1.
Bioorg Med Chem Lett
; 11(8): 1081-3, 2001 Apr 23.
Article
in English
| MEDLINE
| ID: mdl-11327595
ABSTRACT
The synthesis of a novel series of guanine analogues is reported. The compounds have been assessed in vitro and some analogues have been found to be inhibitors of phosphodiesterase type 7 (PDE7).
Subject(s)
3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors , Enzyme Inhibitors/chemical synthesis , Enzyme Inhibitors/pharmacology , Guanine/chemical synthesis , Guanine/pharmacology , Isoenzymes/antagonists & inhibitors , Cyclic Nucleotide Phosphodiesterases, Type 3 , Cyclic Nucleotide Phosphodiesterases, Type 4 , Cyclic Nucleotide Phosphodiesterases, Type 7 , Enzyme Inhibitors/metabolism , Guanine/analogs & derivatives , Inhibitory Concentration 50 , Structure-Activity Relationship
2.
Bioorg Med Chem Lett
; 10(18): 2137-40, 2000 Sep 18.
Article
in English
| MEDLINE
| ID: mdl-10999488
ABSTRACT
The synthesis and pharmacological profile of a novel series of 7-methoxybenzofuran-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).