Influence of the presence of dental implants on the accuracy and difficulty level of diagnosis of furcation involvement in molars: An in vitro CBCT study.

OBJECTIVE: The aim of this study was to investigate the possible interference of image artifacts (IA) generated by dental implants in the evaluation of furcation involvement (FI) in molars. METHODS: Tomographic scans of first molars (1M) were performed in dry skulls in the absence and presence of titanium (TI) and zirconia (ZI) dental implants. FI grades were simulated in the alveoli of the 1Ms. Diagnostic accuracy of FI and level of difficulty were verified. Chi-squared test and logistic regression analysis were used. RESULTS: There was no difference in the diagnostic accuracy of FI between the arches (p = .117). The highest diagnostic accuracy value for the implant variable was found in the absence of implants (88.3%) and the lowest in the presence of two ZI implants (66.7%). The highest diagnostic accuracy value for FI was observed in grade 0 (G0). There was no significant difference between the arches regarding the evaluators' perception of difficulty (p > .05). Assessments were considered difficult in 12.7% of the TI implants and in 29% of the ZI implants. Regarding the number of dental implants, assessments were considered difficult in 24.4% cases including one implant and 17.4% cases including two implants. The logistic regression model showed a significant p-value only for one and two ZI implants (p = .0061 and p = .0096, respectively). CONCLUSION: The presence of dental implants in the region adjacent to the area of investigation of FI decreased the diagnostic accuracy while increasing the perception of difficulty by the examiners, especially in cases with ZI implants.

The environmental, economic and social sustainability in dental clinics and offices: a systematic review / A sustentabilidade ambiental, econômica e social nas clínicas e consultórios odontológicos: uma revisão sistemática

Not only in Brazil, but there is a worldwide movement in search of environmental sustainability, due to the scarcity of natural resources. Therefore, this research asks: Is environmental, economic and social sustainability inserted in dental clinics and offices? In order to answer the guiding question of this study, a systematic review of the literature was carried out following the methodological guidelines outlined by PRISMA. The search for the articles occurred in the PubMed, Web of Science and Scopus databases. In this research, gray literature was added. The search strategy developed in the databases identified a total of 749 articles. Of these, 647 articles were excluded for not including dental clinics or offices as the object of study, but other areas of Health; in addition, 32 were excluded because they were duplicated. The resulting 70 articles were submitted to full text analysis; of the 53 studies, 28 were included in this research and 25 were excluded. According to the researched literature, there is growing interest and effort among dental professionals in search of sustainability in dental clinics. Although, often, the lack of knowledge and information is not the problem, but putting such knowledge into practice.

Não apenas no Brasil, mas há um movimento mundial em busca de uma sustentabilidade ambiental, devido à escassez de recursos naturais. Portanto, esta pesquisa questiona: A sustentabilidade ambiental, econômica e social está inserida nas clínicas e consultórios odontológicos? A fim de responder à questão norteadora deste estudo, foi realizada uma revisão sistemática na literatura seguindo as diretrizes metodológicas delineadas pelo PRISMA. A busca pelos artigos ocorridos nas bases de dados PubMed, Web of Science e Scopus. Nesta pesquisa, foi criado, ainda, a literatura cinza. A estratégia de busca desenvolvida nas bases de dados identificou um total de 749 artigos.Desses, 647 artigos foram excluídos por não incluir clínicas ou consultórios odontológicos como objeto de estudo, e sim outras áreas da Saúde; além disso, 32 foram excluídos por estarem duplicados. Os 70 artigos fundidos foram elaborados à análise de texto completo; dos 53 estudos, 28 foram incluídos nesta pesquisa e 25 foram excluídos. De acordo com a literatura pesquisada, há interesse e esforço crescente entre os profissionais da Odontologia em busca de sustentabilidade nas clínicas odontológicas. Embora, muitas vezes, a falta de conhecimento e de informação não seja o problema, e sim pôr em tal conhecimento prática.

