SAFETY AND EFFICACY OF THYMIC PEPTIDES IN THE TREATMENT OF HOSPITALIZED COVID-19 PATIENTS IN HONDURAS.

Coronavirus disease 2019 (Covid-19) active cases continue to demand the development of safe and effective treatments. This is the first clinical trial to evaluate the safety and efficacy of oral thymic peptides. ; We conducted a nonrandomized phase 2 trial with a historic control group to evaluate the safety and efficacy of a daily 250-mg oral dose of thymic peptides in the treatment of hospitalized Covid-19 patients. Comparisons based on standard care from registry data were performed after propensity score matching. The primary outcomes were survival, time to recovery, and number of participants with treatment-related adverse events or side effects by day 20. ; A total of 44 patients were analyzed in this study: 22 in the thymic peptide group and 22 in the standard care group. There were no deaths in the intervention group compared to 24% mortality in standard care by day 20 (log-rank P=0.02). Kaplan-Meier analysis showed a significantly shorter time to recovery by day 20 in the thymic peptide group than in the standard care group (median, 6 days vs. 12 days; hazard ratio for recovery, 2.75 [95% confidence interval, 1.34 to 5.62]; log-rank P=0.002). No side effects or adverse events were reported. ; In patients hospitalized with Covid-19, the use of thymic peptides resulted in no side effects, adverse events, or deaths by day 20. Compared with the registry data, a significantly shorter time to recovery and mortality reduction were measured.

[Non-invasive dynamic studies of the cervico-thoraco-brachial pathway. Anatomo-clinical correlative study]. / Explorations dynamiques non invasives de la traversée cervico-thoraco-brachiale. Etude corrélative anatomo-clinique.

Based on a computer assisted analysis of the anatomic and biomechanic features of 200 subjects, the authors propose a dynamic approach to the exploration of the cervico-thoraco-brachial pathway. Results are given for 70 healthy and diseased subjects. Ultrasonic evaluations of the arterial component, dynamic echography of the axillo-subclavian venous component, electrophysiology including conventional electromyography, somesthesic and motor evoked potentials, and advanced imagery provide a panel of complementary diagnostic techniques.

From classical to modern anatomy or computer-assisted biomechanics.

The authors describe their methodology - dissection, photography, informational - permitting a biomechanical approach together with the study of the changes in the topographic anatomy of a region during movement.

[Systematization of the musculo-tendinous architecture of the human biceps (musculus biceps brachii)]. / Systématisation de l'architecture musculo-tendineuse du biceps humain (musculus biceps brachii).

The structure of the brachial biceps is studied based upon the bilateral dissections of six subjects. The object of this work consists of determining the distribution of the group and muscular fibers in relation to the two proximal insertions and the two distal insertions. It is possible to describe the subgroups within each structure. The objective of each of these subgroups is considered within the framework of the coordination between the two muscular formation and the double insertions on the structure of the forearm. It is probable that this muscular formation corresponds to two different movements of the forearm during the locomotory progression. This work can be utilised in the sphere of the comparative biomechanical observation. Also electromyographic and the histochemical characteristics of the muscular group.

Correlative anatomic and CT study of the lumbar lateral recess.

The lumbosacral nerve roots and their relation to the lateral recess in the lumbar region were studied by computed tomography both in anatomic specimens from six cadavers and in vivo in 100 patients with or without disk herniation. The anatomic and tomodensitometric correlations are discussed. The normal morphology and contents of the lumbar spinal canal can be used as a guide to radiologic diagnostic exploration, which in turn can indicate the etiology and extent of lumbar sciatica and the course of treatment.

Normal CT anatomy of the spine. Anatomo-radiological correlations.

To analyse the anatomo-radiological correlation of the spine and spinal cord, 22 formalized, frozen anatomical specimens corresponding to different regions of the spinal column (8 cervical, 5 dorsal, and 9 lumbar) were studied by CT scans on axial, sagittal and coronal planes and by contact radiography after they were cut into anatomical slices in order to clarify the normal CT anatomy of the spinal column. The results obtained from CT patient scans, performed exclusively on the axial plane, were compared with those obtained from the anatomical specimens (both CT and contrast radiography). High resolution CT programs were used, enabling us to obtain better individualization of the normal structures contained in the spinal column. Direct sagittal and coronal sections were performed on the specimens in order to get further anatomo-radiological information. Enhanced CT studies of the specimens were also available because of the air already present in the subarachnoid spaces. Excellent visualization was obtained of bone structures, soft tissue and the spinal cord. High CT resolution of the spine appears to be an excellent neuroradiological procedure to study the spine and spinal cord. A metrizamide CT scan is, however, necessary when a normal unenhanced CT scan is insufficient for diagnosis and when the spinal cord is not clearly visible, as often happens at the cervical level. Clinical findings are certainly very useful to ascertain the exact CT level and to limit the radiation exposure.

[General anesthesia for ophthalmic surgery in patients over 80 years]. / L'anesthésie générale chez les opérés ophtalmologiques de plus de quatre vingts ans.

Among 150 elderly ophthalmological patients over 80 years old, only seven patients did not undergo a general anaesthesia, because of respiratory insufficiency and/or ventricular extrasystoles. The other, 143 patients underwent 178 operations under general anaesthesia with minimal per and postsurgical complications. Therefore, it seems unjustified to deny the benefit of general anaesthesia to ophthalmologic surgical patients more than 80 years old.