1.
Bull Exp Biol Med
; 135(3): 289-92, 2003 Mar.
Article
in English
| MEDLINE
| ID: mdl-12802404
ABSTRACT
Antitumor effect of cyclophosphamide on LS and P388 tumors is realized via apoptosis and on HA-1 and Krebs-2 tumors resistant to apoptosis via necrosis of tumor cells. Phenobarbital induction of cyclophosphamide-metabolizing enzymes decreases and cimetidine inhibition potentiates the effect of cyclophosphamide on LS and P388 cells and does not modulate the effect on HA-1 and Krebs-2 cells. Presumably, apoptosis and necrosis of tumor cell are induced by different cyclophosphamide metabolites.
Subject(s)
Antineoplastic Agents, Alkylating/metabolism , Apoptosis/physiology , Cyclophosphamide/metabolism , Phenobarbital/metabolism , Animals , Anticonvulsants/metabolism , Antineoplastic Agents, Alkylating/therapeutic use , Cell Line, Tumor , Cimetidine/metabolism , Cyclophosphamide/therapeutic use , Cytochrome P-450 Enzyme System/metabolism , Enzyme Inhibitors/metabolism , Humans , Mice , Mice, Inbred Strains , Neoplasm Transplantation , Neoplasms/drug therapy
2.
Dokl Biol Sci
; 386: 426-9, 2002.
Article
in English
| MEDLINE
| ID: mdl-12474762