Overexpression of ALDH1 and EMT marker profile are linked with unfavorable outcome in head and neck cancer

BACKGROUND: The aim of this research was to assess the expression of aldehyde dehydrogenase 1 (ALDH1) and epithelial-mesenchymal transition (EMT) markers in head and neck squamous cell carcinoma (HNSCC), and to correlate them with the clinical and histopathological parameters of a patient cohort with follow-up over an 8-year period. MATERIAL AND METHODS: For this, seventeen HNSCC and non-neoplastic adjacent epithelium (AE) samples were subjected to laser microdissection and real-time PCR to evaluate the mRNA expression of ALDH1, E-cadherin (E-CAD), N-cadherin (N-CAD), and vimentin (VIM). Also, immunohistochemistry was performed for ALDH1, E-CAD, N-CAD, and VIM in the tumor center (TC), invasion front (IF), and AE of the seventeen samples. Mann-Whitney, Kruskal-Wallis and Chi-square tests were used to correlate the mRNA and immunohistochemical ex-pression with different variables, considering p < 0.05. Kaplan-Meier curves were produced for local recurrence, regional metastasis and treatment. RESULTS: A mRNA overexpression of ALDH1 in primary tumors was associated with regional metastasis and a high ALDH1 immunostaining was related to metastasis and a worse patient outcome. Additionally, a favorable outcome was associated with the transition phase and an unfavorable outcome was associated with EMT event. An overall 26.9 months was observed with longer survival associated with surgery and radiotherapy. CONCLUSIONS: However, due to the intense variability inherent to the indicator proteins in the EMT process, the complete profile markers related to this biological process should be continuous investigated

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Validation study of a new method for sexual prediction based on CBCT analysis of maxillary sinus and mandibular canal.

OBJECTIVE: The aim of this study was to evaluate the accuracy of two craniometric methods for sexual prediction (SP) using cone-beam computed tomography (CBCT) in the Dutch population and to construct a formula for each method and then the two combined. DESIGN: One-hundred sixty CBCT images were selected from a Dutch database (80 males and 80 females). The images were analyzed by two examiners taking seven measurements in the maxillary sinus (MS) region (first method) and nine in the mandibular canal (MC) region (second method). The most predictive measurements in both methods were used to develop an equation to determine the accuracy of each method. RESULTS: All measurements showed statistical difference between genders. Logistic regression results showed two variables with greater SP index with 75% accuracy in the first method and four variables with 71.9% accuracy in the second. The two methods combined showed another four variables with 78.5% accuracy. CONCLUSION: All measurements showed statistically significant differences between sexes. The SP accuracy values were 75% for first 71.9% for the second method. When the two methods were combined, the accuracy increased to 78.5%. The formulas developed in this study can be applied as a complementary method for human identification in the Dutch population.

Comparison of accuracy between dental and skeletal age in the estimation of chronological age of Down syndrome individuals.

This study aimed to evaluate the accuracy of dental age (DA) and skeletal age (SA) methods in order to estimate chronological age (CA) in individuals with Down syndrome (DS), contributing to the Forensic Dentistry and making the identification of these individuals age possible. For this, 278 images of individuals were selected and divided in 2 groups: 216 non-DS patients and 62 with DS. At first, DA was evaluated by Nolla method, on panoramic radiographs, followed by SA, evaluated by Greulich and Pyle method. The linear correlation coefficient of Pearson was used for the analysis of concordance between the methods. Paired t-test with confidence interval was used to evaluate the accuracy and Bland and Altman method was applied to estimate limits of concordance. Complementary to this first analysis, descriptive statistics and ANOVA test were applied for comparison among chronological age (CA), dental age (DA) and skeletal age (SA), with a significance level of 95% (p≥0.05), ordering to observe the differences among them. DA, estimated by Nolla, is underestimated in both, DS and non-DS individuals, and it is more notable in DS individuals. SA estimated by Greulich and Pyle method is overestimated, except for non-DS males. The range of variance is greater in SA and DS than DA and non-DS individuals, respectively. A greater accordance was found for DA×CA if compared to SA×CA, indicating that DA, estimated by Nolla method, is more accurate than SA, evaluated by Greulich and Pyle method, for estimating CA of both, DS and non-DS individuals. However, neither method seems to be precise and more caution is required for age estimation in DS individuals.

A Wormian Bone, Mimicking an Entry Gunshot Wound of the Skull, in an Anthropological Specimen.

