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FEBS Lett ; 426(2): 279-82, 1998 Apr 17.
Article in English | MEDLINE | ID: mdl-9599024

ABSTRACT

The human TRIP-1 (transforming growth factor-beta (TGBbeta)-receptor interacting protein-1) cDNA encodes a protein able to associate specifically with the type II TGFbeta receptor. It is phosphorylated on serine and threonine by this receptor kinase which makes it a strong candidate as part of the TGFbeta signal transduction pathway. We have isolated the genomic sequence of TRIP-1 and found that the complete coding region is organised into 11 exons ranging from 39 to 397 bp and spanning approximately 9 kb of genomic DNA. The 5' flanking region lacks a TATA box but is GC-rich, suggesting that it is a constitutively expressed gene which is in agreement with its wide pattern of expression. Fluorescence in situ hybridisation mapped the TRIP-1 gene to chromosome 1p34.1 whereas a pseudogene is located on chromosome 7q32.


Subject(s)
Chromosomes, Human, Pair 1 , Proteins/genetics , Chromosomes, Human, Pair 7 , Eukaryotic Initiation Factor-3 , Exons , Genes , Humans , In Situ Hybridization, Fluorescence , Introns , Pseudogenes , Restriction Mapping
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