ABSTRACT
A study was made of the state of microcirculation and oxygen balance of tissues in 51 patients with chronic adrenocortical insufficiency with various degrees of severity of disease during decompensation and compensation. Methods of biomicroscopy of the eye conjunctival vessels using a photoslit tube and polarography on the LP-7 apparatus were employed. Considerable disorders of microcirculation and tissue oxygen balance in patients with Addison's disease depending on a degree of severity of disease indicated a great role of the adrenocortical hormones in maintaining homeostatic stability and body vital activity.
Subject(s)
Addison Disease/physiopathology , Microcirculation/physiopathology , Oxygen Consumption , Adult , Capillary Permeability , Chronic Disease , Conjunctiva/blood supply , Female , Humans , Male , Middle AgedSubject(s)
Addison Disease/physiopathology , Hemodynamics , Adult , Female , Humans , Male , Middle AgedSubject(s)
Addison Disease/physiopathology , Myocardial Contraction , Adult , Female , Heart Ventricles , Humans , Male , Middle AgedABSTRACT
A study was made of CVS function in 48 patients with Addison's disease by submaximum bicycle ergometry to specify and improve the existing criteria of assessment of a degree of gravity of disease and the working capacity of patients before and after hormonal substitution therapy. According to the results of bicycle ergometry, the working capacity of these patients was lowered, the total volume of work done, loading power, and maximum oxygen consumption were also lowered. The data obtained can be used for assessment of therapeutic efficacy and in medical labor examination to determine the working capacity of patients with hypocorticism.
