ABSTRACT
AIM: The aim of the present study is to assess the relationship between chronological age (CA) and the measurement of the open apices in teeth and also assess the accuracy of Cameriere methods on dental age (DA) estimation in the South Indian population. SUBJECTS AND METHODS: A sample of 200 orthopantomographs of children aged between 10 and 15 years were collected. The seven left permanent mandibular teeth were evaluated with Cameriere method. RESULTS: Regression analysis was carried out which derived the following linear regression formula: Age = 14.117 - 0.01 g - 1.732W3 + 0.016N0 - 0.289 × 5 - 0.099.s. N0. The equation explained 88.3% (R 2 = 0.883) of the total deviance. The accuracy of the European formula and South Indian formula was determined by the difference between the estimated DA and CA. Cameriere formula produced 32% and 18% of absolute residuals falls within the range of ± 1 and ± 0.5 years, whereas the new regression formula produced 72% and 35% within range of ± 1 and ± 0.5 years. CONCLUSION: This further highlight the importance of population-specific formula keeping in mind about variation in dental maturation across different regions.
ABSTRACT
BACKGROUND: Oral cancer is a disease with complex etiology. There is a strong evidence for the role of smoking, alcohol, genetic susceptibility, and indications that DNA viruses could also be involved in oral cancer. Recognized initially as sexually transmitted agent, human papilloma virus (HPV) is now considered a human carcinogen. Papilloma viruses are epitheliotropic viruses. A strong association of cervical cancer has been implicated with high-risk HPV16 and HPV18 infections, establishing the viral pathogenesis of the carcinoma. The etiopathogenesis is still unclear referring mainly to conflicting evidences in the detection of such viruses in oral carcinoma in spite of few studies suggesting their positive correlation. AIM OF THE STUDY: This systematic meta-analysis aimed to provide evidence-based analysis of literature relating oral cancer and HPV, along with identification of reliable diagnostic methodology for identifying HPV in oral and oropharyngeal cancer. MATERIALS AND METHODS: A systematic review was performed using PubMed (from the year 1995 to 2015), Medline, Cochrane, ScienceDirect, and the Internet search. Reviewed literature included randomized control trials, cross sectional and cohort studies. Pooled data were analyzed by calculating relative risk and odds ratios (ORs), using a binary random-effects model. RESULTS: Out of 1497 cases, 588 patients were positive for HPV DNA, detected by various methods. About 39.27% of case samples were positive for HPV DNA. The calculated OR was 2.82 and 95% confidence interval, which showed significantly an increased risk of HPV among case group when compared to that of controls. CONCLUSION: The present meta-analysis suggests a potentially significant casual relation between HPV and oral and oropharyngeal cancers.
