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1.
J Med Life ; 8(4): 548-51, 2015.
Article in English | MEDLINE | ID: mdl-26664488

ABSTRACT

Estrogens role in schizophrenia patients is a subject, which has gained an increased attention from the medical community. Estrogens have been shown to inhibit dopamine actions, improve neuronal regeneration, and overall, have a protective role in the pathology of schizophrenia. The adjunctive estrogen therapy for men is currently under debate. Antipsychotic medication is known to influence the hypothalamo-hypophyseal - gonadal axis by inducing variable degrees of hyperprolactinemia. Several studies have found that some of the atypical antipsychotics lower cortisol levels in patients and also in healthy controls. We have investigated the effects of clozapine and risperidone on estradiol levels in men with schizophrenia. We have also evaluated the levels of prolactin and cortisol, taking into account the possible influence of antipsychotic drugs on both these hormones. Both prolactin and cortisol also have the potential to regulate sexual hormones biosynthesis. Our study found decreased estradiol levels in men with schizophrenia treated with clozapine and risperidone, while prolactin levels were increased only in the risperidone treated group. Cortisol levels are not statistically significant different between groups.


Subject(s)
Clozapine/therapeutic use , Estradiol/blood , Hydrocortisone/blood , Risperidone/therapeutic use , Schizophrenia/blood , Schizophrenia/drug therapy , Adult , Antipsychotic Agents/therapeutic use , Benzodiazepines , Case-Control Studies , Humans , Hyperprolactinemia , Male , Middle Aged , Prolactin , Young Adult
2.
J Med Life ; 8 Spec Issue: 43-6, 2015.
Article in English | MEDLINE | ID: mdl-26361510

ABSTRACT

Alopecia areata (AA) is an inflammatory and autoimmune disease presenting with non-scarring hair loss. The aethiopathogenesis of alopecia areata is unclear and many factors including autoimmunity, genetic predisposition, emotional and environmental stress are thought to play important roles in its development. Antioxidant/ oxidant balance perturbation is a common feature in autoimmune, emotional and environmental stress. Therefore, our paper discusses the implications of oxidative stress in alopecia areata.


Subject(s)
Alopecia Areata/pathology , Oxidative Stress , Antioxidants/metabolism , Enzymes/metabolism , Humans , Lipid Peroxidation , Reactive Oxygen Species/metabolism
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