Wormian bones (WB) are irregular small cranial ossicles found along suture lines and fontanels. In Brazil, gunshot wounds to the skull are quite common in young individuals. Nevertheless, as far as we know, this is the first report of a WB giving an erroneous aspect of gunshot entrance due to its displacement position. The present manuscript describes the case of a Brazilian young man who died due to ballistic trauma, where a gaping bony defect on the right side of the skull was thought to be the exit wound of an injury related to the destruction found on the left side, highly suggestive of firearm injury. Thus, this case study has brought to light similarities between a traumatic lesion and an orifice of a WB, with emphasis on differential diagnosis during routine anthropological examinations.

Keratocystic odontogenic tumor: role of cone beam computed tomography and magnetic resonance imaging.

Keratocystic odontogenic tumors (KCOTs) are known for unique and varied behavior, high recurrence rates, and distinctive histopathologic findings. Differential diagnosis and management of KCOTs may be challenging because other jaw lesions may present similar characteristics. Careful interpretation of cone beam computed tomograms and magnetic resonance images has great significance for precise assessment of KCOTs and their relationships to adjacent anatomic structures as well as for treatment planning. This case report describes a KCOT that developed in the left angle and mandibular ramus in association with a semierupted third molar.

Mandibular sexual dimorphism analysis in CBCT scans.

The aim of this study was to evaluate sexual dimorphism using anthropometric measurements on mandibular images obtained by cone beam computed tomography (CBCT). The sample consisted of 160 CT scans collected from a Brazilian population (74 males, 86 females) aged 18-60 years. The CBCT images were analyzed by five reviewers. Six measurements (ramus length, gonion-gnathion length, minimum ramus breadth, gonial angle, bicondylar breadth, and bigonial breadth) were collected for the sexual prediction analysis. For the statistical analysis, intraclass correlation was used to evaluate intra- and inter-reviewers, analysis of variance was used to compare the mean values of these measurements, binary logistic regression equations were created to predict sex. Using these four variables, the rate of correct sex classification was 95.1%. After, the discriminant function was used to validate the formula built. Accuracy of 93.33% and 94.74% was found for estimating male and females, respectively. Thus, the formula developed in this study can be used for sex estimation in forensic settings.

Anatomic characterization of mental foramen through cone beam computed tomography at dentate and edentulous areas / Caracterização anatômica do forame mentual em áreas dentadas e edêntulas por meio de Tomografia Computadorizada de Feixe Cônico (TCFC)

Objetivo: Caracterizar e comparar as posições e dimensões de abertura dos Forames Mentuais (FM) entre áreas edêntulas e dentadas em imagens por tomografia computadorizada de feixe cônico (TCFC). Material e Métodos: Analisou-se 72 exames de TCFC, abrangendo toda a mandíbula, obtidos em tomógrafo da marca i-CAT Next Generation (imaging Sciences International, Hatfield, PA, EUA). Estes foram divididas em 02 grupos: Grupo D (dentados) apresentando o 1º e 2º pré-molares inferiores correspondentes e Grupo E (edêntulos) sem ambos os pré-molares inferiores correspondentes. Foram realizadas, nos cortes transversais, 02 medidas em cada região: altura FM – correspondente à distância vertical entre o ponto mais inferior do canal mentual à cortical externa da base da mandíbula (AlFM) e abertura FM - correspondente à maior distância vertical entre as corticais externas superior e inferior do FM (AbFM). Adicionalmente, no Grupo D, foi estudada a posição do FM em relação a 04 referenciais: 1º pré-molar, entre 1º e 2º pré-molares, 2º pré-molar e outras localizações. Foi realizado o Teste t para amostras independentes e a análise descritiva. Resultados: Os resultados evidenciaram que houve diferença, estatisticamente significante, apenas na AbFM, entre os dois grupos, com tendência a um aumento desta no grupo D. No Grupo E, a houve diferença estatisticamente significante entre os sexos em relação à AbFM, com tendência a um maior valor para o sexo masculino. No grupo D, a localização do FM de maior frequência foi na região de 2o pré- molares (65,9%) e a de menor frequência na região de 1o pré-molares (4,9%). Conclusão: o edentulismo influenciou, apenas a dimensão da abertura do FM, com redução da mesma, pacientes edêntulos do gênero masculino, tendem a ter um valor maior de abertura de forame que pacientes edêntulos femininos.

