[Amyloid-producing leiomyoma of the womb--a complete morphological study and possible etiology].

Case study of a 41 year old woman with tumor-related amyloidosis in a singular intramural leiomyoma of the uterine corpus. The tumor has been thoroughly revised with electron microscopy and underwent a histological, histochemical, and imunohistochemical studies. A hypothesis of its origin has been suggested. To our knowledge, this is the first documented case of amyloid-producing leiomyoma.

[Endometrial hyperplasia and carcinoma in situ]. / Khiperplazii i carcinoma in situ na endometriuma.

Endometrial hyperplasias--both simple and adenomatous are presented, as well as the differences between them and the endometrial carcinoma. The concept of endometrial carcinoma in situ (ESIS) and the criteria for invasiveness by the malignancies of the uterine corpus are discussed. Illustrations for various cases with ESIS are provided and the clinical behaviour by ESIS is discussed.

[Massive ovarian edema--a case report]. / Masiven otok na iaichnik--opisanie na sluchai.

A case with massive ovarian oedema, which is a rare pseudotumorous condition in young women, is described. The conceptions about the etiology and pathogenesis are considered as well as the morphological changes (with the corresponding clinical symptoms) which could be found in the affected ovary. Attention is drawn to the differential diagnostical difficulties and to the possibilities of semiconservative treatment of this rare clinicomorphological entity.

[Primary multiple malignant tumors of the female genitalia]. / Purvichno mnozhestveni zlokachestveni tumori na zhenskite genitalii.

Occurrence of multiple malignant neoplasms in individuals is rather rare but not casuistic phenomenon that should not be neglected in oncologic practice. Our present work demonstrates 11 cases with primary multiple malignant tumors of female genital tract, that have been checked and followed for a two-year period (1993-1995) at the State Obstetric and Gynecology University Hospital. In discussion we argue on criteria that help the differentiation between primary, simultaneously originated multiple neoplasms and metastatic tumors.

[Malignant Müllerian mixed tumors of the female genitalia]. / Maligneni smeseni miulerovi tumori na zhenskite genitali.

Morphological features and clinical data of 27 malignant mixed Müllerian tumors of uterus and ovaries are represented. These neoplastic entities have been systematized and controversial problems of terminology, nature and origin, as well as macroscopic and histopathological features have been discussed. Based on our own experience and on references to literature on this subject, clinicopathological correlation have been analyzed in order to point out reliable criteria for differential diagnosis, prognosis for therapeutic response and biological behavior of these tumors.

[Myxoid myomas of the uterus]. / Miksoidni miomi na matkata.

Two cases of myxoid smooth muscle tumours of the uterus have been reported. Clinical and morphological characteristics are briefly described. Inspite of the lack of cellular and nuclear atypia and mitotic figures below 2 in 10 high power fields, the clinical course was very malignant. A review of the literature on this new entity from the last 10-12 years has been made.

[The morphological findings in the myometrial arteries and in the placenta with reference to the age of primaparae]. / Morfologichni nakhodki v miometrialnite arterii i v platsentata s ogled vuzrastta na purvorazhdashti zheni.

The authors investigate primiparous women at various ages, searching for eventual changes in uterine blood vessels and in the placenta, which eventually could have unfavourable effect on the fetus. The study established progressive thickening due to fibrosis of the muscular layer of the myometrial arteries (in reduction of smooth muscular elements) as well as delay of maturation and differentiation of placental villi with advancement of age of the pregnant woman. These phenomena independently could be the cause for more frequent unfavourable outcome of pregnancy in elderly pregnant women.