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RSC Adv
; 14(28): 20056-20060, 2024 Jun 18.
Article
in English
| MEDLINE
| ID: mdl-38911828
ABSTRACT
Bifunctional chiral squaramide-catalyzed highly enantioselective Michael addition of nitromethane to diverse 2-enoylazaarenes was successfully performed. This protocol provided a set of chiral azaarene-containing γ-nitroketones with up to 98% yield and 98% ee in a solvent-free catalytic system under mild conditions. Furthermore, gram-scale synthetic utility was also showcased.