Objective: To characterize and compare the positions and dimensions of the mental foramen (MF) openings between dentate and edentulous areas on cone beam computed tomography (CBCT) images. Material and Methods: Seventy-two CBCT images (i-CAT Next Generation, Imaging Sciences International, Hatfield, PA, USA) of the mandible were analyzed. The CBCT images were divided into two groups: Group D (dentate) - with first and second mandibular premolars; Group E (edentulous) - without first and second mandibular premolars. At the transversal cuts, two measurements were obtained: MF height – the vertical distance between the lowest point of the mandibular canal to the external cortical of the mandible’s base (MFH); MF opening – the greatest vertical distance between the superior and inferior MF external corticals (AbMF). Also, in Group D, the MF position was studied in relation to four landmarks: 1st premolar, between 1st and 2nd premolar; 2nd premolar; and other locations. Independent sample t-test and descriptive analysis were applied. Results: Only the distance AbMF showed statistically significant difference between groups, with tendency towards increasing in group D. Group E exhibited statistically significant difference between genders for the distance AbMF, with tendency towards greater values for males. Group D showed that MF was more frequently located at the area of the 2nd premolars (65.9%), while the area of the 1st premolars was that of smallest frequency (4.9%). Conclusion: the edentulism only reduced the dimension of MF opening. Edentulous males had a greater MF opening than edentulous females

Squamous Odontogenic Tumor: Literature Review Focusing on the Radiographic Features and Differential Diagnosis.

Since its first publication in 1975, the squamous odontogenic tumor remains the rarest odontogenic lesion, with around 50 cases in the English-language literature in which the microscopic characteristics are frequently very well demonstrated. However, articles which discuss the radiographic aspects are scarce, especially with emphasis on the differential diagnosis. The present treatise proposes an assessment of jaw lesions with the same radiographic characteristics of the squamous odontogenic tumor to clarify the main findings for dental clinicians during routine diagnosis.

Lateral pterygoid muscle volume and migraine in patients with temporomandibular disorders.

PURPOSE: Lateral pterygoid muscle (LPM) plays an important role in jaw movement and has been implicated in Temporomandibular disorders (TMDs). Migraine has been described as a common symptom in patients with TMDs and may be related to muscle hyperactivity. This study aimed to compare LPM volume in individuals with and without migraine, using segmentation of the LPM in magnetic resonance (MR) imaging of the TMJ. MATERIALS AND METHODS: Twenty patients with migraine and 20 volunteers without migraine underwent a clinical examination of the TMJ, according to the Research Diagnostic Criteria for TMDs. MR imaging was performed and the LPM was segmented using the ITK-SNAP 1.4.1 software, which calculates the volume of each segmented structure in voxels per cubic millimeter. The chi-squared test and the Fisher's exact test were used to relate the TMD variables obtained from the MR images and clinical examinations to the presence of migraine. Logistic binary regression was used to determine the importance of each factor for predicting the presence of a migraine headache. RESULTS: Patients with TMDs and migraine tended to have hypertrophy of the LPM (58.7%). In addition, abnormal mandibular movements (61.2%) and disc displacement (70.0%) were found to be the most common signs in patients with TMDs and migraine. CONCLUSION: In patients with TMDs and simultaneous migraine, the LPM tends to be hypertrophic. LPM segmentation on MR imaging may be an alternative method to study this muscle in such patients because the hypertrophic LPM is not always palpable.

Cone-beam computed tomography analysis of prevalence of nasal septum deviation and its relationship with the presence of middle concha bullosa / Avaliação da prevalência e relação entre o desvio de septo nasal e a presença de concha média bolhosa por meio de tomografia computadorizada de feixe cônico

