ABSTRACT
Hypoxia triggers hypoxia-inducible factor (HIF). Not only hypoxia triggers downstream HIF target genes for transcription, as intermittent hyperoxia also possesses similar capabilities, suggesting that fluctuations in oxygen availability may be equally important for inducing HIF transcription. This review describes some of the mechanisms, whereby intermittent hyperbaric hyperoxia may explain some of the observations during hyperbaric oxygen therapy such as enhanced wound healing, angiogenesis and tissue healing, and concludes that oxidative stress enhances certain antibiotics in infection control.
Subject(s)
Hyperbaric Oxygenation , Hyperoxia , Decompression , Humans , Hypoxia , OxygenABSTRACT
A 55-year-old woman was hospitalised due to sudden redness and swelling around the left eye as well as malaise. Prior to hospitalisation, the patient was treated with antibiotics because of a dental infection. The patient was admitted to the hospital for more than three weeks and received intravenous antibiotics, which was changed several times due to treatment failure. After three weeks, she had a rooted tooth removed and she was discharged within days. Preseptal cellulitis as a complication to odontogenic infection can develop into a critical and life-threatening condition.
Subject(s)
Cellulitis , Eyelid Diseases , Anti-Bacterial Agents/therapeutic use , Cellulitis/drug therapy , Edema/drug therapy , Eyelid Diseases/drug therapy , Female , Hospitalization , Humans , Middle AgedABSTRACT
BACKGROUND: To present a rare case of a 2-year-old girl with neurofibromatosis type 1 (NF1) who presented with ptosis of the right upper eyelid along with a tumor in the eyelid. METHODS: A magnetic resonance imaging scan of the orbit revealed a solid tumor located extraconally at the site of the right lacrimal gland. A transcranial orbitotomy was performed. RESULTS: Histopathological examination demonstrated expanded nerve branches/fascicles cut in various planes in between normal lacrimal gland acini. These findings were consistent with a plexiform neurofibroma presumably deriving from the lacrimal nerve and/or a supraorbital nerve branch. CONCLUSION: This is the first case of a plexiform neurofibroma involving the lacrimal gland ever described and the tumor shows similarities with neurofibroma in other salivary glands with a high recurrence rate. Plexiform neurofibromas are frequently seen in patients with NF1 and rarely undergo malignant transformation.
