Subject(s)
Bile Acids and Salts/physiology , Animals , Biological Transport , Blood Cells/cytology , Blood Cells/physiology , Brain/cytology , Brain/physiology , Cattle , Cholanes/physiology , Cholic Acids/physiology , Epithelial Cells , Epithelium/physiology , Humans , Intestinal Mucosa/cytology , Intestinal Mucosa/physiology , Intestinal Secretions/physiology , Lipids/physiology , Liver/cytology , Liver/physiology , Male , Muscles/cytology , Muscles/physiology , Neuromuscular Junction/cytology , Neuromuscular Junction/physiology , Neurons/cytology , Neurons/physiology , Proteins/physiology , Rats , Synaptic TransmissionSubject(s)
Amylases/metabolism , Bis-Trimethylammonium Compounds , Intestinal Mucosa/enzymology , Starch/metabolism , Surface-Active Agents/pharmacology , Animals , Cattle , Deoxycholic Acid/pharmacology , Octoxynol , Polyethylene Glycols/pharmacology , Polymers/pharmacology , Polysorbates/pharmacology , Quaternary Ammonium Compounds/pharmacology , Sodium Dodecyl Sulfate/pharmacologySubject(s)
Surface-Active Agents/pharmacology , Urinary Bladder/drug effects , Water/metabolism , Animals , Anura , Bile Acids and Salts/pharmacology , Biological Transport/drug effects , Cell Membrane Permeability/drug effects , Dose-Response Relationship, Drug , Quaternary Ammonium Compounds/pharmacology , Rana esculentaABSTRACT
Solubilization of cholesterol by sodium salts of cholic, glycocholic, deoxycholic, lithocholic and oleic acids was studied. Dynamics of the solubilization process is described and a comparative characteristic of solubilizing ability of the substances under investigation is given. Cholesterole solubilization is studied as dependent on the concentration of the given substances. The possible mechanisms of solubilization is discussed.
Subject(s)
Bile Acids and Salts , Cholesterol , Oleic Acids , Cholic Acids , Deoxycholic Acid , Glycocholic Acid , Lithocholic Acid , Sodium , SolubilitySubject(s)
Erythrocyte Membrane/physiology , Erythrocytes/physiology , Osmotic Fragility , Hemolysis , HumansABSTRACT
Surfactants in low concentrations (1.10(-5) and 1.10(-4) g/ml) altered the action of the antidiuretic hormone on the permeability of the wall of frog urinary bladder. Anionogenic sodium cholate, nonionogenic twin-80 and cationoactive ethonium depressed the action of the antidiuretic hormone. Polyampholite eBM-4 enhanced the effect of the antidiuretic hormone. The effect of saponin depended on the concentration of the preparation. Of interest is a possibility of using the surfactants for influencing the mechanisms regulating water balance in the organism.
Subject(s)
Cell Membrane Permeability/drug effects , Surface-Active Agents/administration & dosage , Urinary Bladder/drug effects , Vasopressins/administration & dosage , Animals , Anura , Cholic Acids/pharmacology , Drug Synergism , Glycocholic Acid/pharmacology , Polysorbates/pharmacology , Quaternary Ammonium Compounds/administration & dosage , Saponins/pharmacology , Vasopressins/antagonists & inhibitorsABSTRACT
Microelectrode method was applied to the study of the influence of sodium bile salts (BS), saponin and between-80 on the end-plate potentials (EPP) of m. sartorius of Rana ridibunda. Bile salts in a concentration of 10(-5) g/ml did not change these potentials significantly. With increase of the BS concentration up to 10(-4) g/ml the amplitude of EPP increased 1.5- 3 times. The action of these substances in a concentration up to 10(-3) g/ml caused similar, but more rapid, increase in the EPP amplitude, and then the amplitude decreased. Saponin and tween-80 were less efffective in their action on EPP, but evoked muscle contraction. It is suggested that an increase in the EPP amplitude as a result of the action of the mentioned agents was chiefly connected with stimulation of the acetylcholine release by the nerve terminals.