Objetivo: Este estudo teve com objetivo analisar a prevalência do desvio do septo nasal e da presença de concha nasal média bolhosa e estudar a possível relação entre estes por meio de imagens por tomografia computadorizada de feixes cônicos (TCFC). Material e Métodos: Foram selecionados 118 exames de TCFC de arquivo, previamente adquiridos por indicações diversas para odontologia. Todos os exames foram realizados em tomógrafo i-CAT Next Generation (imaging Sciences International, Hatfield, PA, EUA) com o mesmo protocolo, tendo o FOV (Field of View) abrangendo o terço médio e inferior da face. Todas as imagens foram avaliadas no software especifico do sistema por 01 avaliador devidamente treinado. O desvio de septo nasal, a concha nasal média bolhosa e demais dados foram tabulados e realizada a análise descritiva dos mesmos. O teste de McNemar foi aplicado para se estudar a possível relação entre os mesmos. Resultados: Os resultados indicaram que, nos casos em que não ocorria o desvio de septo nasal, 73,5% destes não apresentaram e 26,5% destes apresentaram a concha média bolhosa. Considerando-se apenas os casos que apresentaram o desvio de septo nasal para um dos lados, a proporção que não apresentou a concha média bolhosa para o mesmo lado foi de 77,1% e a que apresentou também a concha média bolhosa para o mesmo lado foi de 22,9%. Conclusão: Concluiu-se que não houve relação (p = 0,568) entre a presença das duas variáveis analisadas na pesquisa – desvio de septo nasal e presença de concha média bolhosa.

Objective: This study aimed to analyze the prevalence of nasal septum deviation and the presence of middle nasal concha bullosa, as well as to study the possible relationship between these findings by means of cone-beam computed tomography (CBCT) images. Material and Methods: One hundred and eighteen CBCT exams were selected from a file previously acquired for diverse reasons in dentistry. All images were obtained with CT i-CAT Next Generation (Imaging Sciences International, Hatfield, PA, USA) with the same protocol, and the field of view (FOV) covered the middle and lower third of the face. All images were evaluated in the specific software system by one trained evaluator. The deviated septum, nasal concha bullosa, and other data were tabulated and a descriptive analysis was performed. The McNemar test was used to study the possible relationship between them. Results: The results indicated that, in cases without nasal septum deviation, 26.5% and 73.5% were associated or not to the presence of middle concha bullosa, respectively. Considering patients with nasal septum deviation on one side only, the proportions of 22.9% and 77.1% were associated or not to middle concha bullosa in the same direction, respectively. Conclusion: Thus, it was concluded there was no relationship (p = 0.568) between nasal septum deviation and the presence of middle concha bullosa.

Influência de terceiros molares não erupcionados em fratura de ângulo e côndilo / Influence of unerupted third molars on angle and condyle fracture

Condylar and angle fractures are the most common types of mandibular injuries. There is evidence in the literature suggesting that the presence of unerupted lower third molars increases the risk of angle fracture and reduces the chance of condyle fracture. The present paper reports on a case of a 19-year-old Caucasian man who had bilateral angle fracture associated with the two lower unerupted third molars. No other fracture was detected on the panoramic radiograph. This case suggests that unerupted lower third molars increase the risk of angle fracture whereas preventing condyle fracture. Reduction of the bone mass of the angle in the presence of third molars and disruption of the oblique ridge with partially erupted molars support our findings. As the treatment of condyle fracture is more complex, it might not be appropriate to strengthen the mandibular angle, making the mandible more vulnerable to condylar fractures by means of prophylactic extraction of asymptomatic unerupted third molars.

Côndilo e ângulo são os locais onde as fraturas mandibulares ocorrem com maior frequência. Há evidências na literatura sobre a propensão para fratura de ângulo mandibular na presença de terceiros molares inferiores não-erupcionados, bem como redução da respectiva probabilidade de fratura em côndilo. O caso relatado envolve um homem branco, de 19 anos de idade, que teve fratura bilateral do ângulo em associação com os dois terceiros molares inferiores não-erupcionados. Nenhuma outra fratura foi detectada na radiografia panorâmica. Os achados deste caso ilustram a evidência de que terceiros molares inferiores não irrompidos aumentam o risco de fratura de ângulo, reduzindo, porém, o risco de fratura em côndilo. Algumas teorias sobre essa associação envolvem a redução da massa óssea do ângulo na presença do terceiro molar, além da ruptura da linha oblíqua quando eles estão parcialmente erupcionados. Como a fratura do côndilo tem um tratamento mais complexo, a exodontia profilática de terceiros molares não-erupcionados assintomáticos pode não ser apropriada, por fortalecer o ângulo mandibular e tornar a mandíbula mais vulnerável às fraturas condilares.