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Pediatr Nephrol ; 23(2): 333-4, 2008 Feb.
Article in English | MEDLINE | ID: mdl-17899204

ABSTRACT

We report on a case of fetal toxicity due to maternal treatment with olmesartan medoxomil. At 29 weeks' gestation, oligohydramnios was found, although the fetus had normal kidneys on ultrasound evaluation. Withdrawal of olmesartan medoxomil, maternal rehydration, and a single dose of furosemide reversed the renal impairment. After term delivery, the neonate was confirmed to have normal renal function. The case suggested that fetal renal impairment due to olmesartan medoxomil may be reversible.


Subject(s)
Angiotensin II Type 1 Receptor Blockers/adverse effects , Fetal Diseases/chemically induced , Imidazoles/adverse effects , Maternal Exposure/adverse effects , Oligohydramnios/chemically induced , Renal Insufficiency/chemically induced , Tetrazoles/adverse effects , Diuretics/therapeutic use , Female , Fetal Diseases/drug therapy , Fetal Diseases/physiopathology , Furosemide/therapeutic use , Gestational Age , Humans , Infant, Newborn , Male , Oligohydramnios/drug therapy , Oligohydramnios/physiopathology , Olmesartan Medoxomil , Pregnancy , Prenatal Diagnosis , Recovery of Function , Renal Insufficiency/drug therapy , Renal Insufficiency/physiopathology , Treatment Outcome
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