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Effect of optical isomers of (+/-)-fenfluramine on pentobarbitone brain and plasma concentrations and sleeping time.

Marzi, E; Gambazza, K; Piccinelli, G; Garattini, S; Bartosek, I.

J Pharm Pharmacol ; 33(10): 677-9, 1981 Oct.

Article in English | MEDLINE | ID: mdl-6117628

Subject(s)

Fenfluramine/pharmacology , Pentobarbital/metabolism , Animals , Brain/drug effects , Brain/metabolism , Drug Interactions , Male , Pentobarbital/pharmacology , Rats , Sleep/drug effects , Stereoisomerism , Time Factors

Effects of chronic treatment with di-(2-ethylhexyl) phthalate on rat liver microsomal activities.

Zuccato, E; Cantoni, R; Bidoli, F; Rizzardini, M; Salmona, M; Caccia, S; Gambazza, K; Bartosek, I; Guaitani, A; Marcucci, F; Mussini, E.

Toxicol Lett ; 6(1): 51-8, 1980 Jun.

Article in English | MEDLINE | ID: mdl-7423546

ABSTRACT

The effects of chronic di-(2-ethylhexyl)phthalate (DEHP) on liver microsomal activity were studied in rats. Daily doses of 50 and 500 mg/kg for 4 weeks did not affect O-demethylation, aromatic hydroxylation, N-demethylation, C3-hydroxylation, styrene monooxygenase, glutamic-oxalacetic and glutamic-pyruvic transaminases (GOT, GPT). Inhibition of glutathione-S-transferase A and C and induction of epoxide hydrase, glutathione-S-transferase B and nitroreductase activity were instead observed. Protein, cytochrome P-450 and reduced glutathione levels in liver did not appear to be affected by DEHP pretreatment.

Subject(s)

Diethylhexyl Phthalate/pharmacology , Microsomes, Liver/drug effects , Phthalic Acids/pharmacology , Animals , Cytochrome P-450 Enzyme System/metabolism , Glutathione/metabolism , Glutathione Transferase/metabolism , Male , Rats

Subject(s)

ABSTRACT

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