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Dokl Biochem Biophys ; 493(1): 167-170, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32894457

ABSTRACT

The influence of the cellular cholesterol content on the cytotoxicity of endovanilloids acyldopamines was studied in MDA-MB-231 and MCF 10A cells. The activity of acyldopamines depends on the cellular cholesterol content, and a decrease in cholesterol content increases the cytotoxicity of acyldopamines.


Subject(s)
Atorvastatin/pharmacokinetics , Breast Neoplasms/pathology , Cholesterol/metabolism , Dopamine/analogs & derivatives , Anticholesteremic Agents/pharmacology , Apoptosis , Atorvastatin/pharmacology , Breast Neoplasms/drug therapy , Breast Neoplasms/metabolism , Dopamine/pharmacology , Female , Humans , Receptors, Cannabinoid/metabolism , Tumor Cells, Cultured
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