacology , Cell Line, Tumor , Colorectal Neoplasms/genetics , Crystallography, X-Ray , Cytochromes c/metabolism , Drug Screening Assays, Antitumor , Glutathione/metabolism , Humans , Molecular Structure , Myoglobin/metabolism , Spectrometry, Mass, Electrospray Ionization , Spectroscopy, Fourier Transform InfraredABSTRACT
Although the [CB(11)H(12)](-) carborane does not exhibit an absorption band in UV, its triplet excited state can be generated upon 308 nm laser excitation; also unexpectedly carborane acts as electron donor forming a charge transfer complex with methylviologen that upon illumination gives rise to viologen radical cation.
ABSTRACT
A sample of novel delaminated zeolite ITQ-2 containing Ru(bpy)3(2+) on the external cups and MV2+ included in the independent and not connected channels has been prepared; emission and time-resolved laser flash photolysis has shown unambigously that photoinduced electron transfer from Ru(bpy)3(2+) to MV2+ occurs through the zeolite framework.
ABSTRACT
Pyrene as a fluorophore has been covalently anchored on a delaminated ITQ-2 zeolite having a large external surface area (730 m2 g-1) and the resulting solid found to have a selective response as a heterogeneous sensor for I- in the presence of other halides.
