Subject(s)
Pregnancy, Ectopic/diagnosis , Adult , Cervix Uteri , Female , Humans , Hysterectomy , Pregnancy , Pregnancy, Ectopic/pathology , Pregnancy, Ectopic/surgery , Uterus/pathologySubject(s)
Adolescent , Adult , Humans , Female , Congenital Abnormalities , Vagina , Amenorrhea , Klippel-Feil SyndromeSubject(s)
Aging , Blood Pressure , Adolescent , Adult , Diastole , Female , Humans , Male , Mexico , Middle Aged , Sex FactorsABSTRACT
Complex segregation analysis was applied to a sample of 12,293 nuclear families each with at least 1 diabetic patient. The families were divided into two groups depending on the proband's treatment: insulin-dependent (IDG) and insulin-independent (IIG). Heterogeneity analysis has revealed a highly significant difference in the IIG group when families were divided into different mating types. The higher recurrence risk was found in the group with affected mothers. Also evidence for a major recessive gene was found in the IGG group, while it was not possible to distinguish between the hypothesis for absence of a major locus and absence of polygenic inheritance in the IDG group. Risks to develop the disease were calculated for a few typical situations.
